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SENP3 [nucleoplasm]
Stable Identifier
R-HSA-2984296
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Sentrin-specific protease 3 ecNumber3.4.22.68/ecNumber, SENP3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Homo sapiens)
SENP3 [nucleoplasm] (Homo sapiens)
32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Homo sapiens)
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Homo sapiens)
SENP3 [nucleoplasm] (Homo sapiens)
32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3 [nucleoplasm] (Homo sapiens)
SENP3 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
18259216
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing
Harasim, T
,
Eick, D
,
Haindl, M
,
Muller, S
EMBO Rep.
2008
External Reference Information
External Reference
UniProt:Q9H4L4 SENP3
Gene Names
SENP3, SSP3, SUSP3
Chain
chain:1-574
Reference Genes
BioGPS Gene:26168 SENP3
COSMIC (genes):SENP3 SENP3
CTD Gene:26168 SENP3
dbSNP Gene:26168 SENP3
ENSEMBL:ENSG00000161956 SENP3
HGNC:17862 SENP3
KEGG Gene (Homo sapiens):26168 SENP3
Monarch:26168 SENP3
NCBI Gene:26168 SENP3
OMIM:612844 SENP3
UCSC:Q9H4L4 SENP3
Reference Transcript
RefSeq:NM_015670.5 SENP3
Other Identifiers
0002570047
11719733_a_at
203871_PM_at
203871_at
215113_PM_s_at
215113_s_at
26168
3708799
3708800
3708801
3708802
3708803
3708804
3708806
3708807
3708808
3708810
3708812
3708814
3708816
3708817
3708818
3708820
3708821
3708822
3708823
3708824
3708825
41633_at
8004485
A_14_P100444
A_23_P164000
GE56288
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006464
GO:0006508
GO:0008150
GO:0008233
GO:0008234
GO:0016787
GO:0016926
GO:0032991
GO:0043226
GO:0070140
GO:0071339
Hs.118926.1.S1_3p_a_at
ILMN_1751147
PH_hs_0023269
PH_hs_0032343
TC17002866.hg
g7661681_3p_at
Participates
as a component of
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Homo sapiens)
32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3 [nucleoplasm] (Homo sapiens)
Inferred To
SENP3 [nucleoplasm]
(Bos taurus)
SENP3 [nucleoplasm]
(Dictyostelium discoideum)
SENP3 [nucleoplasm]
(Sus scrofa)
ULP1 [nucleoplasm]
(Saccharomyces cerevisiae)
ulp-1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of SENP3 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of SENP3 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of SENP3 [nucleoplasm]
(Drosophila melanogaster)
Homologues of SENP3 [nucleoplasm]
(Saccharomyces cerevisiae)
senp8 [nucleoplasm]
(Dictyostelium discoideum)
EIF4A1 [nucleoplasm]
(Canis familiaris)
ULP2 [nucleoplasm]
(Saccharomyces cerevisiae)
Dmel\CG32110 [nucleoplasm]
(Drosophila melanogaster)
Senp3 [nucleoplasm]
(Mus musculus)
Senp3 [nucleoplasm]
(Rattus norvegicus)
Ulp1 [nucleoplasm]
(Drosophila melanogaster)
ulp-5 [nucleoplasm]
(Caenorhabditis elegans)
ulp1 [nucleoplasm]
(Schizosaccharomyces pombe)
senp3b [nucleoplasm]
(Danio rerio)
Ghost homologue of SENP3 [nucleoplasm]
(Gallus gallus)
Ghost homologue of SENP3 [nucleoplasm]
(Xenopus tropicalis)
ulp-2 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_056485.2
OpenTargets
ENSG00000161956
GeneCards
Q9H4L4
HPA
ENSG00000161956-SENP3
Ensembl
ENSP00000403712
,
ENST00000429205
,
ENSG00000161956
,
ENST00000321337
,
ENSP00000314029
PRO
Q9H4L4
Pharos - Targets
Q9H4L4
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06748 NPM1
10
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
0.718
6
UniProt:Q8IZL8 PELP1
1
PELP1 [nucleoplasm]
(R-HSA-3826531)
0.599
5
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-566-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-338-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-186-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-262-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-414-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-110-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-642-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-488-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.524
2
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