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EIF3C [cytosol]
Stable Identifier
R-HSA-72550
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF3c, eIF3 p110, eukaryotic translation initiation factor 3 subunit 8, Eukaryotic translation initiation factor 3 subunit 8
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3C [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99613 EIF3C
Gene Names
EIF3C, EIF3S8
Chain
chain:1-913
Reference Genes
BioGPS Gene:8663 EIF3C
COSMIC (genes):EIF3C EIF3C
CTD Gene:8663 EIF3C
dbSNP Gene:8663 EIF3C
ENSEMBL:ENSG00000184110.15 EIF3C
HGNC:3279 EIF3C
KEGG Gene (Homo sapiens):8663 EIF3C
Monarch:8663 EIF3C
NCBI Gene:8663 EIF3C
OMIM:603916 EIF3C
UCSC:Q99613 EIF3C
Reference Transcript
RefSeq:NM_001267574.2 EIF3C
RefSeq:NM_001199142.1 EIF3C
RefSeq:NM_001037808.2 EIF3C
RefSeq:NM_003752.4 EIF3C
RefSeq:NM_001286478.1 EIF3C
Other Identifiers
11730724_s_at
11741662_a_at
11741663_x_at
11747865_s_at
11755846_s_at
16817363
16825306
200647_PM_x_at
200647_x_at
210949_PM_s_at
210949_s_at
215230_PM_x_at
215230_x_at
34841_at
3654543
3654546
3654547
3654548
3654549
3654550
3654551
3654552
3654553
3654554
3654555
3654556
3654557
3654558
3654562
3654565
3654566
3654567
3654568
3654569
3654570
3654571
3654572
3654573
3654575
3654576
3654579
3654581
3654583
3654586
3654588
3654589
3654590
3655002
3686504
3686505
3686506
3686508
3686510
3686511
3686513
3686514
3686516
3686517
3686518
3686519
3686520
3686521
3686522
3686523
3686526
3686530
3686531
3686532
3686533
3686534
3686535
3686536
3686537
3686538
3686539
3686540
3686541
3686542
3686545
728689
7994415
8000507
8663
89988_at
A_23_P77568
A_23_P77572
A_33_P3421733
GE61352
GO:0001732
GO:0002181
GO:0002183
GO:0003723
GO:0003743
GO:0005515
GO:0005737
GO:0005829
GO:0005852
GO:0006412
GO:0006413
GO:0016282
GO:0031369
GO:0032991
GO:0033290
GO:0043022
GO:0045182
GO:0045727
GO:0065003
GO:1902416
HMNXSV003054791
ILMN_1700723
ILMN_1725984
ILMN_1755277
PH_hs_0034859
TC16000305.hg
TC16000986.hg
TC16001472.hg
U46025_at
g12653522_3p_a_at
g12653522_3p_x_at
g5579457_3p_a_at
Participates
as a component of
eIF3 subunits complex [cytosol] (Homo sapiens)
Inferred To
Ghost homologue of EIF3C [cytosol]
(Gallus gallus)
nip1 [cytosol]
(Schizosaccharomyces pombe)
NIP1 [cytosol]
(Saccharomyces cerevisiae)
eif3C [cytosol]
(Dictyostelium discoideum)
eif3c [cytosol]
(Danio rerio)
eif3c [cytosol]
(Xenopus tropicalis)
eif-3.C [cytosol]
(Caenorhabditis elegans)
Eif3c [cytosol]
(Mus musculus)
Eif3c [cytosol]
(Rattus norvegicus)
EIF3C [cytosol]
(Bos taurus)
EIF3C [cytosol]
(Canis familiaris)
EIF3C [cytosol]
(Plasmodium falciparum)
EIF3C [cytosol]
(Sus scrofa)
eIF3c [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_003743.1
,
NP_001032897.1
,
NP_001273407.1
,
NP_001254503.1
,
NP_001186071.1
OpenTargets
ENSG00000184110
GeneCards
Q99613
HPA
ENSG00000184110-EIF3C
Ensembl
ENST00000331666
,
ENSP00000456416
,
ENSP00000457418
,
ENSP00000378953
,
ENSG00000184110
,
ENST00000564243
,
ENSP00000457963
,
ENSP00000332604
,
ENST00000566501
,
ENST00000395587
,
ENST00000566866
PRO
Q99613
Pharos - Targets
Q99613
PDB
7QP6
,
3J8B
,
6ZON
,
6YBW
,
6ZP4
,
6YBD
,
7A09
,
6ZMW
,
7QP7
,
3J8C
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16659 MAPK6
6
ub-MAPK6 [cytosol]
(R-HSA-5687000)
MAPK6 [cytosol]
(R-HSA-5686979)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
0.547
2
UniProt:P47813 EIF1AX
1
EIF1AX [cytosol]
(R-HSA-72557)
0.525
2
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