Reactome | p-EIF2AK2 [nucleoplasm]

p-EIF2AK2 [nucleoplasm]

Stable Identifier

R-HSA-9836332

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PKR, Double stranded RNA activated protein kinase (PKR)

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P19525 EIF2AK2

Gene Names

EIF2AK2, PKR, PRKR

Chain

initiator methionine:, chain:2-551

Reference Genes

BioGPS Gene:5610 EIF2AK2

COSMIC (genes):EIF2AK2 EIF2AK2

CTD Gene:5610 EIF2AK2

dbSNP Gene:5610 EIF2AK2

ENSEMBL:ENSG00000055332 EIF2AK2

ENSEMBL_homo_sapiens_GENE:ENSG00000055332.19 EIF2AK2

HGNC:9437 EIF2AK2

KEGG Gene (Homo sapiens):5610 EIF2AK2

Monarch:5610 EIF2AK2

NCBI Gene:5610 EIF2AK2

OMIM:176871 EIF2AK2

UCSC:P19525 EIF2AK2

Reference Transcript

Other Identifiers

1008_f_at

11730991_a_at

11730992_x_at

16896442

204211_PM_x_at

204211_x_at

213294_PM_at

213294_at

238743_PM_at

238743_at

242898_PM_at

242898_at

2548403

2548404

2548405

2548406

2548407

2548408

2548409

2548410

2548412

2548414

2548417

2548418

2548420

2548421

2548422

2548426

2548427

2548428

2548429

2548430

2548431

2548433

2548434

2548435

2548436

2548441

38662_at

5610

61940_at

80047_at

8051501

85147_at

A_19_P00804527

A_32_P38003

A_33_P3224858

GE61104

GO:0000166

GO:0001819

GO:0002376

GO:0003723

GO:0003725

GO:0003824

GO:0004672

GO:0004674

GO:0004694

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0006351

GO:0006355

GO:0006412

GO:0006468

GO:0008285

GO:0009615

GO:0012501

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0017148

GO:0019888

GO:0023052

GO:0030154

GO:0030968

GO:0032722

GO:0032874

GO:0033689

GO:0034198

GO:0035455

GO:0036211

GO:0042802

GO:0043066

GO:0043226

GO:0043410

GO:0045071

GO:0045087

GO:0045182

GO:0046777

GO:0048471

GO:0048856

GO:0051092

GO:0051607

GO:0065003

GO:0098542

GO:0098772

GO:0106310

GO:0140096

GO:0140374

GO:1900225

GO:1901224

GO:1901532

GO:1902033

GO:1902036

HMNXSV003049578

Hs.169816.0.A1_3p_at

Hs.271866.0.A1_3p_at

Hs.306117.1.A1_3p_at

ILMN_1706502

PH_hs_0025752

TC02001739.hg

TC02004161.hg

U50648_s_at

g4506102_3p_at

Participates

as a component of

p-EIF2AK2 dimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

SUMO-EIF2AK2 [cytosol]

ISG15-EIF2AK2 [cytosol]

p-EIF2AK2 [cytosol]

EIF2AK2 [cytosol]

Inferred To

phospho-p-EIF2AK2 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-EIF2AK2 [nucleoplasm] (Canis familiaris)

phospho-p-EIF2AK2 [nucleoplasm] (Danio rerio)

phospho-p-EIF2AK2 [nucleoplasm] (Drosophila melanogaster)

phospho-p-EIF2AK2 [nucleoplasm] (Gallus gallus)

phospho-p-EIF2AK2 [nucleoplasm] (Mus musculus)

phospho-p-EIF2AK2 [nucleoplasm] (Rattus norvegicus)

phospho-p-EIF2AK2 [nucleoplasm] (Sus scrofa)

phospho-p-EIF2AK2 [nucleoplasm] (Xenopus tropicalis)

phospho-EIF2AK2 [nucleoplasm] (Bos taurus)

Modified Residues

Name

O-phospho-L-threonine at 88

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 89

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 90

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 101

Coordinate

101

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 162

Coordinate

162

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-serine at 242

Coordinate

242

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 255

Coordinate

255

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 258

Coordinate

258

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 293

Coordinate

293

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-threonine at 446

Coordinate

446

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 451

Coordinate

451

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_002750.1, NP_001129124.1, NP_001129123.1, XP_011531289.1

Guide to Pharmacology - Targets

2016

OpenTargets

ENSG00000055332

IntEnz

2.7.11.1, 2.7.10.2

GeneCards

P19525

HPA

ENSG00000055332-EIF2AK2

ZINC target

P19525

Ensembl

ENSP00000233057, ENSP00000497534, ENSP00000505138, ENST00000681463, ENSP00000385014, ENSP00000506024, ENST00000405334, ENSP00000505772, ENSG00000055332, ENST00000233057, ENST00000681507, ENSP00000378559, ENST00000395127, ENST00000647926, ENST00000679507

PRO

P19525

Pharos - Targets

P19525

HMDB Protein

HMDBP08840

PDB

6D3K, 1QU6, 8BI7, 6D3L, 7OBL, 8I9J, 7OBK, 2A19, 8IZN, 3UIU, 2A1A

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.822	8
UniProt:O75569 PRKRA	2	p-S246,S287-PRKRA [cytosol] (R-HSA-9834791) PRKRA [cytosol] (R-HSA-2399897)	0.8	6
UniProt:P05198 EIF2S1	2	p-S52-EIF2S1 [cytosol] (R-HSA-381060) EIF2S1 [cytosol] (R-HSA-72510)	0.783	5
UniProt:Q9UL40 ZN346			0.708	4
UniProt:Q7L2E3 DHX30			0.708	4
UniProt:P27958-PRO_0000037576			0.698	5
UniProt:P27958-PRO_0000037570			0.684	4
UniProt:P20639 PG041			0.667	3
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.623	3
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.623	4
UniProt:Q9NUL3 STAU2			0.623	3
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.623	3
UniProt:Q12906 ILF3	3	p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [cytosol] (R-HSA-450564) ILF3 [nucleoplasm] (R-HSA-9760401)	0.615	3
UniProt:Q96P20 NLRP3	2	K63polyUb-NLRP3 [cytosol] (R-HSA-6783288) NLRP3 [cytosol] (R-HSA-561189)	0.602	6
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.602	4
UniProt:Q27968 DNJC3			0.591	5
UniProt:P04487 RNB			0.591	3
UniProt:P19525 EIF2AK2	5	p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) p-EIF2AK2 [cytosol] (R-HSA-9833834) EIF2AK2 [cytosol] (R-HSA-168699)	0.558	2
UniProt:P78563-4 ADARB1			0.556	3
UniProt:O75569-1 PRKRA			0.544	3
UniProt:Q9NZM5 NOP53			0.527	2
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.527	2
UniProt:P51608 MECP2			0.527	2
UniProt:Q8WTT2 NOC3L			0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	2
UniProt:Q14684 RRP1B			0.527	2
UniProt:P55265 ADAR	2	ADAR [nucleoplasm] (R-HSA-53939) ADAR1 [cytosol] (R-HSA-9835955)	0.527	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	2
UniProt:Q96SL4 GPX7	1	GPX7 [endoplasmic reticulum lumen] (R-HSA-3341316)	0.527	2
UniProt:Q9NX58 LYAR			0.527	2
UniProt:Q9BZE4 GTPB4			0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:O75683 SURF6			0.527	2
UniProt:O95793 STAU1			0.527	2
UniProt:Q00577 PURA			0.527	2
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.527	2
UniProt:P04798 CYP1A1	1	CYP1A1 [endoplasmic reticulum membrane] (R-HSA-52623)	0.527	2
UniProt:Q6P2E9 EDC4	1	EDC4 [cytosol] (R-HSA-429963)	0.499	2
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.499	2
UniProt:P56537 IF6			0.499	2
UniProt:Q15633 TARBP2	2	TARBP2 [cytosol] (R-HSA-203864) p-TARBP2 [cytosol] (R-HSA-9835348)	0.499	2
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.499	2
UniProt:Q96C10 DHX58	1	DHX58 [cytosol] (R-HSA-913540)	0.499	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2

Cite Us!