Reactome | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

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TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Show undefined attributes

authored	[InstanceEdit:937084] Shamovsky, V, 2010-08-25
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
crossReference	[DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	975138
displayName	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
edited	[InstanceEdit:1014292] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - Homo sapiens [Pathway:R-HSA-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation - Homo sapiens [Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens [Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation - Homo sapiens [Reaction:R-HSA-166869] TRAF6 binds MEKK1 - Homo sapiens [Pathway:R-HSA-450294] MAP kinase activation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:2445180] Essential role for IKK? in production of type 1 interferons by plasmacytoid dendritic cells [LiteratureReference:2445219] The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation
maxDepth	6
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
orthologousEvent	[Pathway:R-MMU-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Mus musculus [Pathway:R-RNO-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Rattus norvegicus [Pathway:R-CFA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Canis familiaris [Pathway:R-BTA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Bos taurus [Pathway:R-SSC-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Sus scrofa [Pathway:R-DRE-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Danio rerio [Pathway:R-XTR-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Xenopus tropicalis [Pathway:R-GGA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Gallus gallus [Pathway:R-DME-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Drosophila melanogaster [Pathway:R-CEL-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Caenorhabditis elegans [Pathway:R-DDI-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Dictyostelium discoideum [Pathway:R-SPO-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Schizosaccharomyces pombe [Pathway:R-SCE-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Saccharomyces cerevisiae [Pathway:R-PFA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Plasmodium falciparum
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-975138
summation	[Summation:975184] TRAF6 mediates NFkB activation via canonical phosphorylation...
updateTrackers	[UpdateTracker:9784369] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v54:[updateContainedPathway] [UpdateTracker:9778256] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v68:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787581] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v44:[updateIndirectRLE] [UpdateTracker:9789677] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v37:[updateIndirectRLE] [UpdateTracker:9781687] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v60:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9788464] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v42:[addLiteratureReference, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784760] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v53:[updateContainedPathway] [UpdateTracker:9783063] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v57:[updateIndirectRLE] [UpdateTracker:9788770] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v40:[updateIndirectRLE] [UpdateTracker:9789157] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v38:[updateContainedPathway] [UpdateTracker:9785033] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v52:[updateContainedPathway] [UpdateTracker:9779395] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v65:[updateIndirectRLE] [UpdateTracker:9775724] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v78:[updateIndirectRLE] [UpdateTracker:9782124] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v59:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9775000] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v80:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9776300] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v76:[updateIndirectRLE] [UpdateTracker:9788183] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v43:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9788545] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v41:[updateContainedRLE] [UpdateTracker:9789999] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v36:[updateIndirectRLE] [UpdateTracker:9774704] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v81:[updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome

(updatedInstance)

[UpdateTracker:9784369] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v54:[updateContainedPathway]
[UpdateTracker:9778256] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v68:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9787581] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v44:[updateIndirectRLE]
[UpdateTracker:9789677] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v37:[updateIndirectRLE]
[UpdateTracker:9781687] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v60:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788464] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v42:[addLiteratureReference, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784760] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v53:[updateContainedPathway]
[UpdateTracker:9783063] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v57:[updateIndirectRLE]
[UpdateTracker:9788770] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v40:[updateIndirectRLE]
[UpdateTracker:9789157] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v38:[updateContainedPathway]
[UpdateTracker:9785033] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v52:[updateContainedPathway]
[UpdateTracker:9779395] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v65:[updateIndirectRLE]
[UpdateTracker:9775724] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v78:[updateIndirectRLE]
[UpdateTracker:9782124] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v59:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9775000] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v80:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9776300] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v76:[updateIndirectRLE]
[UpdateTracker:9788183] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v43:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9788545] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v41:[updateContainedRLE]
[UpdateTracker:9789999] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v36:[updateIndirectRLE]
[UpdateTracker:9774704] Update Tracker - [Pathway:975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - v81:[updateContainedPathway, updateIndirectRLE]

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