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Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5)
Stable Identifier
R-HSA-1791150
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperone genes (Homo sapiens)
Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The BIP (HSPA5) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Literature References
PubMed ID
Title
Journal
Year
14973138
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction
Morrison, L
,
Glembotski, CC
,
Thuerauf, DJ
J Biol Chem
2004
Participants
Input
HSPA5 gene [nucleoplasm]
(Homo sapiens)
Output
HSPA5 [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an event of
ATF6 (ATF6-alpha) activates chaperone genes (Homo sapiens)
This event is regulated
Positively by
Regulator
ATF4 [nucleoplasm]
(Homo sapiens)
Regulator
NF-Y [nucleoplasm]
(Homo sapiens)
Regulator
ATF6(1-380) [nucleoplasm]
(Homo sapiens)
Authored
May, B (2011-10-13)
Reviewed
Gillespie, ME (2008-12-02)
D'Eustachio, P (2008-12-02)
Matthews, L (2008-12-02)
Urano, F (2010-04-30)
Created
May, B (2011-10-21)
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