Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
EXOSC3 [nucleoplasm]
Stable Identifier
R-HSA-6791572
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Exosome complex component RRP40, EXOS3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)
EXOSC10:C1D:MPHOSPH6:SKIV2L2:Exosome [nucleoplasm] (Homo sapiens)
Exosome core complex [nucleoplasm] (Homo sapiens)
EXOSC3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQT5 EXOSC3
Gene Names
EXOSC3, RRP40, CGI-102
Chain
initiator methionine:, chain:2-275
Reference Genes
BioGPS Gene:51010 EXOSC3
COSMIC (genes):EXOSC3 EXOSC3
CTD Gene:51010 EXOSC3
dbSNP Gene:51010 EXOSC3
ENSEMBL:ENSG00000107371 EXOSC3
ENSEMBL_homo_sapiens_GENE:ENSG00000107371.14 EXOSC3
HGNC:17944 EXOSC3
KEGG Gene (Homo sapiens):51010 EXOSC3
Monarch:51010 EXOSC3
NCBI Gene:51010 EXOSC3
OMIM:606489 EXOSC3
UCSC:Q9NQT5 EXOSC3
Reference Transcript
RefSeq:NM_001002269.2 EXOSC3
RefSeq:NM_016042.3 EXOSC3
Other Identifiers
11722587_at
11740247_s_at
11761879_at
17094044
223489_PM_x_at
223489_x_at
223490_PM_s_at
223490_s_at
227916_PM_x_at
227916_x_at
233495_PM_at
3205590
3205591
3205592
3205593
3205594
3205597
3205598
3205600
3205602
3205603
3918172
49319_s_at
51010
63613_at
8161242
86699_at
A_23_P123905
GE82068
GO:0000175
GO:0000176
GO:0000177
GO:0000178
GO:0000467
GO:0000791
GO:0002376
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006310
GO:0006364
GO:0006396
GO:0006399
GO:0006401
GO:0016071
GO:0016073
GO:0016787
GO:0034427
GO:0034475
GO:0042254
GO:0043226
GO:0043928
GO:0045006
GO:0045190
GO:0045830
GO:0048856
GO:0071034
GO:0071035
GO:0071038
GO:0071051
GO:0101019
GO:0140098
HMNXSV003032197
HMNXSV003048184
Hs.177677.0.S1_3p_a_at
Hs.177677.0.S1_3p_x_at
Hs.177677.2.A1_3p_x_at
ILMN_1708936
ILMN_1734194
PH_hs_0010555
TC09002891.hg
g8927587_3p_a_at
Participates
as a component of
Exosome core complex [nucleoplasm] (Homo sapiens)
Other forms of this molecule
EXOSC3 [cytosol]
Inferred To
exosc3 [nucleoplasm]
(Dictyostelium discoideum)
RRP40 [nucleoplasm]
(Saccharomyces cerevisiae)
exos-3 [nucleoplasm]
(Caenorhabditis elegans)
Rrp40 [nucleoplasm]
(Drosophila melanogaster)
EXOSC3 [nucleoplasm]
(Bos taurus)
EXOSC3 [nucleoplasm]
(Canis familiaris)
EXOSC3 [nucleoplasm]
(Gallus gallus)
EXOSC3 [nucleoplasm]
(Plasmodium falciparum)
EXOSC3 [nucleoplasm]
(Sus scrofa)
Exosc3 [nucleoplasm]
(Mus musculus)
Exosc3 [nucleoplasm]
(Rattus norvegicus)
rrp40 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_057126.2
,
NP_001002269.1
OpenTargets
ENSG00000107371
HPA
ENSG00000107371-EXOSC3
GeneCards
Q9NQT5
Ensembl
ENSP00000503947
,
ENST00000396521
,
ENST00000465229
,
ENSP00000418422
,
ENSP00000379775
,
ENST00000327304
,
ENST00000679059
,
ENSG00000107371
,
ENSP00000323046
PRO
Q9NQT5
Pharos - Targets
Q9NQT5
Orphanet
21174
PDB
6H25
,
2NN6
,
6D6Q
,
6D6R
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
0.901
12
UniProt:Q01780 EXOSC10
1
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
0.788
7
UniProt:Q9Y2L1 DIS3
2
DIS3 [nucleoplasm]
(R-HSA-6791517)
DIS3 [cytosol]
(R-HSA-429935)
0.744
4
UniProt:Q99547 MPHOSPH6
1
MPHOSPH6 [nucleoplasm]
(R-HSA-6791553)
0.725
6
UniProt:Q9Y580 RBM7
1
RBM7 [nucleoplasm]
(R-HSA-8985564)
0.643
4
UniProt:P42285 SKIV2L2
1
SKIV2L2 [nucleoplasm]
(R-HSA-6791189)
0.643
4
UniProt:Q13901 C1D
1
C1D [nucleoplasm]
(R-HSA-6791515)
0.527
3
UniProt:P42568 MLLT3
1
MLLT3 [nucleoplasm]
(R-HSA-8932789)
0.527
2
UniProt:Q92841 DDX17
2
DDX17 [nucleoplasm]
(R-HSA-3900090)
monoSUMO1-K50-DDX17 [nucleoplasm]
(R-HSA-3900104)
0.499
2
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.483
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text