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PRSS2(24-247) [extracellular region]
Stable Identifier
R-HSA-1460243
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Trypsin-2, TRY2_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of proMMP9 by proteases (Homo sapiens)
proMMP9 activating proteases [extracellular region] (Homo sapiens)
PRSS2(24-247) [extracellular region] (Homo sapiens)
Initial activation of proMMP1 (Homo sapiens)
proMMP1 initial activators [extracellular region] (Homo sapiens)
PRSS2(24-247) [extracellular region] (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type I degradation by MMP1,2,8,13, PRSS2 (Homo sapiens)
MMP1,2,8,13, PRSS2 [extracellular region] (Homo sapiens)
PRSS2(24-247) [extracellular region] (Homo sapiens)
Collagen type II degradation by MMP1,3,8,13,PRSS2 (Homo sapiens)
MMP1,3,8,13, PRSS2 [extracellular region] (Homo sapiens)
PRSS2(24-247) [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Defensins (Homo sapiens)
Alpha-defensins (Homo sapiens)
pro-HD5 is cleaved by trypsin (Homo sapiens)
Trypsin 2, 3 [extracellular region] (Homo sapiens)
PRSS2(24-247) [extracellular region] (Homo sapiens)
Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Homo sapiens)
Trypsin 2, 3 [extracellular region] (Homo sapiens)
PRSS2(24-247) [extracellular region] (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
PRSS2(24-247) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07478 PRSS2
Gene Names
PRSS2, TRY2, TRYP2
Chain
signal peptide:1-15, propeptide:16-23, chain:24-247
Reference Genes
BioGPS Gene:5645 PRSS2
COSMIC (genes):PRSS2 PRSS2
CTD Gene:5645 PRSS2
dbSNP Gene:5645 PRSS2
ENSEMBL:ENSG00000275896 PRSS2
HGNC:9483 PRSS2
KEGG:hsa:5645 PRSS2
Monarch:5645 PRSS2
NCBI Gene:5645 PRSS2
OMIM:601564 PRSS2
UCSC:P07478 PRSS2
Reference Transcript
RefSeq:NM_002770.3 PRSS2
Other Identifiers
11744079_s_at
11744080_x_at
11760149_a_at
17125794
205402_PM_x_at
205402_x_at
216470_PM_x_at
216470_x_at
3028748
3028753
3028754
3028756
3028757
3028758
3028759
3028760
3028762
3028764
3028765
3028773
3028774
3028776
3028789
3028795
3028807
3028809
3028811
3028819
3028831
3167204
3167210
3167215
3167217
3203657
32796_f_at
5645
8136790
8136801
8136807
A_32_P94444
GE81190
GO:0002376
GO:0003824
GO:0004222
GO:0004252
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0006508
GO:0007586
GO:0008236
GO:0016787
GO:0019730
GO:0022617
GO:0030198
GO:0030307
GO:0030312
GO:0030574
GO:0031012
GO:0035578
GO:0045785
GO:0046872
GO:0098542
GO:0140096
HMNXSV003043278
Hs.303157.10.S1_3p_x_at
ILMN_1750234
U66061_cds3_at
g4506146_3p_x_at
Participates
as a member of
MMP1,2,8,13, PRSS2 [extracellular region] (Homo sapiens)
MMP1,3,8,13, PRSS2 [extracellular region] (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Trypsin 2, 3 [extracellular region] (Homo sapiens)
proMMP9 activating proteases [extracellular region] (Homo sapiens)
proMMP1 initial activators [extracellular region] (Homo sapiens)
Other forms of this molecule
PRSS2 [azurophil granule lumen]
Inferred To
Try5 [extracellular region]
(Rattus norvegicus)
tpsb2 [extracellular region]
(Xenopus tropicalis)
Prss3 [extracellular region]
(Rattus norvegicus)
LOC105945797 [extracellular region]
(Xenopus tropicalis)
LOC121107389 [extracellular region]
(Gallus gallus)
PRSS2 [extracellular region]
(Bos taurus)
PRSS2 [extracellular region]
(Canis familiaris)
prss1 [extracellular region]
(Danio rerio)
prss59.2 [extracellular region]
(Danio rerio)
PRSS2(24-247) [extracellular region]
(Mus musculus)
prss59.1 [extracellular region]
(Danio rerio)
LOC101730988 [extracellular region]
(Xenopus tropicalis)
LOC100485189 [extracellular region]
(Xenopus tropicalis)
LOC107054567 [extracellular region]
(Gallus gallus)
try [extracellular region]
(Sus scrofa)
LOC101732100 [extracellular region]
(Xenopus tropicalis)
Homologues of PRSS2(24-247) [extracellular region]
(Danio rerio)
Homologues of PRSS2(24-247) [extracellular region]
(Gallus gallus)
Homologues of PRSS2(24-247) [extracellular region]
(Rattus norvegicus)
Homologues of PRSS2(24-247) [extracellular region]
(Xenopus tropicalis)
LOC116412104 [extracellular region]
(Xenopus tropicalis)
try10 [extracellular region]
(Xenopus tropicalis)
si:dkey-33m11.8 [extracellular region]
(Danio rerio)
wu:fd14c02 [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_002761.1
Guide to Pharmacology - Targets
2398
ENSEMBL
ENST00000632112
,
ENSP00000487952
,
ENSP00000488338
OpenTargets
ENSG00000275896
ZINC - Substances
TRY2_HUMAN
ZINC target
P07478
PRO
P07478
IntEnz
3.4.21.4
HPA
ENSG00000275896-PRSS2
Pharos - Targets
P07478
Orphanet
PRSS2
ZINC - Predictions - Purchasable
TRY2_HUMAN
HMDB Protein
HMDBP08087
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11021 HSPA5
6
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
0.527
2
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