Reactome | DHH(33-?) [extracellular region]

DHH(33-?) [extracellular region]

Stable Identifier

R-HSA-5362781

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Desert hedgehog protein N product, DHH, DHH_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43323 DHH

Gene Names

DHH

Chain

signal peptide:1-22, chain:23-396, chain:23-198

Reference Genes

BioGPS Gene:50846 DHH

COSMIC (genes):DHH DHH

CTD Gene:50846 DHH

dbSNP Gene:50846 DHH

ENSEMBL:ENSG00000139549 DHH

HGNC:2865 DHH

KEGG:hsa:50846 DHH

Monarch:50846 DHH

NCBI Gene:50846 DHH

OMIM:605423 DHH

UCSC:O43323 DHH

Reference Transcript

RefSeq:NM_021044.3 DHH

Other Identifiers

11736826_at

1552730_PM_at

1552730_at

16764232

3453734

3453735

3453759

3453760

3453761

3453762

3453763

3453764

3453768

3453769

3453770

3453771

485_at

50846

7963020

86872_at

A_23_P162314

A_33_P3338740

GE87686

GO:0000139

GO:0001649

GO:0001708

GO:0003824

GO:0005113

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006508

GO:0007224

GO:0007267

GO:0007275

GO:0007286

GO:0008233

GO:0008270

GO:0010468

GO:0016540

GO:0016740

GO:0016787

GO:0022414

GO:0023052

GO:0030154

GO:0030238

GO:0032355

GO:0033327

GO:0042552

GO:0043226

GO:0043627

GO:0045880

GO:0046872

GO:0048856

GO:0050810

GO:0051604

GO:0097264

GO:0140096

GO:0140853

HMNXSV003012179

Hs2.352607.1.S1_3p_at

ILMN_1799996

PH_hs_0017084

TC12001468.hg

TC12002865.hg

U59748_at

Participates

as an output of

Expression of DHH in testis differentiation (Homo sapiens)

as a candidate of

Hh-Npp [extracellular region] (Homo sapiens)

Other forms of this molecule

CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [extracellular region]

CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane]

CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [endoplasmic reticulum lumen]

ub-N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen]

ub-N4glycoAsn-DHH(199-396) [cytosol]

2xHC-DHH(23-396) [endoplasmic reticulum lumen]

N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen]

CHOL-DHH(23-198) [endoplasmic reticulum lumen]

N4glycoAsn-2xHC-DHH(23-396) [endoplasmic reticulum lumen]

Inferred To

DHH [extracellular region] (Canis familiaris)

DHH [extracellular region] (Gallus gallus)

Dhh [extracellular region] (Rattus norvegicus)

DHH(33-?) [extracellular region] (Bos taurus)

DHH(33-?) [extracellular region] (Danio rerio)

DHH(33-?) [extracellular region] (Drosophila melanogaster)

DHH(33-?) [extracellular region] (Mus musculus)

DHH(33-?) [extracellular region] (Sus scrofa)

DHH(33-?) [extracellular region] (Xenopus tropicalis)

Homologues of DHH(33-?) [extracellular region] (Danio rerio)

Cross References

ENSEMBL

ENST00000649637, ENSP00000497483

OpenTargets

ENSG00000139549

HPA

ENSG00000139549-DHH

PRO

O43323

Pharos - Targets

O43323

Orphanet

DHH

PDB

2WG3, 3N1G, 3N1Q, 2WFR, 2WFQ

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96QV1-1 HHIP			0.655	4
UniProt:Q9BWV1 BOC	1	BOC [plasma membrane] (R-HSA-445450)	0.558	2
UniProt:Q4KMG0 CDON	1	CDON [plasma membrane] (R-HSA-197892)	0.558	2
UniProt:Q53HC9 EIPR1			0.527	3
UniProt:Q96I51 RCC1L			0.527	2
UniProt:Q9NWM8 FKBP14 gene	1	FKBP14 [endoplasmic reticulum lumen] (R-HSA-535607)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2
UniProt:P49247 RPIA	2	RPIA [cytosol] (R-HSA-71304) RPIA A61V [cytosol] (R-HSA-5660009)	0.527	2