Reactome | ISG15-EIF2AK2 [cytosol]

ISG15-EIF2AK2 [cytosol]

Stable Identifier

R-HSA-9833968

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ISG15-PKR

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External Reference Information

External Reference

UniProt:P19525 EIF2AK2

Gene Names

EIF2AK2, PKR, PRKR

Chain

initiator methionine:, chain:2-551

Reference Genes

BioGPS Gene:5610 EIF2AK2

COSMIC (genes):EIF2AK2 EIF2AK2

CTD Gene:5610 EIF2AK2

dbSNP Gene:5610 EIF2AK2

ENSEMBL:ENSG00000055332 EIF2AK2

HGNC:9437 EIF2AK2

KEGG:hsa:5610 EIF2AK2

Monarch:5610 EIF2AK2

NCBI Gene:5610 EIF2AK2

OMIM:176871 EIF2AK2

UCSC:P19525 EIF2AK2

Reference Transcript

Other Identifiers

1008_f_at

11730991_a_at

11730992_x_at

16896442

204211_PM_x_at

204211_x_at

213294_PM_at

213294_at

238743_PM_at

238743_at

242898_PM_at

242898_at

2548403

2548404

2548405

2548406

2548407

2548408

2548409

2548410

2548412

2548413

2548414

2548417

2548418

2548420

2548421

2548422

2548423

2548424

2548425

2548426

2548427

2548428

2548429

2548430

2548431

2548433

2548434

2548435

2548436

2548441

38662_at

5610

61940_at

80047_at

8051501

85147_at

A_19_P00804527

A_23_P142750

A_32_P38003

A_33_P3224858

GE61104

GO:0001819

GO:0002376

GO:0003723

GO:0003725

GO:0003824

GO:0004672

GO:0004674

GO:0004694

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0006355

GO:0006412

GO:0006468

GO:0008285

GO:0009615

GO:0016020

GO:0016301

GO:0016740

GO:0017148

GO:0019888

GO:0030968

GO:0032722

GO:0032874

GO:0033689

GO:0034198

GO:0035455

GO:0042802

GO:0043066

GO:0043226

GO:0043410

GO:0045071

GO:0045087

GO:0046777

GO:0048471

GO:0051092

GO:0051607

GO:0098542

GO:0098772

GO:0106310

GO:0140096

GO:0140374

GO:1900225

GO:1901224

GO:1901532

GO:1902033

GO:1902036

HMNXSV003022863

HMNXSV003049578

Hs.169816.0.A1_3p_at

Hs.271866.0.A1_3p_at

Hs.306117.1.A1_3p_at

ILMN_1706502

PH_hs_0025752

TC02001739.hg

TC02004161.hg

U50648_s_at

g4506102_3p_at

Participates

as a component of

ISG15-EIF2AK2 dimer [cytosol] (Homo sapiens)

Other forms of this molecule

EIF2AK2 [cytosol]

p-EIF2AK2 [nucleoplasm]

p-EIF2AK2 [cytosol]

SUMO-EIF2AK2 [cytosol]

Inferred To

EIF2AK2 [cytosol] (Bos taurus)

ISG15-EIF2AK2 [cytosol] (Caenorhabditis elegans)

ISG15-EIF2AK2 [cytosol] (Drosophila melanogaster)

ISG15-EIF2AK2 [cytosol] (Mus musculus)

ISG15-EIF2AK2 [cytosol] (Rattus norvegicus)

ISG15-EIF2AK2 [cytosol] (Sus scrofa)

Modified Residues

Name

crosslinked L-lysine residue at 69

Coordinate

PsiMod Name

crosslinked L-lysine residue

PsiMod Definition

A protein modification that contains an L-lysine residue crosslinked to one or more amino acid residues.

Name

crosslinked L-lysine residue at 159

Coordinate

159

PsiMod Name

crosslinked L-lysine residue

PsiMod Definition

A protein modification that contains an L-lysine residue crosslinked to one or more amino acid residues.

Cross References

RefSeq

XP_011531289.1, NP_001129123.1, NP_001129124.1, NP_002750.1

Guide to Pharmacology - Targets

2016

OpenTargets

ENSG00000055332

ENSEMBL

ENSP00000506024, ENST00000679507, ENSP00000233057, ENST00000681507, ENST00000233057, ENSP00000378559, ENST00000405334, ENST00000647926, ENST00000681463, ENSP00000385014, ENSP00000505138, ENSP00000497534, ENSP00000505772, ENST00000395127

IntEnz

2.7.11.1, 2.7.10.2

HPA

ENSG00000055332-EIF2AK2

ZINC target

P19525

PRO

P19525

Pharos - Targets

P19525

GlyGen

P19525

HMDB Protein

HMDBP08840

PDB

1QU6, 7OBL, 7OBK, 8I9J, 8BI7, 2A1A, 2A19, 8IZN, 6D3L, 6D3K, 3UIU

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.822	8
UniProt:O75569 PRKRA	2	PRKRA [cytosol] (R-HSA-2399897) p-S246,S287-PRKRA [cytosol] (R-HSA-9834791)	0.8	6
UniProt:P05198 EIF2S1	2	EIF2S1 [cytosol] (R-HSA-72510) p-S52-EIF2S1 [cytosol] (R-HSA-381060)	0.783	5
UniProt:Q7L2E3 DHX30			0.708	4
UniProt:Q9UL40 ZN346			0.708	4
UniProt:P27958-PRO_0000037576			0.698	5
UniProt:P27958-PRO_0000037570			0.684	4
UniProt:P20639 PG041			0.667	3
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.623	3
UniProt:Q9NUL3 STAU2			0.623	3
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.623	4
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.623	3
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.615	3
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.602	4
UniProt:Q96P20 NLRP3	2	NLRP3 [cytosol] (R-HSA-561189) K63polyUb-NLRP3 [cytosol] (R-HSA-6783288)	0.602	6
UniProt:P04487 RNB			0.591	3
UniProt:Q27968 DNJC3			0.591	5
UniProt:P19525 EIF2AK2	5	EIF2AK2 [cytosol] (R-HSA-168699) p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) p-EIF2AK2 [cytosol] (R-HSA-9833834) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829)	0.558	2
UniProt:P78563-4 ADARB1			0.556	3
UniProt:O75569-1 PRKRA			0.544	3
UniProt:Q9NZM5 NOP53			0.527	2
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.527	2
UniProt:P51608 MECP2			0.527	2
UniProt:Q8WTT2 NOC3L			0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	2
UniProt:P20248 CCNA2	3	CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.527	2
UniProt:Q14684 RRP1B			0.527	2
UniProt:P55265 ADAR	2	ADAR1 [cytosol] (R-HSA-9835955) ADAR [nucleoplasm] (R-HSA-53939)	0.527	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	2
UniProt:Q96SL4 GPX7	1	GPX7 [endoplasmic reticulum lumen] (R-HSA-3341316)	0.527	2
UniProt:P04798 CYP1A1	1	CYP1A1 [endoplasmic reticulum membrane] (R-HSA-52623)	0.527	2
UniProt:Q9NX58 LYAR			0.527	2
UniProt:Q9BZE4 GTPB4			0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:O75683 SURF6			0.527	2
UniProt:O95793 STAU1			0.527	2
UniProt:Q00577 PURA			0.527	2
UniProt:Q6P2E9 EDC4	1	EDC4 [cytosol] (R-HSA-429963)	0.499	2
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [specific granule lumen] (R-HSA-6799719) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [azurophil granule lumen] (R-HSA-6799709)	0.499	2
UniProt:P56537 IF6			0.499	2
UniProt:Q96C10 DHX58	1	DHX58 [cytosol] (R-HSA-913540)	0.499	2
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.499	2
UniProt:Q15633 TARBP2	2	p-TARBP2 [cytosol] (R-HSA-9835348) TARBP2 [cytosol] (R-HSA-203864)	0.499	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2

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