Reactome | Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid

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Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid Show undefined attributes

authored	[InstanceEdit:9699040] Gillespie, Marc E, 2020-09-09
catalystActivity	[CatalystActivity:2159870] serine-type endopeptidase activity of FURIN [plasma membrane] [CatalystActivity:9686728] serine-type endopeptidase activity of TMPRSS2 [plasma membrane]
category	uncertain
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9699008] Gillespie, Marc E, 2020-09-05
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9698988
disease	[Disease:9683912] COVID-19
displayName	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid
edited	[InstanceEdit:9699008] Gillespie, Marc E, 2020-09-05
eventOf	[Pathway:R-HSA-9694614] Attachment and Entry - Homo sapiens
followingEvent	[Reaction:R-HSA-9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell - Homo sapiens [Reaction:R-HSA-9694723] Uncoating of SARS-CoV-2 Genome - Homo sapiens
input	[Complex:R-HSA-9694785] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9681513] A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry [LiteratureReference:9684163] Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system [LiteratureReference:9687530] Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response [LiteratureReference:9699000] The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin [LiteratureReference:9765579] Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis [LiteratureReference:9765590] Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation [LiteratureReference:9698993] A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells [LiteratureReference:9767485] The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms [LiteratureReference:9733457] Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion [LiteratureReference:9770330] Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site [LiteratureReference:9770280] Proteolytic activation of SARS-CoV-2 spike protein [LiteratureReference:9770340] Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid
output	[Complex:R-COV-9694461] encapsidated SARS-CoV-2 genomic RNA (plus strand) [cytosol] [EntityWithAccessionedSequence:R-HSA-9683480] glycosylated-ACE2 [plasma membrane] [DefinedSet:R-HSA-2076618] HSPGs [plasma membrane] [Complex:R-COV-9698997] S1:S2:M lattice:E protein [plasma membrane]
precedingEvent	[Reaction:R-HSA-9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell - Homo sapiens
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9698988
summation	[Summation:9698991] SARS-CoV-2 virions attached to the host cell surface via a c...
updateTrackers	[UpdateTracker:9775019] Update Tracker - [BlackBoxEvent:9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid - v80:[addOutput] [UpdateTracker:9847056] Update Tracker - [BlackBoxEvent:9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid - v82:[addCatalystActivity, addLiteratureReference, modifyText, removeRegulator] [UpdateTracker:9775453] Update Tracker - [BlackBoxEvent:9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid - v79:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775019] Update Tracker - [BlackBoxEvent:9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid - v80:[addOutput] [UpdateTracker:9847056] Update Tracker - [BlackBoxEvent:9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid - v82:[addCatalystActivity, addLiteratureReference, modifyText, removeRegulator] [UpdateTracker:9775453] Update Tracker - [BlackBoxEvent:9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid - v79:[modifyText]
(hasEvent)	[Pathway:R-HSA-9694614] Attachment and Entry
(precedingEvent)	[NegativePrecedingEvent:9763986] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid [Reaction:R-HSA-9694723] Uncoating of SARS-CoV-2 Genome [Reaction:R-HSA-9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell

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