Reactome | PBRM1 [nucleoplasm]

PBRM1 [nucleoplasm]

Stable Identifier

R-HSA-389254

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BAF180

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds the SWI/SNF complex (Homo sapiens)
        
        RUNX1:CBFB:SWI/SNF [nucleoplasm] (Homo sapiens)
        
        SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
        
        SWI/SNF additional components [nucleoplasm] (Homo sapiens)
        
        PBRM1 [nucleoplasm] (Homo sapiens)
        
        SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
        
        SWI/SNF additional components [nucleoplasm] (Homo sapiens)
        
        PBRM1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86U86 PBRM1

Gene Names

PBRM1, BAF180, PB1

Chain

chain:1-1689

Reference Genes

BioGPS Gene:55193 PBRM1

COSMIC (genes):PBRM1 PBRM1

CTD Gene:55193 PBRM1

dbSNP Gene:55193 PBRM1

ENSEMBL:ENSG00000163939 PBRM1

ENSEMBL_homo_sapiens_GENE:ENSG00000163939.19 PBRM1

HGNC:30064 PBRM1

KEGG Gene (Homo sapiens):55193 PBRM1

Monarch:55193 PBRM1

NCBI Gene:55193 PBRM1

OMIM:606083 PBRM1

UCSC:Q86U86 PBRM1

Reference Transcript

Other Identifiers

11740171_s_at

11744007_s_at

11744956_a_at

11746482_a_at

16954856

220355_PM_s_at

220355_s_at

223238_PM_s_at

223238_s_at

223400_3p_s_at

223400_PM_s_at

223400_s_at

224152_PM_s_at

224152_s_at

2676218

2676220

2676221

2676222

2676223

2676224

2676227

2676232

2676237

2676239

2676240

2676241

2676242

2676243

2676244

2676246

2676247

2676248

2676251

2676256

2676259

2676261

2676262

2676264

2676268

2676269

2676271

2676276

2676277

2676279

2676282

2676284

2676286

2676289

2676292

2676294

2676295

2676304

48990_at

55193

8087951

A_23_P218863

A_23_P365874

A_24_P362850

A_33_P3269578

A_33_P3330453

GE82345

GO:0000228

GO:0000278

GO:0000776

GO:0000785

GO:0002376

GO:0003677

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0006368

GO:0007059

GO:0007155

GO:0008285

GO:0016363

GO:0016514

GO:0016586

GO:0030071

GO:0030154

GO:0043226

GO:0045582

GO:0045597

GO:0045663

GO:0048856

GO:0070316

GO:2000045

GO:2000781

GO:2000819

HMNXSV003014810

Hs.44143.2.S2_3p_s_at

ILMN_1659470

ILMN_1723822

ILMN_2385239

PH_hs_0022841

TC03001457.hg

g11493428_3p_a_at

g12083895_3p_a_at

g8922564_3p_s_at

Participates

as a candidate of

SWI/SNF additional components [nucleoplasm] (Homo sapiens)

Inferred To

rsc4 [nucleoplasm] (Schizosaccharomyces pombe)

polybromo [nucleoplasm] (Drosophila melanogaster)

RSC2 [nucleoplasm] (Saccharomyces cerevisiae)

Pbrm1 [nucleoplasm] (Mus musculus)

Pbrm1 [nucleoplasm] (Rattus norvegicus)

pbrm-1 [nucleoplasm] (Caenorhabditis elegans)

PBRM1 [nucleoplasm] (Bos taurus)

PBRM1 [nucleoplasm] (Canis familiaris)

PBRM1 [nucleoplasm] (Gallus gallus)

PBRM1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_016862246.1, NP_060783.3, XP_016862238.1, XP_016862239.1, XP_016862247.1, XP_016862237.1, NP_851385.1

Guide to Pharmacology - Targets

2738

OpenTargets

ENSG00000163939

ZINC - Substances

PB1_HUMAN

ZINC target

Q86U86

PRO

Q86U86

PDB

6OXB, 5FH6, 5IID, 6ZN6, 3MB4, 3IU5, 5E7D, 8FTA, 5II1, 5HRX, 6ZNV, 5II2, 3LJW, 7Y8R, 3HMF, 4Q0O, 3G0J, 4Q0N, 3K2J, 5HRW, 6ZS4, 5HRV, 3TLP, 6ZS3, 4Y03, 5FH8, 5FH7, 3IU6, 2KTB, 7VDV

HPA

ENSG00000163939-PBRM1

GeneCards

Q86U86

Ensembl

ENSP00000386643, ENST00000412587, ENST00000410007, ENSP00000349213, ENSG00000163939, ENST00000356770, ENSP00000386601, ENSP00000338302, ENST00000409767, ENSP00000296302, ENSP00000386529, ENST00000394830, ENSP00000378307, ENSP00000386593, ENSP00000404579, ENST00000337303, ENST00000409057, ENST00000409114, ENST00000296302

Pharos - Targets

Q86U86

Orphanet

23288

ZINC - Predictions - Purchasable

PB1_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.802	7
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.499	2
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.483	2
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	4

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