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ub-N4glycoAsn-DHH(199-396) [cytosol]
Stable Identifier
R-HSA-5362368
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
Hh C-terminal fragments are degraded by the proteasome (Homo sapiens)
ub C-terminal Hh fragments [cytosol] (Homo sapiens)
ub-N4glycoAsn-DHH(199-396) [cytosol] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)
ub C-terminal Hh fragments [cytosol] (Homo sapiens)
ub-N4glycoAsn-DHH(199-396) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43323 DHH
Gene Names
DHH
Chain
signal peptide:1-22, chain:23-396, chain:23-198
Reference Genes
BioGPS Gene:50846 DHH
COSMIC (genes):DHH DHH
CTD Gene:50846 DHH
dbSNP Gene:50846 DHH
ENSEMBL:ENSG00000139549 DHH
HGNC:2865 DHH
KEGG:hsa:50846 DHH
Monarch:50846 DHH
NCBI Gene:50846 DHH
OMIM:605423 DHH
UCSC:O43323 DHH
Reference Transcript
RefSeq:NM_021044.3 DHH
Other Identifiers
11736826_at
1552730_PM_at
1552730_at
16764232
3453734
3453735
3453759
3453760
3453761
3453762
3453763
3453764
3453768
3453769
3453770
3453771
485_at
50846
7963020
86872_at
A_23_P162314
A_33_P3338740
GE87686
GO:0000139
GO:0001649
GO:0001708
GO:0003824
GO:0005113
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006508
GO:0007224
GO:0007267
GO:0007275
GO:0007286
GO:0008233
GO:0008270
GO:0010468
GO:0016540
GO:0016740
GO:0016787
GO:0022414
GO:0023052
GO:0030154
GO:0030238
GO:0032355
GO:0033327
GO:0042552
GO:0043226
GO:0043627
GO:0045880
GO:0046872
GO:0048856
GO:0050810
GO:0051604
GO:0097264
GO:0140096
GO:0140853
HMNXSV003012179
Hs2.352607.1.S1_3p_at
ILMN_1799996
PH_hs_0017084
TC12001468.hg
TC12002865.hg
U59748_at
Participates
as a candidate of
ub C-terminal Hh fragments [cytosol] (Homo sapiens)
Other forms of this molecule
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [extracellular region]
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane]
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [endoplasmic reticulum lumen]
ub-N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen]
2xHC-DHH(23-396) [endoplasmic reticulum lumen]
N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen]
CHOL-DHH(23-198) [endoplasmic reticulum lumen]
N4glycoAsn-2xHC-DHH(23-396) [endoplasmic reticulum lumen]
DHH(33-?) [extracellular region]
Inferred To
Dhh [cytosol]
(Rattus norvegicus)
ub-N4glycoAsn-DHH(199-396) [cytosol]
(Bos taurus)
ub-N4glycoAsn-DHH(199-396) [cytosol]
(Danio rerio)
ub-N4glycoAsn-DHH(199-396) [cytosol]
(Drosophila melanogaster)
ub-N4glycoAsn-DHH(199-396) [cytosol]
(Mus musculus)
ub-N4glycoAsn-DHH(199-396) [cytosol]
(Sus scrofa)
ub-N4glycoAsn-DHH(199-396) [cytosol]
(Xenopus tropicalis)
DHH [cytosol]
(Canis familiaris)
DHH [cytosol]
(Gallus gallus)
Homologues of ub-N4glycoAsn-DHH(199-396) [cytosol]
(Danio rerio)
Modified Residues
Name
N4-glycosyl-L-asparagine at unknown position
PsiMod Name
N4-glycosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.
Name
ubiquitinylated lysine at unknown position
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ENSEMBL
ENST00000649637
,
ENSP00000497483
OpenTargets
ENSG00000139549
HPA
ENSG00000139549-DHH
PRO
O43323
Pharos - Targets
O43323
Orphanet
DHH
PDB
2WG3
,
3N1G
,
3N1Q
,
2WFR
,
2WFQ
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96QV1-1 HHIP
0.655
4
UniProt:Q9BWV1 BOC
1
BOC [plasma membrane]
(R-HSA-445450)
0.558
2
UniProt:Q4KMG0 CDON
1
CDON [plasma membrane]
(R-HSA-197892)
0.558
2
UniProt:Q53HC9 EIPR1
0.527
3
UniProt:Q96I51 RCC1L
0.527
2
UniProt:Q9NWM8 FKBP14 gene
1
FKBP14 [endoplasmic reticulum lumen]
(R-HSA-535607)
0.527
2
UniProt:P11021 HSPA5
6
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
0.527
2
UniProt:P49247 RPIA
2
RPIA [cytosol]
(R-HSA-71304)
RPIA A61V [cytosol]
(R-HSA-5660009)
0.527
2
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