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SYNGAP1 [cytosol]
Stable Identifier
R-HSA-5658217
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
RAS GAPs bind RAS:GTP (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SYNGAP1 [cytosol] (Homo sapiens)
p21 RAS:GTP:RAS GAPs [plasma membrane] (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SYNGAP1 [cytosol] (Homo sapiens)
RAS GAPs stimulate RAS GTPase activity (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SYNGAP1 [cytosol] (Homo sapiens)
p21 RAS:GTP:RAS GAPs [plasma membrane] (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
SYNGAP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96PV0 SYNGAP1
Gene Names
SYNGAP1, KIAA1938
Chain
chain:1-1343
Reference Genes
BioGPS Gene:8831 SYNGAP1
COSMIC (genes):SYNGAP1 SYNGAP1
CTD Gene:8831 SYNGAP1
dbSNP Gene:8831 SYNGAP1
ENSEMBL:ENSG00000197283 SYNGAP1
ENSEMBL_homo_sapiens_GENE:ENSG00000197283.18 SYNGAP1
ENSEMBL_homo_sapiens_GENE:ENSG00000227460.8 SYNGAP1
HGNC:11497 SYNGAP1
KEGG Gene (Homo sapiens):8831 SYNGAP1
Monarch:8831 SYNGAP1
NCBI Gene:8831 SYNGAP1
OMIM:603384 SYNGAP1
UCSC:Q96PV0 SYNGAP1
Reference Transcript
RefSeq:NM_006772.2 SYNGAP1
RefSeq:NM_001130066.1 SYNGAP1
Other Identifiers
11726964_at
17007499
17007529
17041393
17041421
230297_PM_x_at
230297_x_at
234285_PM_at
234285_at
2903705
2903706
2903707
2903708
2903712
2903713
2903714
2903715
2903717
2903720
2903721
2903723
2903724
2903725
2903727
2903728
2903730
2903731
2903732
2903733
2903734
2903735
2903736
2903737
2903738
2903739
2903742
2903744
2903746
2903747
2903748
2903749
2903750
2903751
2903752
2903753
2903754
2903755
2903756
2903757
2903758
2903759
2903760
2903761
2903762
2903763
8118696
8831
89674_r_at
89675_r_at
A_24_P9346
A_33_P3324839
GE718836
GO:0005096
GO:0005515
GO:0005829
GO:0005886
GO:0007265
GO:0007389
GO:0007409
GO:0008542
GO:0012501
GO:0014069
GO:0016020
GO:0016358
GO:0017124
GO:0023052
GO:0030154
GO:0034330
GO:0043087
GO:0043113
GO:0043198
GO:0043226
GO:0043408
GO:0043524
GO:0046580
GO:0048167
GO:0048169
GO:0048856
GO:0050771
GO:0050803
GO:0050804
GO:0050877
GO:0051402
GO:0098772
GO:0098880
GO:0098978
HMNXSV003014196
Hs.302006.0.S1_3p_at
Hs.30819.1.S1_3p_at
ILMN_1704015
PH_hs_0033302
TC06000424.hg
TC6_ssto_hap7000093.hg
Participates
as a member of
RAS GAPs [cytosol] (Homo sapiens)
Inferred To
gap-2 [cytosol]
(Caenorhabditis elegans)
Syngap1 [cytosol]
(Mus musculus)
Syngap1 [cytosol]
(Rattus norvegicus)
raskol [cytosol]
(Drosophila melanogaster)
SYNGAP1 [cytosol]
(Bos taurus)
SYNGAP1 [cytosol]
(Canis familiaris)
SYNGAP1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001123538.1
,
NP_006763.2
OpenTargets
ENSG00000197283
HPA
ENSG00000197283-SYNGAP1
GeneCards
Q96PV0
Ensembl
ENSG00000197283
,
ENST00000414753
,
ENSP00000403636
,
ENSG00000227460
,
ENSP00000412475
,
ENSP00000407995
,
ENST00000629380
,
ENSP00000378509
,
ENST00000395071
,
ENST00000428982
,
ENSP00000486431
,
ENSP00000486463
,
ENSP00000496007
,
ENST00000455687
,
ENST00000628646
,
ENSP00000414259
,
ENST00000418600
,
ENST00000646630
PRO
Q96PV0
Pharos - Targets
Q96PV0
Orphanet
18361
HMDB Protein
HMDBP08175
Interactors (46)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
0.623
4
UniProt:P61371 ISL1
1
ISL1 [nucleoplasm]
(R-HSA-400478)
0.623
8
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:O95231 VENTX
1
VENTX [nucleoplasm]
(R-HSA-8853887)
0.556
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
3
UniProt:P78352 DLG4
3
DLG4 [cytosol]
(R-HSA-6794267)
DLG4 [endocytic vesicle membrane]
(R-HSA-416847)
DLG4 [plasma membrane]
(R-HSA-202135)
0.547
2
UniProt:O43602 DCX
1
DCX [cytosol]
(R-HSA-430060)
0.527
4
UniProt:P29762 CRABP1
1
SUMO-K-CRABP1 [cytosol]
(R-HSA-5334807)
0.527
4
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.527
4
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
3
UniProt:Q00839 HNRNPU
1
HNRNPU [nucleoplasm]
(R-HSA-71953)
0.527
2
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.527
6
UniProt:P62937 PPIA
5
PPIA [extracellular exosome]
(R-HSA-6801538)
PPIA [secretory granule lumen]
(R-HSA-6801400)
PPIA [extracellular region]
(R-HSA-173646)
PPIA [ficolin-1-rich granule lumen]
(R-HSA-6801391)
PPIA [cytosol]
(R-HSA-173123)
0.527
3
UniProt:Q6PKG0 LARP1
1
LARP1 [cytosol]
(R-HSA-9760421)
0.527
2
UniProt:Q6VMQ6 ATF7IP
2
me3-K16-ATF7IP [nucleoplasm]
(R-HSA-9844104)
ATF7IP [nucleoplasm]
(R-HSA-3301918)
0.527
5
UniProt:Q9UM82 SPATA2
1
SPATA2 [cytosol]
(R-HSA-9796351)
0.527
2
UniProt:Q0VG06 FAAP100
2
FAAP100 [nucleoplasm]
(R-HSA-419545)
FAAP100 [cytosol]
(R-HSA-420799)
0.527
3
UniProt:Q8NC56 LEMD2
1
LEMD2 [nuclear envelope]
(R-HSA-3067329)
0.527
2
UniProt:Q9HD42 CHMP1A
1
CHMP1A [cytosol]
(R-HSA-917721)
0.527
6
UniProt:O43633 CHMP2A
2
CHMP2A [cytosol]
(R-HSA-917734)
CHMP2A [endosome membrane]
(R-HSA-9631172)
0.527
3
UniProt:P52272 HNRNPM
1
HNRNPM [nucleoplasm]
(R-HSA-71949)
0.527
3
UniProt:Q9NQC7 CYLD
3
K48polyUb-K338, K530-CYLD [cytosol]
(R-HSA-9818664)
p-S418-CYLD [cytosol]
(R-HSA-5212667)
CYLD [cytosol]
(R-HSA-741420)
0.527
5
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.527
5
UniProt:Q96HA1 POM121
1
POM121 [nuclear envelope]
(R-HSA-157747)
0.527
2
UniProt:Q14671 PUM1
1
PUM1 [cytosol]
(R-HSA-434211)
0.527
2
UniProt:Q02880 TOP2B
2
monoSUMO1-K-TOP2B [nucleoplasm]
(R-HSA-4641297)
TOP2B [nucleoplasm]
(R-HSA-4641359)
0.527
2
UniProt:Q04837 SSBP1
1
SSBP1 [mitochondrial matrix]
(R-HSA-1592217)
0.527
3
UniProt:Q15436 SEC23A
4
p-S738,T744 SEC23A [cytosol]
(R-HSA-5685740)
SEC23A [ER to Golgi transport vesicle membrane]
(R-HSA-204024)
SEC23A [cytosol]
(R-HSA-203972)
SEC23A [endoplasmic reticulum membrane]
(R-HSA-203976)
0.527
2
UniProt:Q9Y6M1 IGF2BP2
1
IGF2BP2 [cytosol]
(R-HSA-428302)
0.527
4
UniProt:Q12906 ILF3
3
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
ILF3 [cytosol]
(R-HSA-450564)
ILF3 [nucleoplasm]
(R-HSA-9760401)
0.527
2
UniProt:Q8IZL8 PELP1
1
PELP1 [nucleoplasm]
(R-HSA-3826531)
0.527
5
UniProt:Q9H444 CHMP4B
2
CHMP4B [cytosol]
(R-HSA-917708)
CHMP4B [endosome membrane]
(R-HSA-9631202)
0.527
5
UniProt:Q9Y2W1 THRAP3
1
THRAP3 [nucleoplasm]
(R-HSA-8932115)
0.527
3
UniProt:P38606 ATP6V1A
1
ATP6V1A [cytosol]
(R-HSA-912602)
0.527
6
UniProt:Q15424 SAFB
3
SAFB [nucleoplasm]
(R-HSA-4085379)
polySUMO2,3-K231,K294-SAFB [nucleoplasm]
(R-HSA-4085357)
monoSUMO1-K231,K294-SAFB [nucleoplasm]
(R-HSA-4085343)
0.527
5
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.527
2
UniProt:O00425 IGF2BP3
1
IGF2BP3 [cytosol]
(R-HSA-428313)
0.527
4
UniProt:O75531 BANF1
4
p-T2,T3,S4-BANF1 [nucleoplasm]
(R-HSA-2993896)
BANF1 [nucleoplasm]
(R-HSA-175030)
BANF1 [cytosol]
(R-HSA-175371)
p-T2,T3,S4-BANF1 [cytosol]
(R-HSA-2995375)
0.527
5
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.527
2
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
p-MAP3K7 [cytosol]
(R-HSA-168163)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.527
3
UniProt:P53992 SEC24C
4
p-SEC24C [cytosol]
(R-HSA-5694551)
SEC24C [ER to Golgi transport vesicle membrane]
(R-HSA-204026)
SEC24C [cytosol]
(R-HSA-203988)
SEC24C [endoplasmic reticulum membrane]
(R-HSA-203987)
0.527
3
UniProt:Q12860 CNTN1
1
CNTN1 [plasma membrane]
(R-HSA-373622)
0.527
5
UniProt:Q15911 ZFHX3
1
ZFHX3 [nucleoplasm]
(R-HSA-8878084)
0.527
3
UniProt:Q15047 SETDB1
1
SETDB1 [nucleoplasm]
(R-HSA-417136)
0.527
5
UniProt:Q9NZI8 IGF2BP1
1
IGF2BP1 [cytosol]
(R-HSA-428366)
0.527
4
UniProt:O60716 CTNND1
1
CTNND1 [plasma membrane]
(R-HSA-418996)
0.499
4
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