Reactome | EIF3C [cytosol]

EIF3C [cytosol]

Stable Identifier

R-HSA-72550

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF3c, eIF3 p110, eukaryotic translation initiation factor 3 subunit 8, Eukaryotic translation initiation factor 3 subunit 8

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99613 EIF3C

Gene Names

EIF3C, EIF3S8

Chain

chain:1-913

Reference Genes

BioGPS Gene:8663 EIF3C

COSMIC (genes):EIF3C EIF3C

CTD Gene:8663 EIF3C

dbSNP Gene:8663 EIF3C

ENSEMBL:ENSG00000184110 EIF3C

HGNC:3279 EIF3C

KEGG:hsa:8663 EIF3C

Monarch:8663 EIF3C

NCBI Gene:8663 EIF3C

OMIM:603916 EIF3C

UCSC:Q99613 EIF3C

Reference Transcript

Other Identifiers

11730724_s_at

11741662_a_at

11741663_x_at

11747865_s_at

11755846_s_at

16817363

16825306

200647_PM_x_at

200647_x_at

210949_PM_s_at

210949_s_at

215230_PM_x_at

215230_x_at

236700_PM_at

236700_at

34841_at

3654543

3654546

3654547

3654548

3654549

3654550

3654551

3654552

3654553

3654554

3654555

3654556

3654557

3654558

3654559

3654561

3654562

3654563

3654564

3654565

3654566

3654567

3654568

3654569

3654570

3654571

3654572

3654573

3654574

3654575

3654576

3654579

3654580

3654581

3654582

3654583

3654586

3654588

3654589

3654590

3654591

3654921

3655002

3686501

3686504

3686505

3686506

3686508

3686510

3686511

3686512

3686513

3686514

3686515

3686516

3686517

3686518

3686519

3686520

3686521

3686522

3686523

3686524

3686525

3686526

3686527

3686530

3686531

3686532

3686533

3686534

3686535

3686536

3686537

3686538

3686539

3686540

3686541

3686542

3686545

3686550

728689

79411_at

7994415

8000507

8663

89988_at

A_23_P77568

A_23_P77572

A_33_P3421733

GE61352

GE705641

GE725454

GO:0001732

GO:0002183

GO:0003723

GO:0003743

GO:0005515

GO:0005737

GO:0005829

GO:0005852

GO:0006412

GO:0006413

GO:0016282

GO:0031369

GO:0032991

GO:0033290

GO:0043022

GO:0045182

GO:0045727

GO:0065003

GO:1902416

HMNXSV003053297

HMNXSV003054791

Hs.192425.0.A1_3p_at

ILMN_1660942

ILMN_1700723

ILMN_1725984

ILMN_1755277

ILMN_1802139

PH_hs_0034859

TC16000305.hg

TC16000986.hg

TC16001472.hg

U46025_at

g12653522_3p_a_at

g12653522_3p_x_at

g5579457_3p_a_at

Participates

as a component of

eIF3 subunits complex [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of EIF3C [cytosol] (Gallus gallus)

nip1 [cytosol] (Schizosaccharomyces pombe)

NIP1 [cytosol] (Saccharomyces cerevisiae)

eif3C [cytosol] (Dictyostelium discoideum)

eif3c [cytosol] (Danio rerio)

eif3c [cytosol] (Xenopus tropicalis)

eif-3.C [cytosol] (Caenorhabditis elegans)

LOC479795 [cytosol] (Canis familiaris)

Eif3c [cytosol] (Mus musculus)

Eif3c [cytosol] (Rattus norvegicus)

EIF3C [cytosol] (Bos taurus)

EIF3C [cytosol] (Plasmodium falciparum)

EIF3C [cytosol] (Sus scrofa)

eIF3c [cytosol] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000184110

ENSEMBL

ENSP00000456416, ENSP00000457418, ENSP00000332604, ENSP00000378953, ENST00000395587, ENST00000566501, ENST00000566866, ENST00000564243, ENSG00000184110, ENSP00000457963, ENST00000331666

HPA

ENSG00000184110-EIF3C

GeneCards

EIF3C

PRO

Q99613

Pharos - Targets

Q99613

GlyGen

Q99613

PDB

8RG0, 7A09, 3J8B, 8OZ0, 8PJ1, 3J8C, 9BLN, 8PJ5, 8PJ3, 6ZMW, 8PJ2, 8PJ4, 6ZON, 8XXN, 8PJ6, 6YBW, 8PPL, 6YBD, 7QP7, 7QP6, 6ZP4

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16659 MAPK6 gene	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.547	2
UniProt:O95714 HERC2	5	HERC2 [nucleoplasm] (R-HSA-4551680) p-T4827-HERC2 [nucleoplasm] (R-HSA-5682601) p-T4827,SUMO1-HERC2 [nucleoplasm] (R-HSA-5682615) HERC2 [cytosol] (R-HSA-975975) monoSUMO1-HERC2 [nucleoplasm] (R-HSA-4551758)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.527	2
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934)	0.527	2
UniProt:P47813 EIF1AX	1	EIF1AX [cytosol] (R-HSA-72557)	0.525	2