EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol]

Stable Identifier
R-HSA-9713456
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Eukaryotic translation initiation factor 2-alpha kinase 3 ecNumber2.7.11.1/ecNumber, E2AK3_HUMAN
EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
27245569 Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization

Ganesan, S, Hensing, T, Nowak, J, Ou, SH, Allen, J, Ross, JS, Wakelee, H, Schrock, AB, He, J, Zakowski, M, Frampton, GM, Gowen, K, Miller, VA, Menon, S, Chmielecki, J, Ladanyi, M, Molina, JR, Zauderer, M, Klempner, SJ, Peled, N, Firozvi, K, Ali, SM, Stephens, PJ, Fischbach, N, MacMahon, H, Lipson, D, Suh, JH, Sanford, E, Salgia, R, Elvin, JA, Chalmers, Z, Brahmer, JR, Yelensky, R, Kulkarni, A

Oncologist 2016
External Reference Information
External Reference
Gene Names
EIF2AK3, PEK, PERK
Chain
signal peptide:1-29, chain:30-1116
Reference Transcript
Other Identifiers
11722150_a_at
11722151_a_at
11722152_s_at
16900053
218696_PM_at
218696_at
2563662
2563663
2563664
2563666
2563668
2563676
2563678
2563679
2563682
2563683
2563684
2563685
2563686
2563687
2563688
2563689
2563690
2563695
2563703
2563704
2563705
2563706
2563707
2563708
2563709
48034_at
71344_at
8053668
9451
A_23_P135857
GE54955
GO:0000166
GO:0001501
GO:0001503
GO:0001525
GO:0002063
GO:0003824
GO:0004672
GO:0004674
GO:0004694
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0006351
GO:0006355
GO:0006417
GO:0006468
GO:0006919
GO:0006983
GO:0006986
GO:0007029
GO:0010468
GO:0010575
GO:0010628
GO:0010998
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0017148
GO:0018105
GO:0019722
GO:0019899
GO:0019903
GO:0023052
GO:0030154
GO:0030282
GO:0030968
GO:0031018
GO:0031642
GO:0032055
GO:0032057
GO:0034198
GO:0034976
GO:0036211
GO:0036492
GO:0036499
GO:0042149
GO:0042802
GO:0043226
GO:0045182
GO:0045943
GO:0045947
GO:0046777
GO:0048009
GO:0048471
GO:0048856
GO:0050877
GO:0051171
GO:0051879
GO:0060734
GO:0070417
GO:0070887
GO:0080090
GO:0106310
GO:0140096
GO:1900182
GO:1902235
GO:1990737
HMNXSV003004600
ILMN_1724984
PH_hs_0005684
TC02002074.hg
g4758891_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 1058 to 1620 at 145 from UniProt:Q9UM73 ALK
Coordinate
145
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ZINC - Substances
ZINC target
PRO
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04844 RPN2  1 0.643 3
 UniProt:P11021 HSPA5  6 0.589 4
 UniProt:Q8N6Y1 PCD20      0.527 2
 UniProt:Q8IUE0 TF2LY      0.527 2
 UniProt:Q9NY72 SCN3B  1 0.527 2
 UniProt:P13747 HLA-E  7 0.527 2
 UniProt:Q9H1C3 GL8D2      0.527 2
 UniProt:Q07001 CHRND  1 0.527 2
 UniProt:O43505 B4GAT1  1 0.527 3
 UniProt:P01903 HLA-DRA  9 0.527 2
 UniProt:Q9UGM1 CHRNA9  1 0.527 2
 UniProt:P01911 HLA-DRB1  9 0.527 2
 UniProt:Q9NZJ5 EIF2AK3  3 0.524 2
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