Reactome | EXOSC8 [cytosol]

EXOSC8 [cytosol]

Stable Identifier

R-HSA-429912

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Exosome complex exonuclease RRP43, EXOS8_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - PERK regulates gene expression (Homo sapiens)
      - ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
        
        Expression of IL-8 (Homo sapiens)
        
        KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
        
        Exosome Complex [cytosol] (Homo sapiens)
        
        Exosome Ring Hexamer [cytosol] (Homo sapiens)
        
        EXOSC8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96B26 EXOSC8

Gene Names

EXOSC8, OIP2, RRP43

Chain

initiator methionine:, chain:2-276

Reference Genes

BioGPS Gene:11340 EXOSC8

COSMIC (genes):EXOSC8 EXOSC8

CTD Gene:11340 EXOSC8

dbSNP Gene:11340 EXOSC8

ENSEMBL:ENSG00000120699 EXOSC8

ENSEMBL_homo_sapiens_GENE:ENSG00000120699.14 EXOSC8

HGNC:17035 EXOSC8

KEGG Gene (Homo sapiens):11340 EXOSC8

Monarch:11340 EXOSC8

NCBI Gene:11340 EXOSC8

OMIM:606019 EXOSC8

UCSC:Q96B26 EXOSC8

Reference Transcript

RefSeq:NM_181503.2 EXOSC8

Other Identifiers

11340

11717589_a_at

16774082

215136_PM_s_at

215136_s_at

2954850

3485869

3485870

3485872

3485876

3485879

3485880

3485883

3485885

3485887

3485888

3485890

3485891

3485892

36968_s_at

7968658

A_14_P110649

A_24_P241276

GE79411

GO:0000176

GO:0000177

GO:0000178

GO:0000467

GO:0001650

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006364

GO:0006396

GO:0006399

GO:0006401

GO:0016071

GO:0016073

GO:0034427

GO:0034473

GO:0034475

GO:0034476

GO:0035925

GO:0042254

GO:0042802

GO:0043226

GO:0043231

GO:0043928

GO:0071028

GO:0071035

GO:0071038

GO:0071042

GO:0101019

GO:1902494

HMNXSV003012352

Hs.274170.1.S1_3p_a_at

PH_hs_0014123

TC13001019.hg

p26668

Participates

as a component of

Exosome Ring Hexamer [cytosol] (Homo sapiens)

Other forms of this molecule

EXOSC8 [nucleoplasm]

Inferred To

exos-8 [cytosol] (Caenorhabditis elegans)

Exosc8 [cytosol] (Mus musculus)

Exosc8 [cytosol] (Rattus norvegicus)

rrp43 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of EXOSC8 [cytosol] (Drosophila melanogaster)

exosc8 [cytosol] (Xenopus tropicalis)

EXOSC8 [cytosol] (Bos taurus)

EXOSC8 [cytosol] (Canis familiaris)

EXOSC8 [cytosol] (Dictyostelium discoideum)

EXOSC8 [cytosol] (Gallus gallus)

EXOSC8 [cytosol] (Sus scrofa)

RRP43 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_852480.1

OpenTargets

ENSG00000120699

HPA

ENSG00000120699-EXOSC8

GeneCards

Q96B26

Ensembl

ENSP00000374354, ENSG00000120699, ENST00000389704

PRO

Q96B26

Pharos - Targets

Q96B26

Orphanet

23079

PDB

6D6Q, 6D6R, 2NN6, 6H25

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.948	25
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.659	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.556	3
UniProt:P15336 ATF2	2	ATF2 [nucleoplasm] (R-HSA-450336) p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.556	3
UniProt:Q9Y2L1 DIS3	2	DIS3 [nucleoplasm] (R-HSA-6791517) DIS3 [cytosol] (R-HSA-429935)	0.547	2
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.527	3
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.527	2
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.527	2
UniProt:Q99547 MPHOSPH6	1	MPHOSPH6 [nucleoplasm] (R-HSA-6791553)	0.527	4
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.483	2