Reactome | PNO1 [nucleoplasm]

PNO1 [nucleoplasm]

Stable Identifier

R-HSA-6791540

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RNA-binding protein PNO1, PNO1_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
15497447	Cloning and characterization of a novel human RNA binding protein gene PNO1 Zhou, GJ, Zhang, Y, Wang, J, Guo, JH, Ni, J, Zhong, ZM, Wang, LQ, Dang, YJ, Dai, JF, Yu, L	DNA Seq.	2004

External Reference Information

External Reference

UniProt:Q9NRX1 PNO1

Gene Names

PNO1

Chain

chain:1-252

Reference Genes

BioGPS Gene:56902 PNO1

COSMIC - genes:PNO1 PNO1

CTD Gene:56902 PNO1

dbSNP Gene:56902 PNO1

ENSEMBL:ENSG00000115946 PNO1

HGNC:32790 PNO1

KEGG:hsa:56902 PNO1

Monarch:56902 PNO1

NCBI Gene:56902 PNO1

OMIM:618710 PNO1

UCSC:Q9NRX1 PNO1

Reference Transcript

RefSeq:NM_020143.4 PNO1

Other Identifiers

11729185_at

11729186_at

11729187_x_at

16880924

203622_PM_s_at

203622_s_at

211697_3p_x_at

211697_PM_x_at

211697_x_at

242627_PM_at

242627_at

242905_PM_at

242905_at

2486743

2486744

2486745

2486746

2486747

2486748

2486749

2486751

2486752

2486753

2486754

2486755

2486756

2486757

33720_at

3588935

56902

8042381

A_14_P123500

A_24_P336853

GE82501

GO:0003676

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005829

GO:0032040

GO:0042274

HMNXSV003020359

Hs.262858.0.A1_3p_at

Hs.298694.0.A1_3p_at

ILMN_1753607

L48692_at

PH_hs_0023309

TC02000395.hg

g10047139_3p_s_at

g13540364_3p_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851 (Homo sapiens)

Other forms of this molecule

PNO1 [cytosol]

Inferred To

l(1)G0004 [nucleoplasm] (Drosophila melanogaster)

pno-1 [nucleoplasm] (Caenorhabditis elegans)

rbp28 [nucleoplasm] (Schizosaccharomyces pombe)

PNO1 [nucleoplasm] (Bos taurus)

PNO1 [nucleoplasm] (Canis familiaris)

PNO1 [nucleoplasm] (Plasmodium falciparum)

PNO1 [nucleoplasm] (Saccharomyces cerevisiae)

PNO1 [nucleoplasm] (Sus scrofa)

pno1 [nucleoplasm] (Danio rerio)

pno1 [nucleoplasm] (Dictyostelium discoideum)

pno1 [nucleoplasm] (Xenopus tropicalis)

Pno1 [nucleoplasm] (Mus musculus)

Pno1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_064528.1

OpenTargets

ENSG00000115946

ENSEMBL

ENSP00000263657, ENST00000263657, ENSG00000115946

HPA

ENSG00000115946-PNO1

GeneCards

PNO1

PRO

Q9NRX1

Pharos - Targets

Q9NRX1

GlyGen

Q9NRX1

PDB

8ZDD, 7MQA, 8ZDC, 6G4S, 6G51, 7WTT, 7WTV, 6G53, 6G18, 7WU0, 6G4W, 6ZXD, 6ZXE, 7WTU, 7WTW, 7WTZ, 6G5I, 6ZUO, 7WTX, 7MQ8, 7MQ9, 7WTS

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULX3 NOB1	2	NOB1 [nucleoplasm] (R-HSA-6791536) NOB1 [cytosol] (R-HSA-6791524)	0.742	5
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.615	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q5TAP6 UTP14C	1	UTP14C [nucleoplasm] (R-HSA-8867818)	0.527	2
UniProt:Q86VU5 CMTD1			0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2

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