Reactome | SYNGAP1 [cytosol]

SYNGAP1 [cytosol]

Stable Identifier

R-HSA-5658217

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96PV0 SYNGAP1

Gene Names

SYNGAP1, KIAA1938

Chain

chain:1-1343

Reference Genes

BioGPS Gene:8831 SYNGAP1

COSMIC (genes):SYNGAP1 SYNGAP1

CTD Gene:8831 SYNGAP1

dbSNP Gene:8831 SYNGAP1

ENSEMBL:ENSG00000197283 SYNGAP1

HGNC:11497 SYNGAP1

KEGG:hsa:8831 SYNGAP1

Monarch:8831 SYNGAP1

NCBI Gene:8831 SYNGAP1

OMIM:603384 SYNGAP1

UCSC:Q96PV0 SYNGAP1

Reference Transcript

Other Identifiers

11726964_at

17007499

17007529

17041393

17041421

230297_PM_x_at

230297_x_at

234285_PM_at

234285_at

2903705

2903706

2903707

2903708

2903712

2903713

2903714

2903715

2903716

2903717

2903718

2903720

2903721

2903723

2903724

2903725

2903726

2903727

2903728

2903729

2903730

2903731

2903732

2903733

2903734

2903735

2903736

2903737

2903738

2903739

2903740

2903741

2903742

2903743

2903744

2903745

2903746

2903747

2903748

2903749

2903750

2903751

2903752

2903753

2903754

2903755

2903756

2903757

2903758

2903759

2903760

2903761

2903762

2903763

8118696

8831

89674_r_at

89675_r_at

A_24_P9346

A_33_P3324839

GE718836

GO:0005096

GO:0005515

GO:0005829

GO:0005886

GO:0007265

GO:0007389

GO:0007409

GO:0008542

GO:0014069

GO:0016020

GO:0016358

GO:0017124

GO:0043087

GO:0043113

GO:0043198

GO:0043226

GO:0043408

GO:0043524

GO:0046580

GO:0048167

GO:0048169

GO:0048856

GO:0050771

GO:0050803

GO:0050804

GO:0051402

GO:0098772

GO:0098880

GO:0098978

GO:1902531

HMNXSV003014196

Hs.302006.0.S1_3p_at

Hs.30819.1.S1_3p_at

ILMN_1704015

PH_hs_0033302

TC06000424.hg

TC6_ssto_hap7000093.hg

Participates

as a member of

RAS GAPs [cytosol] (Homo sapiens)

Inferred To

gap-2 [cytosol] (Caenorhabditis elegans)

Homologues of SYNGAP1 [cytosol] (Dictyostelium discoideum)

Syngap1 [cytosol] (Mus musculus)

Syngap1 [cytosol] (Rattus norvegicus)

syngap1b [cytosol] (Danio rerio)

raskol [cytosol] (Drosophila melanogaster)

SYNGAP1 [cytosol] (Bos taurus)

SYNGAP1 [cytosol] (Canis familiaris)

SYNGAP1 [cytosol] (Dictyostelium discoideum)

SYNGAP1 [cytosol] (Sus scrofa)

nfaA [cytosol] (Dictyostelium discoideum)

ngap [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_006763.2, XP_054212640.1, XP_047275414.1, XP_047275417.1, XP_054212635.1, XP_054212639.1, XP_054212637.1, XP_047275420.1, NP_001123538.1, XP_047275419.1

OpenTargets

ENSG00000197283

ENSEMBL

ENSP00000407995, ENST00000395071, ENSP00000378509, ENST00000414753, ENSG00000197283, ENST00000646630, ENST00000455687, ENST00000418600, ENST00000628646, ENSP00000403636, ENSP00000496007, ENSG00000227460, ENST00000428982, ENSP00000414259, ENSP00000486431, ENSP00000486463, ENST00000629380, ENSP00000412475

GeneCards

SYNGAP1

HPA

ENSG00000197283-SYNGAP1

PRO

Q96PV0

Pharos - Targets

Q96PV0

GlyGen

Q96PV0

Orphanet

SYNGAP1

HMDB Protein

HMDBP08175

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.643	4
UniProt:P61371 ISL1	1	ISL1 [nucleoplasm] (R-HSA-400478)	0.623	8
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [nucleoplasm] (R-HSA-71929) HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.623	4
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:P78352 DLG4	3	DLG4 [plasma membrane] (R-HSA-202135) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [cytosol] (R-HSA-6794267)	0.547	2
UniProt:Q12906 ILF3	3	ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [nucleoplasm] (R-HSA-9760401)	0.527	2
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.527	2
UniProt:O00425 IGF2BP3	1	IGF2BP3 [cytosol] (R-HSA-428313)	0.527	4
UniProt:Q12860 CNTN1	1	CNTN1 [plasma membrane] (R-HSA-373622)	0.527	5
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.527	5
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.527	4
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.527	2
UniProt:O43602 DCX	1	DCX [cytosol] (R-HSA-430060)	0.527	4
UniProt:P29762 CRABP1	1	SUMO-K-CRABP1 [cytosol] (R-HSA-5334807)	0.527	4
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.527	5
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.527	3
UniProt:Q15436 SEC23A	4	SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) p-S738,T744 SEC23A [cytosol] (R-HSA-5685740)	0.527	2
UniProt:Q9UM82 SPATA2	1	SPATA2 [cytosol] (R-HSA-9796351)	0.527	2
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.527	6
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	2
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.527	5
UniProt:Q9NQC7 CYLD	3	CYLD [cytosol] (R-HSA-741420) p-S418-CYLD [cytosol] (R-HSA-5212667) K48polyUb-K338, K530-CYLD [cytosol] (R-HSA-9818664)	0.527	5
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.527	3
UniProt:Q0VG06 FAAP100	2	FAAP100 [cytosol] (R-HSA-420799) FAAP100 [nucleoplasm] (R-HSA-419545)	0.527	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	3
UniProt:P53992 SEC24C	4	SEC24C [endoplasmic reticulum membrane] (R-HSA-203987) SEC24C [cytosol] (R-HSA-203988) p-SEC24C [cytosol] (R-HSA-5694551) SEC24C [ER to Golgi transport vesicle membrane] (R-HSA-204026)	0.527	3
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.527	4
UniProt:Q96HA1 POM121	1	POM121 [nuclear envelope] (R-HSA-157747)	0.527	2
UniProt:Q6VMQ6 ATF7IP	2	ATF7IP [nucleoplasm] (R-HSA-3301918) me3-K16-ATF7IP [nucleoplasm] (R-HSA-9844104)	0.527	5
UniProt:Q02880 TOP2B	2	TOP2B [nucleoplasm] (R-HSA-4641359) monoSUMO1-K-TOP2B [nucleoplasm] (R-HSA-4641297)	0.527	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.527	6
UniProt:O75531 BANF1	4	p-T2,T3,S4-BANF1 [cytosol] (R-HSA-2995375) BANF1 [cytosol] (R-HSA-175371) BANF1 [nucleoplasm] (R-HSA-175030) p-T2,T3,S4-BANF1 [nucleoplasm] (R-HSA-2993896)	0.527	5
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	2
UniProt:P38606 ATP6V1A	1	ATP6V1A [cytosol] (R-HSA-912602)	0.527	6
UniProt:Q14671 PUM1	1	PUM1 [cytosol] (R-HSA-434211)	0.527	2
UniProt:P62937 PPIA	5	PPIA [extracellular region] (R-HSA-173646) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [cytosol] (R-HSA-173123) PPIA [extracellular exosome] (R-HSA-6801538)	0.527	3
UniProt:O43633 CHMP2A	2	CHMP2A [cytosol] (R-HSA-917734) CHMP2A [endosome membrane] (R-HSA-9631172)	0.527	3
UniProt:Q9H444 CHMP4B	2	CHMP4B [cytosol] (R-HSA-917708) CHMP4B [endosome membrane] (R-HSA-9631202)	0.527	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:Q15424 SAFB	3	SAFB [nucleoplasm] (R-HSA-4085379) polySUMO2,3-K231,K294-SAFB [nucleoplasm] (R-HSA-4085357) monoSUMO1-K231,K294-SAFB [nucleoplasm] (R-HSA-4085343)	0.527	5
UniProt:O43318 MAP3K7	10	p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [endosome membrane] (R-HSA-450315) p-MAP3K7 [cytosol] (R-HSA-168163) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [plasma membrane] (R-HSA-9012677) PolyUb-MAP3K7 [cytosol] (R-HSA-6782968)	0.527	3
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.527	4
UniProt:Q04837 SSBP1	1	SSBP1 [mitochondrial matrix] (R-HSA-1592217)	0.527	3
UniProt:Q15911 ZFHX3	1	ZFHX3 [nucleoplasm] (R-HSA-8878084)	0.527	3
UniProt:O60716 CTNND1	2	CTNND1 [plasma membrane] (R-HSA-418996) p-Y-CTNND1 [plasma membrane] (R-HSA-9934835)	0.499	4
UniProt:Q8TAQ2 SMARCC2	1	SMARCC2 [nucleoplasm] (R-HSA-389263)	0.499	3

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