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CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane]
Stable Identifier
R-HSA-5362420
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Desert hedgehog protein N product, DHH, DHH_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
Hh-Np traffics to the plasma membrane (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (Homo sapiens)
Release of Hh-Np from the secreting cell (Homo sapiens)
Hh-Np binds GPC5 (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (Homo sapiens)
Hh-Np:GPI-GPC5 [plasma membrane] (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (Homo sapiens)
Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Homo sapiens)
Hh-Np:DISP2 [plasma membrane] (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (Homo sapiens)
Hh-Np binds to DISP2 (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (Homo sapiens)
Hh-Np:DISP2 [plasma membrane] (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (Homo sapiens)
Hh-Np is cleaved by ADAM17 to promote ligand shedding (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (Homo sapiens)
NOTUM releases Hh-Np:GPC5 from the plasma membrane (Homo sapiens)
Hh-Np:GPI-GPC5 [plasma membrane] (Homo sapiens)
Hh-Np [plasma membrane] (Homo sapiens)
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43323 DHH
Gene Names
DHH
Chain
signal peptide:1-22, chain:23-396, chain:23-198, chain:199-396
Reference Genes
BioGPS Gene:50846 DHH
COSMIC (genes):DHH DHH
CTD Gene:50846 DHH
dbSNP Gene:50846 DHH
ENSEMBL:ENSG00000139549 DHH
HGNC:2865 DHH
KEGG Gene (Homo sapiens):50846 DHH
Monarch:50846 DHH
NCBI Gene:50846 DHH
OMIM:605423 DHH
UCSC:O43323 DHH
Reference Transcript
RefSeq:NM_021044.3 DHH
Other Identifiers
0004230082
11736826_at
1552730_at
16764232
3453734
3453735
3453759
3453760
3453761
3453762
3453763
3453764
3453768
3453769
3453770
3453771
485_at
50846
7963020
86872_at
A_23_P162314
A_33_P3338740
GE87686
GO:0000003
GO:0001649
GO:0001708
GO:0003674
GO:0005113
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005886
GO:0006508
GO:0006629
GO:0007165
GO:0007224
GO:0007267
GO:0007275
GO:0007286
GO:0008150
GO:0008233
GO:0008270
GO:0009058
GO:0010468
GO:0016020
GO:0016540
GO:0016787
GO:0030154
GO:0030238
GO:0032355
GO:0033327
GO:0042552
GO:0043167
GO:0043627
GO:0046872
GO:0048856
GO:0050810
GO:0051604
Hs2.352607.1.S1_3p_at
ILMN_1799996
ILMN_1890917
PH_hs_0017084
TC12001468.hg
TC12002865.hg
U59748_at
Participant Of
hasCandidate
Hh-Np [plasma membrane]
Other forms of this molecule
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [extracellular region]
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [endoplasmic reticulum lumen]
ub-N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen]
ub-N4glycoAsn-DHH(199-396) [cytosol]
2xHC-DHH(23-396) [endoplasmic reticulum lumen]
N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen]
CHOL-DHH(23-198) [endoplasmic reticulum lumen]
N4glycoAsn-2xHC-DHH(23-396) [endoplasmic reticulum lumen]
DHH(33-?) [extracellular region]
Inferred To
hh [plasma membrane] (Drosophila melanogaster)
shha [plasma membrane] (Danio rerio)
shhb [plasma membrane] (Danio rerio)
Homologues of CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (Danio rerio)
DHH [plasma membrane] (Canis familiaris)
DHH [plasma membrane] (Sus scrofa)
Dhh [plasma membrane] (Mus musculus)
Dhh [plasma membrane] (Rattus norvegicus)
Modified Residues
Name
glycine cholesterol ester at 198
Coordinate
198
PsiMod Name
glycine cholesterol ester [MOD:00314]
PsiMod Definition
A protein modification that effectively converts a glycine residue to glycine cholesterol ester.
Name
N-palmitoyl-L-cysteine at 23
Coordinate
23
PsiMod Name
N-palmitoyl-L-cysteine [MOD:00069]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine.
Cross References
RefSeq
NP_066382.1
OpenTargets
ENSG00000139549
GeneCards
O43323
HPA
ENSG00000139549-DHH
Ensembl
ENST00000649637
,
ENSP00000497483
,
ENSG00000139549
PRO
O43323
Orphanet
15863
PDB
2WFQ
,
3N1G
,
2WG3
,
3N1Q
,
2WFR
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96QV1-1 HHIP
0.655
4
UniProt:Q4KMG0 CDON
1
CDON [plasma membrane]
(R-HSA-197892)
0.558
2
UniProt:Q9BWV1 BOC
1
BOC [plasma membrane]
(R-HSA-445450)
0.558
2
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