Reactome | SARS-CoV-2 9b binds TOMM70

Schema > Reaction > Entries

SARS-CoV-2 9b binds TOMM70 Show undefined attributes

authored	[InstanceEdit:9757087] Shamovsky, Veronica, 2021-10-27
category	binding
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9709721] Shamovsky, Veronica, 2020-12-17
crossReference	[DatabaseIdentifier:12020746] Mondo:0100096
dbId	9709663
disease	[Disease:9683912] COVID-19
displayName	SARS-CoV-2 9b binds TOMM70
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
eventOf	[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - Homo sapiens
input	[Complex:R-COV-9709655] 9b homodimer [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-HSA-1252129] TOMM70 [mitochondrial outer membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9709759] SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70 [LiteratureReference:9709690] Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms [LiteratureReference:9754819] Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions [LiteratureReference:9754818] Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90 [LiteratureReference:9825253] Binding of SARS-CoV-2 protein ORF9b to mitochondrial translocase TOM70 prevents its interaction with chaperone HSP90
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-2 9b binds TOMM70
output	[Complex:R-HSA-9709659] TOMM70:9b [mitochondrial outer membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9727300] 9b homodimer localizes to the mitochondrial outer membrane - Homo sapiens
regulatedBy	[NegativeRegulation:9758498] Negative regulation by 'p-S53-9b [cytosol]'
regulationReference	[RegulationReference:9758497] Negative regulation by 'p-S53-9b [cytosol]' Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9709663
summation	[Summation:9754546] The severe acute respiratory syndrome coronavirus type 2 (SA...
updateTrackers	[UpdateTracker:9846764] Update Tracker - [Reaction:9709663] SARS-CoV-2 9b binds TOMM70 - v84:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9846764] Update Tracker - [Reaction:9709663] SARS-CoV-2 9b binds TOMM70 - v84:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses