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CPSF4 [nucleoplasm]
Stable Identifier
R-HSA-169104
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CPSF30, Cleavage and polyadenylation specificity factor subunit 4, Cleavage and polyadenylation specificity factor 30 kDa subunit, NEB1, NAR
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Influenza Infection (Homo sapiens)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
Inhibition of Host mRNA Processing and RNA Silencing (Homo sapiens)
Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
CPSF:NS1 Complex [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of Mature mRNA Derived from an Intronless Transcript (Homo sapiens)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Mature intronless derived mRNA complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Processing of Capped Intronless Pre-mRNA (Homo sapiens)
Processing of Intronless Pre-mRNAs (Homo sapiens)
Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)
Mature intronless derived mRNA complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Recognition of AAUAAA sequence by CPSF (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
Recruitment of CstF to the CPSF Bound Pre-mRNA (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
tRNA processing (Homo sapiens)
tRNA processing in the nucleus (Homo sapiens)
TSEN complex cleaves the intron from pre-tRNA (Homo sapiens)
TSEN complex [nucleoplasm] (Homo sapiens)
CPSF4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95639 CPSF4
Gene Names
CPSF4, CPSF30, NAR, NEB1
Chain
chain:1-269
Reference Genes
BioGPS Gene:10898 CPSF4
COSMIC (genes):CPSF4 CPSF4
CTD Gene:10898 CPSF4
dbSNP Gene:10898 CPSF4
ENSEMBL:ENSG00000160917.15 CPSF4
HGNC:2327 CPSF4
KEGG Gene (Homo sapiens):10898 CPSF4
Monarch:10898 CPSF4
NCBI Gene:10898 CPSF4
OMIM:603052 CPSF4
UCSC:O95639 CPSF4
Reference Transcript
RefSeq:NM_001318161.1 CPSF4
RefSeq:NM_001318162.1 CPSF4
RefSeq:NM_001081559.2 CPSF4
RefSeq:NM_006693.3 CPSF4
RefSeq:NM_001318160.1 CPSF4
Other Identifiers
0006860070
10898
11734082_a_at
11739169_a_at
11747753_a_at
206688_PM_s_at
206688_s_at
3014765
3014766
3014771
3014774
3014776
3014778
3014780
3014785
3014786
3014793
3014794
3014795
3014796
3014797
3014798
35743_at
8134599
A_14_P100742
A_23_P42997
GE59454
GO:0003676
GO:0003677
GO:0003723
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005847
GO:0006397
GO:0008270
GO:0016071
GO:0032991
GO:0043226
GO:0043231
GO:0046872
GO:0098789
GO:1990837
HMNXSV003004124
ILMN_1660426
ILMN_2357260
PH_hs_0025371
TC07000594.hg
g5729938_3p_a_at
Participates
as a component of
TSEN complex [nucleoplasm] (Homo sapiens)
CPSF:NS1 Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
as an input of
Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) (Homo sapiens)
Inferred To
yth1 [nucleoplasm]
(Schizosaccharomyces pombe)
Clp [nucleoplasm]
(Drosophila melanogaster)
YTH1 [nucleoplasm]
(Saccharomyces cerevisiae)
Cpsf4 [nucleoplasm]
(Mus musculus)
Cpsf4 [nucleoplasm]
(Rattus norvegicus)
cpsf-4 [nucleoplasm]
(Caenorhabditis elegans)
CPSF4 [nucleoplasm]
(Bos taurus)
CPSF4 [nucleoplasm]
(Canis familiaris)
CPSF4 [nucleoplasm]
(Danio rerio)
CPSF4 [nucleoplasm]
(Dictyostelium discoideum)
CPSF4 [nucleoplasm]
(Gallus gallus)
CPSF4 [nucleoplasm]
(Sus scrofa)
cpsf4 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001305089.1
,
NP_001305091.1
,
NP_001075028.1
,
NP_001305090.1
,
NP_006684.1
OpenTargets
ENSG00000160917
GeneCards
O95639
HPA
ENSG00000160917-CPSF4
Ensembl
ENST00000292476
,
ENSG00000160917
,
ENST00000436336
,
ENSP00000395311
,
ENSP00000292476
PRO
O95639
Pharos - Targets
O95639
PDB
6URG
,
2RHK
,
6FBS
,
6DNH
,
2D9N
,
7K95
,
6FUW
,
6URO
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P50222 MEOX2
0.556
3
IntAct:EBI-10185891 81608
0.556
3
UniProt:Q6UN15 FIP1L1
9
p-11Y FIP1L1(1-272):PDGFRA (567-1069) fusion [cytosol]
(R-HSA-9673867)
p-11Y FIP1L1(1-395):PDGFRA (577-1069) fusion [cytosol]
(R-HSA-9673879)
p-11Y FIP1L1(1-395):PDGFRA (585-1069) fusion [cytosol]
(R-HSA-9673621)
p-11Y FIP1L1(1-339):PDGFRA (580-1069) fusion [cytosol]
(R-HSA-9673872)
FIP1L1(1-395):PDGFRA (585-1069) fusion [cytosol]
(R-HSA-9672506)
FIP1L1(1-395):PDGFRA (577-1069) fusion [cytosol]
(R-HSA-9672502)
FIP1L1(1-272):PDGFRA (567-1069) fusion [cytosol]
(R-HSA-9672496)
FIP1L1(1-339):PDGFRA (580-1069) fusion [cytosol]
(R-HSA-9672499)
FIP1L1 [nucleoplasm]
(R-HSA-6805150)
0.547
2
UniProt:Q9UKF6 CPSF3
1
CPSF3 [nucleoplasm]
(R-HSA-71993)
0.527
2
UniProt:Q194T2 Q194T2
0.499
5
UniProt:I6T1Z2 I6T1Z2
0.499
5
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.499
3
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