Reactome | IRE1:BiP [endoplasmic reticulum membrane]

IRE1:BiP [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-381202

Type

Complex

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Locations in the PathwayBrowser

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General

The luminal N-teminal domain of IRE1 binds the ATPase domain of BiP, rendering IRE1 inactive.

Participants

components

Participant Of

input

IRE1:BiP dissociates in response to unfolded protein

Inferred To

IRE1:BiP [endoplasmic reticulum membrane] (Caenorhabditis elegans)

IRE1:BiP [endoplasmic reticulum membrane] (Canis familiaris)

IRE1:BiP [endoplasmic reticulum membrane] (Danio rerio)

IRE1:BiP [endoplasmic reticulum membrane] (Dictyostelium discoideum)

IRE1:BiP [endoplasmic reticulum membrane] (Drosophila melanogaster)

IRE1:BiP [endoplasmic reticulum membrane] (Gallus gallus)

IRE1:BiP [endoplasmic reticulum membrane] (Mus musculus)

IRE1:BiP [endoplasmic reticulum membrane] (Rattus norvegicus)

IRE1:BiP [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

IRE1:BiP [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

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