Reactome | BOP1 [nucleoplasm]

BOP1 [nucleoplasm]

Stable Identifier

R-HSA-6791206

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

fullName evidence="2"Ribosome biogenesis protein BOP1, BOP1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14137 BOP1

Gene Names

BOP1, KIAA0124

Chain

chain:1-746

Reference Genes

BioGPS Gene:23246 BOP1

COSMIC (genes):BOP1 BOP1

CTD Gene:23246 BOP1

dbSNP Gene:23246 BOP1

ENSEMBL:ENSG00000261236 BOP1

ENSEMBL_homo_sapiens_GENE:ENSG00000261236.8 BOP1

HGNC:15519 BOP1

KEGG Gene (Homo sapiens):23246 BOP1

Monarch:23246 BOP1

NCBI Gene:23246 BOP1

OMIM:610596 BOP1

UCSC:Q14137 BOP1

Reference Transcript

RefSeq:NM_015201.4 BOP1

Other Identifiers

11757102_a_at

17082507

212563_PM_at

212563_at

216397_PM_s_at

216397_s_at

23246

3158191

3158192

3158193

3158194

3158195

3158196

3158197

3158198

3158199

3158200

3158201

3158203

3158204

3158205

3158206

3158207

3158219

3158220

3158222

3158223

3158224

3158225

3158226

3158227

3158228

3158229

3158231

3158232

3158234

3158235

3158236

3158237

3158239

3158257

3158258

3158269

3158270

3158271

3158274

3158275

35615_at

8153664

8153678

A_23_P43800

D50914_at

GE57252

GO:0000027

GO:0000448

GO:0000463

GO:0000466

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006364

GO:0008283

GO:0023052

GO:0030687

GO:0042254

GO:0042273

GO:0043021

GO:0043226

GO:0051726

GO:0065003

GO:0070545

GO:1901796

GO:1990904

HMNXSV003026658

Hs.30736.0.S1_3p_at

Hs.30736.1.S1_3p_a_at

ILMN_1763955

PH_hs_0026681

TC08001743.hg

TC08001744.hg

Participates

as a component of

PeBoW complex [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)

Inferred To

erb1 [nucleoplasm] (Schizosaccharomyces pombe)

BOP1 [nucleoplasm] (Bos taurus)

BOP1 [nucleoplasm] (Caenorhabditis elegans)

BOP1 [nucleoplasm] (Canis familiaris)

BOP1 [nucleoplasm] (Dictyostelium discoideum)

BOP1 [nucleoplasm] (Drosophila melanogaster)

BOP1 [nucleoplasm] (Gallus gallus)

BOP1 [nucleoplasm] (Sus scrofa)

ERB1 [nucleoplasm] (Saccharomyces cerevisiae)

bop1 [nucleoplasm] (Danio rerio)

bop1 [nucleoplasm] (Xenopus tropicalis)

Bop1 [nucleoplasm] (Mus musculus)

Bop1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_056016.1

OpenTargets

ENSG00000261236

GeneCards

Q14137

HPA

ENSG00000261236-BOP1

Ensembl

ENST00000569669, ENSP00000455106, ENSG00000261236

PRO

Q14137

Pharos - Targets

Q14137

PDB

8FKR, 8FKU, 8FKS, 8FKP, 8FKX, 8FKY, 8FKQ, 8FKV, 8FKW, 8FKT

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00541 PES1	1	PES1 [nucleoplasm] (R-HSA-6791207)	0.758	6
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.706	4
UniProt:Q9GZL7 WDR12	1	WDR12 [nucleoplasm] (R-HSA-6791215)	0.597	4
UniProt:Q8N0W7 FMR1N			0.527	2
UniProt:O75607 NPM3			0.527	3
UniProt:Q9H6Y2 WDR55			0.527	2
UniProt:O14958 CASQ2	1	CASQ2 [sarcoplasmic reticulum membrane] (R-HSA-2855225)	0.527	2
UniProt:Q96HE9 PRR11			0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	4

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