Reactome | TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation

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TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation Show undefined attributes

authored	[InstanceEdit:937084] Shamovsky, V, 2010-08-25
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975188
displayName	TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
edited	[InstanceEdit:1014292] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-975118] TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex - Homo sapiens [Reaction:R-HSA-975106] Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation - Homo sapiens
input	4 × [EntityWithAccessionedSequence:R-HSA-450281] IRF7 [cytosol] [Complex:R-HSA-975148] TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:933491] Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 [LiteratureReference:975069] Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling [LiteratureReference:975472] Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
output	[Complex:R-HSA-975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
precedingEvent	[Reaction:R-HSA-975111] TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975188
summation	[Summation:975120] Upon TLR7/8 or 9 stimulation IRF7, but not IRF3, forms a sig...

Referrals

(hasEvent)	[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-975118] TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex [Reaction:R-HSA-975106] Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation