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LIN54
Stable Identifier
R-HSA-389103
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lin-54
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1-G1/S phases (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Phosphorylation of LIN52 component of MuvB by DYRK1A (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the CDC25A gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the CDC6 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the E2F1 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the PCNA gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the RBL1 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:RBL1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex binds the TOP2A gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
DREAM complex:TOP2A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
RBL1 gene expression is repressed by the DREAM complex (Homo sapiens)
DREAM complex:RBL1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)
DREAM complex:TOP2A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 (Homo sapiens)
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p130 (RBL2) associates with MuvB to form DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
Activation of E2F1 target genes at G1/S (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Polo-like kinase mediated events (Homo sapiens)
FOXM1 binds CCNB1 promoter (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
FOXM1 binds CCNB2 promoter (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB2 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
FOXM1 binds PLK1 promoter (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:PLK1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
FOXM1 stimulates CCNB1 transcription (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
FOXM1 stimulates CCNB2 transcription (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB2 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
FOXM1 stimulates PLK1 transcription (Homo sapiens)
p-T611,S730,S739-FOXM1:MuvB:MYBL2:PLK1 Gene [nucleoplasm] (Homo sapiens)
MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p-MuvB complex [nucleoplasm] (Homo sapiens)
LIN54 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6MZP7 LIN54
Gene Names
LIN54, CXCDC1, KIAA2037
Chain
chain:1-749
Reference Genes
BioGPS Gene:132660 LIN54
COSMIC (genes):LIN54 LIN54
CTD Gene:132660 LIN54
dbSNP Gene:132660 LIN54
ENSEMBL:ENSG00000189308 LIN54
HGNC:25397 LIN54
KEGG Gene (Homo sapiens):hsa:132660 LIN54
Monarch:132660 LIN54
NCBI Gene:132660 LIN54
OMIM:613367 LIN54
UCSC:Q6MZP7 LIN54
Reference Transcript
RefSeq:XM_006714081.3 LIN54
RefSeq:XM_017007730.1 LIN54
RefSeq:XM_017007729.1 LIN54
RefSeq:NM_001288997.1 LIN54
RefSeq:NM_001115007.2 LIN54
RefSeq:NM_001115008.2 LIN54
RefSeq:XM_017007728.1 LIN54
RefSeq:NM_194282.3 LIN54
RefSeq:XM_005262750.4 LIN54
RefSeq:NM_001288996.1 LIN54
Other Identifiers
11740772_a_at
11740773_s_at
11741746_a_at
11741747_x_at
11743899_x_at
11752168_x_at
132660
16977476
235809_at
55064_at
56606
56755_at
5FD3
77849_r_at
8101411
A0A024RDD8
A_23_P58382
A_33_P3851513
AAI09278
AAI09279
AB111889
AC021105
AK292769
BAC98377
BAF85458
BC109277
BC109278
BX640657
BX640966
CAE45799
CAE45981
CCDS3599
CCDS47089
CCDS75157
CH471057
EAX05917
EAX05919
ENSG00000189308
ENSP00000341947
ENSP00000398265
ENSP00000407139
ENSP00000421045
ENSP00000423475
ENSP00000425844
ENSP00000427413
ENST00000340417
ENST00000442461
ENST00000446851
ENST00000505397
ENST00000506560
ENST00000508171
ENST00000510557
EntrezGene:132660
GE623218
GO:0003674
GO:0003677
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0006351
GO:0006355
GO:0007049
GO:0008150
GO:0009058
GO:0034641
GO:0043167
GO:0043226
GO:0051726
HGNC:25397
HPA056606
Hs.96952
ILMN_1724062
IPR005172
IPR028307
IPR033467
LIN54
LIN54-201
LIN54-202
LIN54-203
LIN54-204
LIN54-206
LIN54-207
LIN54-209
MIM:613367
NM_001115007
NM_001115008
NM_001288996
NM_001288997
NM_194282
NP_001108479
NP_001108480
NP_001275925
NP_001275926
NP_919258
NR_110253
PF03638
PH_hs_0029046
PH_hs_0041153
SM01114
TC04001342.hg
uc003hnx.5
uc003hnz.5
uc010ijt.4
uc010ijv.4
uc032toe.2
uc062xuy.1
uc062xuz.1
UPI00001BDB74
UPI00001D75DE
UPI00005DC766
UPI00005DC767
XM_005262750
XM_006714081
XM_017007728
XM_017007729
XM_017007730
XP_005262807
XP_006714144
XP_016863217
XP_016863218
XP_016863219
Participant Of
hasComponent
MuvB complex [nucleoplasm]
p-MuvB complex [nucleoplasm]
Inferred To
Homologues of LIN54 [nucleoplasm] (Arabidopsis thaliana)
Homologues of LIN54 [nucleoplasm] (Danio rerio)
Homologues of LIN54 [nucleoplasm] (Oryza sativa)
Homologues of LIN54 [nucleoplasm] (Sus scrofa)
LIN54 [nucleoplasm] (Arabidopsis thaliana)
LIN54 [nucleoplasm] (Bos taurus)
LIN54 [nucleoplasm] (Canis familiaris)
LIN54 [nucleoplasm] (Danio rerio)
LIN54 [nucleoplasm] (Drosophila melanogaster)
LIN54 [nucleoplasm] (Gallus gallus)
LIN54 [nucleoplasm] (Mus musculus)
LIN54 [nucleoplasm] (Oryza sativa)
LIN54 [nucleoplasm] (Rattus norvegicus)
LIN54 [nucleoplasm] (Sus scrofa)
LIN54 [nucleoplasm] (Taeniopygia guttata)
LIN54 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_001108480.1
,
NP_919258.2
,
XP_016863217.1
,
XP_016863218.1
,
NP_001275925.1
,
XP_005262807.1
,
XP_016863219.1
,
NP_001275926.1
,
XP_006714144.1
,
NP_001108479.1
GeneCards
Q6MZP7
DOCK Blaster
5FD3
PRO
Q6MZP7
PDB
5FD3
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08999 RBL2
2
p-T401,S672,S1035-RBL2 [nucleoplasm]
(R-HSA-1226084)
RBL2 [nucleoplasm]
(R-HSA-389102)
0.623
10
UniProt:P10244 MYBL2
1
MYBL2 [nucleoplasm]
(R-HSA-389106)
0.564
4
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.527
2
UniProt:Q02447 SP3
3
SUMO2-K551-SP3 [nucleoplasm]
(R-HSA-6804456)
SUMO1-K551-SP3 [nucleoplasm]
(R-HSA-3247472)
SP3 [nucleoplasm]
(R-HSA-2160951)
0.488
2
UniProt:P52747 ZNF143
1
ZNF143 [nucleoplasm]
(R-HSA-83837)
0.488
2
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