Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
LIN54 [nucleoplasm]
Stable Identifier
R-HSA-389103
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lin-54
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Phosphorylation of LIN52 component of MuvB by DYRK1A (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the CDC25A gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the CDC6 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the E2F1 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the PCNA gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the RBL1 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:RBL1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the TOP2A gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:TOP2A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
RBL1 gene expression is repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:RBL1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:TOP2A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 (Homo sapiens)
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p130 (RBL2) associates with MuvB to form DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Polo-like kinase mediated events (Homo sapiens)
FOXM1 binds CCNB1 promoter (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
FOXM1 binds CCNB2 promoter (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB2 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
FOXM1 binds PLK1 promoter (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:PLK1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
FOXM1 stimulates CCNB1 transcription (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
FOXM1 stimulates CCNB2 transcription (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB2 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
FOXM1 stimulates PLK1 transcription (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:PLK1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6MZP7 LIN54
Gene Names
LIN54, CXCDC1, KIAA2037
Chain
chain:1-749
Reference Genes
BioGPS Gene:132660 LIN54
COSMIC (genes):LIN54 LIN54
CTD Gene:132660 LIN54
dbSNP Gene:132660 LIN54
ENSEMBL:ENSG00000189308 LIN54
ENSEMBL_homo_sapiens_GENE:ENSG00000189308.11 LIN54
HGNC:25397 LIN54
KEGG Gene (Homo sapiens):132660 LIN54
Monarch:132660 LIN54
NCBI Gene:132660 LIN54
OMIM:613367 LIN54
UCSC:Q6MZP7 LIN54
Reference Transcript
RefSeq:NM_001115008.2 LIN54
RefSeq:NM_001288997.1 LIN54
RefSeq:NM_001115007.2 LIN54
RefSeq:XM_006714081.3 LIN54
RefSeq:XM_005262750.4 LIN54
RefSeq:XM_017007730.1 LIN54
RefSeq:NM_001288996.1 LIN54
RefSeq:XM_017007729.1 LIN54
RefSeq:NM_194282.3 LIN54
RefSeq:XM_017007728.1 LIN54
Other Identifiers
11740772_a_at
11740773_s_at
11741746_a_at
11741747_x_at
11743899_x_at
11752168_x_at
132660
16977476
235809_PM_at
235809_at
2775862
2775863
2775864
2775865
2775866
2775867
2775868
2775870
2775871
2775872
2775873
2775874
2775875
2775876
2775877
2775878
2775881
2775886
2775887
2775890
2775891
2775892
2775893
2775894
2775895
55064_at
56755_at
77849_r_at
8101411
A_23_P58382
A_33_P3851513
GE623218
GO:0001067
GO:0003677
GO:0003680
GO:0005515
GO:0005634
GO:0005654
GO:0006325
GO:0006351
GO:0006355
GO:0007049
GO:0034728
GO:0043226
GO:0046872
GO:0090571
HMNXSV003040330
Hs.96952.0.S1_3p_at
ILMN_1724062
PH_hs_0029046
PH_hs_0041153
TC04001342.hg
Participates
as a component of
p-MuvB complex [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
Inferred To
LIN54 [nucleoplasm]
(Bos taurus)
LIN54 [nucleoplasm]
(Caenorhabditis elegans)
LIN54 [nucleoplasm]
(Canis familiaris)
LIN54 [nucleoplasm]
(Danio rerio)
LIN54 [nucleoplasm]
(Dictyostelium discoideum)
LIN54 [nucleoplasm]
(Gallus gallus)
LIN54 [nucleoplasm]
(Mus musculus)
LIN54 [nucleoplasm]
(Rattus norvegicus)
LIN54 [nucleoplasm]
(Sus scrofa)
LIN54 [nucleoplasm]
(Xenopus tropicalis)
mip120 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001275925.1
,
NP_001108479.1
,
XP_016863218.1
,
NP_919258.2
,
XP_016863219.1
,
XP_006714144.1
,
XP_016863217.1
,
NP_001275926.1
,
NP_001108480.1
,
XP_005262807.1
OpenTargets
ENSG00000189308
HPA
ENSG00000189308-LIN54
GeneCards
Q6MZP7
Ensembl
ENSG00000189308
,
ENSP00000407139
,
ENST00000446851
,
ENST00000505397
,
ENST00000340417
,
ENST00000442461
,
ENSP00000398265
,
ENST00000510557
,
ENSP00000421045
,
ENST00000508171
,
ENST00000506560
,
ENSP00000427413
,
ENSP00000423475
,
ENSP00000341947
,
ENSP00000425844
PRO
Q6MZP7
Pharos - Targets
Q6MZP7
PDB
5FD3
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.725
6
UniProt:P10243 MYBL1
1
MYBL1 [nucleoplasm]
(R-HSA-389109)
0.643
3
UniProt:Q08999 RBL2
2
RBL2 [nucleoplasm]
(R-HSA-389102)
p-T401,S672,S1035-RBL2 [nucleoplasm]
(R-HSA-1226084)
0.623
10
UniProt:P10244 MYBL2
1
MYBL2 [nucleoplasm]
(R-HSA-389106)
0.564
4
UniProt:P52747 ZNF143
1
ZNF143 [nucleoplasm]
(R-HSA-83837)
0.556
3
UniProt:Q02447 SP3
3
monoSUMO1-K551-SP3 [nucleoplasm]
(R-HSA-3247472)
polySUMO2-K551-SP3 [nucleoplasm]
(R-HSA-6804456)
SP3 [nucleoplasm]
(R-HSA-2160951)
0.556
3
UniProt:Q969R5 L3MBTL2
2
L3MBTL2 [nucleoplasm]
(R-HSA-6804477)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(R-HSA-6804480)
0.527
3
UniProt:Q14188 TFDP2
1
TFDP2 [nucleoplasm]
(R-HSA-1362225)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text