Reactome | CMAS [nucleoplasm]

CMAS [nucleoplasm]

Stable Identifier

R-HSA-4085417

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

N-acylneuraminate cytidylyltransferase ecNumber2.7.7.43/ecNumber, NEUA_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Homo sapiens)
        
        CMAS tetramer [nucleoplasm] (Homo sapiens)
        
        CMAS [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NFW8 CMAS

Gene Names

CMAS

Chain

chain:1-434

Reference Genes

BioGPS Gene:55907 CMAS

COSMIC (genes):CMAS CMAS

CTD Gene:55907 CMAS

dbSNP Gene:55907 CMAS

ENSEMBL:ENSG00000111726 CMAS

HGNC:18290 CMAS

KEGG:hsa:55907 CMAS

Monarch:55907 CMAS

NCBI Gene:55907 CMAS

OMIM:603316 CMAS

UCSC:Q8NFW8 CMAS

Reference Transcript

RefSeq:NM_018686.5 CMAS

Other Identifiers

11716699_a_at

11748820_x_at

16749162

218111_PM_s_at

218111_s_at

3407927

3407928

3407929

3407930

3407932

3407933

3407935

3407937

3407938

3407939

3407940

3407942

3407943

3407956

55907

57054_f_at

65156_at

74970_r_at

7954407

A_14_P122451

A_32_P73045

GE62915

GE78951

GO:0003824

GO:0005634

GO:0005654

GO:0006054

GO:0006055

GO:0008781

GO:0016020

GO:0016740

GO:0016779

GO:0043226

GO:0055086

GO:0070085

GO:1901135

HMNXSV003009388

ILMN_1714082

ILMN_2125374

PH_hs_0023722

PH_hs_0032627

TC12000237.hg

g8923899_3p_at

g8923899_3p_s_at

Participates

as a component of

CMAS tetramer [nucleoplasm] (Homo sapiens)

Inferred To

cmas [nucleoplasm] (Xenopus tropicalis)

CMAS [nucleoplasm] (Bos taurus)

CMAS [nucleoplasm] (Canis familiaris)

CMAS [nucleoplasm] (Danio rerio)

CMAS [nucleoplasm] (Gallus gallus)

CMAS [nucleoplasm] (Mus musculus)

CMAS [nucleoplasm] (Rattus norvegicus)

CMAS [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_061156.1

ENSEMBL

ENST00000534981, ENSP00000446239, ENST00000229329, ENSP00000229329, ENSG00000111726

OpenTargets

ENSG00000111726

IntEnz

2.7.7.43

GeneCards

CMAS

HPA

ENSG00000111726-CMAS

PRO

Q8NFW8

Pharos - Targets

Q8NFW8

GlyGen

Q8NFW8

HMDB Protein

HMDBP00399

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48059 LIMS1	1	LIMS1 [cytosol] (R-HSA-432859)	0.527	3
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2

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