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WHSC1 [nucleoplasm]
Stable Identifier
R-HSA-1183215
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Probable histone-lysine N-methyltransferase NSD2, NSD2_HUMAN, KMT3G, NSD2
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)
WHSC1, WHSC1L1 [nucleoplasm] (Homo sapiens)
WHSC1 [nucleoplasm] (Homo sapiens)
WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Homo sapiens)
WHSC1, NSD1, SMYD2, ASH1L [nucleoplasm] (Homo sapiens)
WHSC1 [nucleoplasm] (Homo sapiens)
WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) (Homo sapiens)
WHSC1, NSD1, SMYD2, ASH1L [nucleoplasm] (Homo sapiens)
WHSC1 [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)
WHSC1, WHSC1L1 [nucleoplasm] (Homo sapiens)
WHSC1 [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)
WHSC1, WHSC1L1 [nucleoplasm] (Homo sapiens)
WHSC1 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
ATM phosphorylates WHSC1 (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Homo sapiens)
WHSC1 [nucleoplasm] (Homo sapiens)
WHSC1 binds DNA DSBs (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Homo sapiens)
WHSC1 [nucleoplasm] (Homo sapiens)
WHSC1 [nucleoplasm] (Homo sapiens)
WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Homo sapiens)
WHSC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O96028 NSD2
Gene Names
NSD2, KIAA1090, MMSET, TRX5, WHSC1
Chain
chain:1-1365
Reference Genes
BioGPS Gene:7468 NSD2
COSMIC (genes):NSD2 NSD2
CTD Gene:7468 NSD2
dbSNP Gene:7468 NSD2
ENSEMBL:ENSG00000109685 NSD2
ENSEMBL:ENSG00000109685.19 NSD2
HGNC:12766 NSD2
KEGG Gene (Homo sapiens):7468 NSD2
Monarch:7468 NSD2
NCBI Gene:7468 NSD2
OMIM:602952 NSD2
UCSC:O96028 NSD2
Reference Transcript
RefSeq:XM_011513557.2 NSD2
RefSeq:XM_006713914.3 NSD2
RefSeq:NM_007331.1 NSD2
RefSeq:NM_001042424.2 NSD2
RefSeq:XM_005248005.2 NSD2
RefSeq:XM_005248001.3 NSD2
RefSeq:XM_017008588.1 NSD2
RefSeq:NM_133335.3 NSD2
RefSeq:XM_017008587.1 NSD2
RefSeq:NM_133334.2 NSD2
RefSeq:XM_011513560.2 NSD2
RefSeq:NM_133331.2 NSD2
RefSeq:NM_133330.2 NSD2
Other Identifiers
11726378_a_at
11726379_a_at
11726380_at
11735832_a_at
11736517_a_at
11736518_a_at
11743822_a_at
11744764_s_at
11750010_a_at
11755673_a_at
11763467_x_at
16964050
209052_PM_s_at
209052_s_at
209053_PM_s_at
209053_s_at
209054_PM_s_at
209054_s_at
222777_PM_s_at
222777_s_at
222778_PM_s_at
222778_s_at
223472_PM_at
223472_at
2715077
2715083
2715087
2715088
2715091
2715092
2715093
2715097
2715104
2715106
2715107
2715119
2715123
2715124
2715125
2715128
2715129
2715130
2715131
2715132
2715133
2715134
2715135
2715136
2715137
2715138
2715139
2715140
2715141
2715142
2715143
2715144
2715145
2715146
2715147
2715148
2715149
2715150
2715151
2715152
2715153
2715154
2715155
2715156
2715157
2715158
2715159
2715160
2715161
2715162
2715163
2715164
2715165
2715166
2715167
2715170
2715188
2715189
2715192
2715196
2715197
2715198
2715199
2715200
2715204
38988_at
43329_at
58244_at
60844_at
65059_at
7468
8093539
87565_at
89995_at
A_14_P108035
A_23_P213204
A_23_P307328
A_23_P398530
A_23_P7301
A_24_P2463
A_33_P3380346
A_33_P3423631
GE54735
GE55177
GE63313
GE80227
GO:0000122
GO:0000785
GO:0002376
GO:0003149
GO:0003289
GO:0003290
GO:0003677
GO:0003682
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0006281
GO:0006302
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0008168
GO:0016740
GO:0018024
GO:0032259
GO:0042054
GO:0042799
GO:0043226
GO:0043565
GO:0046872
GO:0046975
GO:0048298
GO:0048856
GO:0060348
GO:0070201
GO:0140096
GO:0140954
GO:0140955
GO:2001032
HMNXSV003043126
HMNXSV003047687
HMNXSV003048416
Hs.110457.0.S1_3p_a_at
Hs.110457.0.S3_3p_a_at
Hs.110457.3.S1_3p_a_at
Hs.110457.3.S2_3p_a_at
ILMN_1663502
ILMN_1705483
ILMN_1766112
ILMN_2296335
ILMN_2334112
PH_hs_0031527
TC04000030.hg
g3249714_3p_at
g4378016_3p_a_at
Participates
as a member of
WHSC1, NSD1, SMYD2, ASH1L [nucleoplasm] (Homo sapiens)
WHSC1, WHSC1L1 [nucleoplasm] (Homo sapiens)
as an input of
WHSC1 binds DNA DSBs (Homo sapiens)
as a component of
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-S102-WHSC1 [nucleoplasm]
Inferred To
WHSC1 [nucleoplasm]
(Canis familiaris)
WHSC1 [nucleoplasm]
(Gallus gallus)
WHSC1 [nucleoplasm]
(Mus musculus)
NSD2 [nucleoplasm]
(Bos taurus)
NSD2 [nucleoplasm]
(Sus scrofa)
fc12c04 [nucleoplasm]
(Danio rerio)
Nsd2 [nucleoplasm]
(Rattus norvegicus)
nsd2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011511859.1
,
XP_016864077.1
,
NP_579889.1
,
NP_579878.1
,
XP_011511862.1
,
NP_015627.1
,
NP_579890.1
,
NP_579877.1
,
XP_005248058.1
,
XP_016864076.1
,
XP_006713977.1
,
NP_001035889.1
,
XP_005248062.1
Guide to Pharmacology - Targets
3220
OpenTargets
ENSG00000109685
HPA
ENSG00000109685-NSD2
GeneCards
O96028
Ensembl
ENSP00000381311
,
ENST00000382888
,
ENST00000420906
,
ENST00000508803
,
ENSP00000423972
,
ENST00000514045
,
ENSP00000372348
,
ENSP00000329167
,
ENSP00000372347
,
ENSP00000372344
,
ENST00000503128
,
ENSP00000399251
,
ENSG00000109685
,
ENST00000382895
,
ENST00000353275
,
ENSP00000425761
,
ENST00000312087
,
ENST00000382891
,
ENST00000382892
,
ENSP00000421681
,
ENSP00000308780
,
ENSP00000372351
,
ENST00000398261
,
ENSP00000504221
,
ENST00000678714
PRO
O96028
Pharos - Targets
O96028
Orphanet
15722
HMDB Protein
HMDBP09022
PDB
5VC8
,
6XCG
,
6UE6
,
7MDN
,
5LSU
,
7VLN
,
7LMT
,
7CRO
,
7E8D
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
0.602
5
UniProt:Q14676 MDC1
6
monoSUMO1-K1840-MDC1 [nucleoplasm]
(R-HSA-4570546)
polySUMO2,3-K1840-MDC1 [nucleoplasm]
(R-HSA-4570473)
MDC1 [nucleoplasm]
(R-HSA-75231)
p-5T-MDC1 [nucleoplasm]
(R-HSA-75236)
K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684074)
SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684061)
0.591
3
UniProt:Q8N7B1 HORM2
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:P0DTD1-PRO_0000449626 REP
0.527
2
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