Reactome | NPM2 [nucleoplasm]

NPM2 [nucleoplasm]

Stable Identifier

R-HSA-9821980

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nucleoplasmin-2, NPM2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q86SE8 NPM2

Gene Names

NPM2

Chain

chain:1-214

Reference Genes

BioGPS Gene:10361 NPM2

COSMIC - genes:NPM2 NPM2

CTD Gene:10361 NPM2

dbSNP Gene:10361 NPM2

ENSEMBL:ENSG00000158806 NPM2

HGNC:7930 NPM2

KEGG:hsa:10361 NPM2

Monarch:10361 NPM2

NCBI Gene:10361 NPM2

OMIM:608073 NPM2

UCSC:Q86SE8 NPM2

Reference Transcript

Participates

as an output of

HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA (Homo sapiens)

as a component of

as an input of

NPM2 and HIRA bind p-S9-PRM1:dsDNA (Homo sapiens)

Cross References

RefSeq

NP_001400045.1, NP_877724.1, NP_001273609.1, XP_054215510.1, XP_047277176.1, NP_001400042.1, NP_001273610.1, NP_001400050.1

OpenTargets

ENSG00000158806

ENSEMBL

ENSG00000158806, ENST00000521157, ENST00000381530, ENSP00000481077, ENST00000615914, ENSP00000289820, ENSP00000429413, ENSP00000481018, ENST00000397940, ENST00000289820, ENSP00000427741, ENSP00000370941, ENST00000518119, ENSP00000381032, ENST00000621538

HPA

ENSG00000158806-NPM2

GeneCards

NPM2

PRO

Q86SE8

Pharos - Targets

Q86SE8

GlyGen

Q86SE8

PDB

3T30

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75607 NPM3			0.801	6
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.743	8
UniProt:Q9H190 SDCB2			0.666	4
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q9H4K7 MTG2			0.527	2
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.527	2

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