Reactome | CPSF4 [nucleoplasm]

CPSF4 [nucleoplasm]

Stable Identifier

R-HSA-169104

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CPSF

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF4 [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF4 [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF4 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95639 CPSF4

Gene Names

CPSF4, CPSF30, NAR, NEB1

Chain

chain:1-269

Reference Genes

BioGPS Gene:10898 CPSF4

COSMIC (genes):CPSF4 CPSF4

CTD Gene:10898 CPSF4

dbSNP Gene:10898 CPSF4

ENSEMBL:ENSG00000160917 CPSF4

HGNC:2327 CPSF4

KEGG Gene (Homo sapiens):10898 CPSF4

Monarch:10898 CPSF4

NCBI Gene:10898 CPSF4

OMIM:603052 CPSF4

UCSC:O95639 CPSF4

Reference Transcript

Other Identifiers

0006860070

10898

11734082_a_at

11739169_a_at

11747753_a_at

206688_s_at

3014765

3014766

3014771

3014774

3014776

3014778

3014780

3014785

3014786

3014793

3014794

3014795

3014796

3014797

3014798

35743_at

8134599

A_14_P100742

A_23_P42997

GE59454

GO:0000398

GO:0003674

GO:0003676

GO:0003677

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005847

GO:0006369

GO:0006388

GO:0006397

GO:0006399

GO:0006406

GO:0006810

GO:0006913

GO:0008150

GO:0008270

GO:0009058

GO:0015031

GO:0016032

GO:0031124

GO:0032991

GO:0034641

GO:0043167

GO:0043226

GO:0043231

GO:0044403

GO:0046778

GO:0046872

GO:0098789

GO:1990837

ILMN_1660426

ILMN_2357260

PH_hs_0025371

TC07000594.hg

g5729938_3p_a_at

Participant Of

hasComponent

input

Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)

Inferred To

yth1 [nucleoplasm] (Schizosaccharomyces pombe)

Clp [nucleoplasm] (Drosophila melanogaster)

YTH1 [nucleoplasm] (Saccharomyces cerevisiae)

Cpsf4 [nucleoplasm] (Mus musculus)

Cpsf4 [nucleoplasm] (Rattus norvegicus)

cpsf-4 [nucleoplasm] (Caenorhabditis elegans)

CPSF4 [nucleoplasm] (Canis familiaris)

CPSF4 [nucleoplasm] (Dictyostelium discoideum)

CPSF4 [nucleoplasm] (Gallus gallus)

CPSF4 [nucleoplasm] (Sus scrofa)

cpsf4 [nucleoplasm] (Danio rerio)

cpsf4 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of CPSF4 [nucleoplasm] (Bos taurus)

Cross References

RefSeq

NP_001305090.1, NP_001305091.1, NP_001305089.1, NP_006684.1, NP_001075028.1

OpenTargets

ENSG00000160917

GeneCards

O95639

HPA

ENSG00000160917-CPSF4

Ensembl

ENST00000436336, ENSP00000292476, ENSP00000395311, ENSG00000160917, ENST00000292476

PRO

O95639

PDB

6FBS, 2RHK, 6URO, 6DNH, 2D9N, 6URG, 6FUW

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50222 MEOX2			0.556	3
IntAct:EBI-10185891 81608			0.556	3
UniProt:Q6UN15 FIP1L1	9	p-11Y FIP1L1(1-395):PDGFRA (577-1069) fusion [cytosol] (R-HSA-9673879) p-11Y FIP1L1(1-272):PDGFRA (567-1069) fusion [cytosol] (R-HSA-9673867) p-11Y FIP1L1(1-395):PDGFRA (585-1069) fusion [cytosol] (R-HSA-9673621) p-11Y FIP1L1(1-339):PDGFRA (580-1069) fusion [cytosol] (R-HSA-9673872) FIP1L1(1-395):PDGFRA (585-1069) fusion [cytosol] (R-HSA-9672506) FIP1L1(1-395):PDGFRA (577-1069) fusion [cytosol] (R-HSA-9672502) FIP1L1(1-272):PDGFRA (567-1069) fusion [cytosol] (R-HSA-9672496) FIP1L1(1-339):PDGFRA (580-1069) fusion [cytosol] (R-HSA-9672499) FIP1L1 [nucleoplasm] (R-HSA-6805150)	0.547	2
UniProt:Q9UKF6 CPSF3	1	CPSF3 [nucleoplasm] (R-HSA-71993)	0.527	2
UniProt:Q194T2 Q194T2			0.499	5
UniProt:I6T1Z2 I6T1Z2			0.499	5
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.499	3

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