Reactome | NPB(25-53) [extracellular region]

NPB(25-53) [extracellular region]

Stable Identifier

R-HSA-374790

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Neuropeptide B-29, NPB_HUMAN, NPB

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-53) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-53) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-53) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-53) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-53) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-53) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        GPCR neuropeptide receptor binds neuropeptides B and W (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-53) [extracellular region] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-53) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NG41 NPB

Gene Names

NPB, PPL7, PPNPB

Chain

signal peptide:1-24, peptide:25-53, peptide:25-48, propeptide:56-125

Reference Genes

BioGPS Gene:256933 NPB

COSMIC (genes):NPB NPB

CTD Gene:256933 NPB

dbSNP Gene:256933 NPB

ENSEMBL:ENSG00000183979 NPB

HGNC:30099 NPB

KEGG:hsa:256933 NPB

Monarch:256933 NPB

NCBI Gene:256933 NPB

OMIM:607996 NPB

UCSC:Q8NG41 NPB

Reference Transcript

RefSeq:NM_148896.4 NPB

Other Identifiers

11721350_s_at

11728990_a_at

11741330_a_at

11741331_x_at

11741838_a_at

11754229_x_at

1553663_PM_a_at

1553663_a_at

16838917

16838926

224010_PM_at

224010_at

226414_PM_s_at

226414_s_at

256933

3738295

3738296

3738297

3738298

3738299

3738300

3738301

3738302

3738303

3738304

3738305

3738307

3738308

3738309

3738310

3738311

3738312

3738313

4040523

4040524

4040525

4040526

4040527

4040528

4040529

4040531

4040532

4040533

4040534

4040535

4040536

4040537

4040538

4040539

4040541

45265_at

8010686

8010696

8019687

8019693

A_23_P27147

A_23_P300740

A_33_P3419970

GE62850

GO:0001664

GO:0005515

GO:0005576

GO:0007186

GO:0007218

GO:0007631

HMNXSV003007211

HMNXSV003042468

Hs2.345721.1.S1_3p_a_at

ILMN_1722102

ILMN_1726281

ILMN_1753773

ILMN_1777453

ILMN_2343563

PH_hs_0010810

TC17000939.hg

g12653650_3p_a_at

Participates

as a member of

Neuropeptides B/W [extracellular region] (Homo sapiens)

Other forms of this molecule

NPB(25-48) [extracellular region]

Inferred To

Npb [extracellular region] (Mus musculus)

Npb [extracellular region] (Rattus norvegicus)

NPB [extracellular region] (Bos taurus)

NPB [extracellular region] (Canis familiaris)

NPB [extracellular region] (Sus scrofa)

npb [extracellular region] (Xenopus tropicalis)

NPB(25-53) [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_683694.1

ENSEMBL

ENST00000333383, ENSP00000332766

OpenTargets

ENSG00000183979

HPA

ENSG00000183979-NPB

PRO

Q8NG41

Pharos - Targets

Q8NG41

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108)	0.527	2
UniProt:Q9BTV6 DPH7	1	DPH7 [cytosol] (R-HSA-5358480)	0.527	2
UniProt:P04070 PROC	13	PROC [endoplasmic reticulum lumen] (R-HSA-8956772) p-PROC [endoplasmic reticulum lumen] (R-HSA-8957067) 8xCbxE-3D-PROC(43-197) [extracellular region] (R-HSA-141041) PROC(212-461) [extracellular region] (R-HSA-141048) PROC(200-461) [extracellular region] (R-HSA-141042) PROC(200-211) [extracellular region] (R-HSA-141051) 8xCbxE-3D-PROC(33-197) [endoplasmic reticulum lumen] (R-HSA-159730) PROC(200-461) [endoplasmic reticulum lumen] (R-HSA-159780) 8xCbxE-3D-PROC(33-197) [Golgi lumen] (R-HSA-159747) PROC(200-461) [Golgi lumen] (R-HSA-159827) 3D-PROC(33-197) [endoplasmic reticulum lumen] (R-HSA-159768) PROC(33-42) [Golgi lumen] (R-HSA-159779) 8xCbxE-3D-PROC(43-197) [Golgi lumen] (R-HSA-159756)	0.527	2
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2
UniProt:P62736 ACTA2	1	ACTA2 [cytosol] (R-HSA-445792)	0.527	2