EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol]

Stable Identifier
R-HSA-9713456
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Eukaryotic translation initiation factor 2-alpha kinase 3 ecNumber2.7.11.1/ecNumber, E2AK3_HUMAN
EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
27245569 Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization

Ganesan, S, Hensing, T, Nowak, J, Ou, SH, Allen, J, Ross, JS, Wakelee, H, Schrock, AB, He, J, Zakowski, M, Frampton, GM, Gowen, K, Miller, VA, Menon, S, Chmielecki, J, Ladanyi, M, Molina, JR, Zauderer, M, Klempner, SJ, Peled, N, Firozvi, K, Ali, SM, Stephens, PJ, Fischbach, N, MacMahon, H, Lipson, D, Suh, JH, Sanford, E, Salgia, R, Elvin, JA, Chalmers, Z, Brahmer, JR, Yelensky, R, Kulkarni, A

Oncologist 2016
External Reference Information
External Reference
Gene Names
EIF2AK3, PEK, PERK
Chain
signal peptide:1-29, chain:30-1116
Reference Transcript
Other Identifiers
0000580563
11722150_a_at
11722151_a_at
11722152_s_at
16900053
218696_at
2563662
2563663
2563664
2563666
2563668
2563676
2563678
2563679
2563682
2563683
2563684
2563685
2563686
2563687
2563688
2563689
2563690
2563695
2563703
2563704
2563705
2563706
2563707
2563708
2563709
48034_at
71344_at
8053668
9451
A_23_P135857
GE54955
GO:0000166
GO:0001501
GO:0001503
GO:0001525
GO:0002063
GO:0003674
GO:0004672
GO:0004674
GO:0004694
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0006412
GO:0006417
GO:0006464
GO:0006468
GO:0006919
GO:0006950
GO:0006983
GO:0006986
GO:0007029
GO:0007165
GO:0008150
GO:0008219
GO:0009058
GO:0010575
GO:0010628
GO:0010998
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016740
GO:0017148
GO:0018105
GO:0019722
GO:0019899
GO:0019903
GO:0030154
GO:0030176
GO:0030282
GO:0030968
GO:0031018
GO:0031642
GO:0032055
GO:0032057
GO:0034198
GO:0034641
GO:0034976
GO:0036492
GO:0036499
GO:0042149
GO:0042802
GO:0043167
GO:0043226
GO:0045943
GO:0046777
GO:0048009
GO:0048471
GO:0048646
GO:0048856
GO:0050877
GO:0051879
GO:0060734
GO:0070417
GO:0106310
GO:0106311
GO:1900182
GO:1902235
GO:1990737
HMNXSV003004600
ILMN_1724984
PH_hs_0005684
TC02002074.hg
g4758891_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 1058 to 1620 at 145 from UniProt:Q9UM73 ALK
Coordinate
145
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ZINC - Substances
ZINC target
PRO
GlyGen
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
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