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ACE2(18-805) [plasma membrane]
Stable Identifier
R-HSA-2022344
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ACE2, Angiotensin-converting enzyme 2, ACE2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Metabolism of Angiotensinogen to Angiotensins (Homo sapiens)
ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Homo sapiens)
ACE2(18-805):Zn2+ dimer [plasma membrane] (Homo sapiens)
ACE2(18-805):Zn2+ [plasma membrane] (Homo sapiens)
ACE2(18-805) [plasma membrane] (Homo sapiens)
ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Homo sapiens)
ACE2(18-805):Zn2+ dimer [plasma membrane] (Homo sapiens)
ACE2(18-805):Zn2+ [plasma membrane] (Homo sapiens)
ACE2(18-805) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BYF1 ACE2
Gene Names
ACE2, UNQ868/PRO1885
Chain
signal peptide:1-17, chain:18-805, chain:18-708
Reference Genes
BioGPS Gene:59272 ACE2
COSMIC (genes):ACE2 ACE2
CTD Gene:59272 ACE2
dbSNP Gene:59272 ACE2
ENSEMBL:ENSG00000130234 ACE2
ENSEMBL_homo_sapiens_GENE:ENSG00000130234.13 ACE2
HGNC:13557 ACE2
KEGG Gene (Homo sapiens):59272 ACE2
Monarch:59272 ACE2
NCBI Gene:59272 ACE2
OMIM:300335 ACE2
UCSC:Q9BYF1 ACE2
Reference Transcript
RefSeq:NM_021804.2 ACE2
Other Identifiers
11725624_at
11725625_s_at
11725626_a_at
17109301
219962_PM_at
219962_at
222257_PM_s_at
222257_s_at
242967_PM_at
242967_at
4000604
4000606
4000607
4000608
4000609
4000611
4000612
4000615
4000616
4000617
4000618
4000619
4000621
4000623
4000624
4000625
4000626
4000627
4000628
4000629
4000630
4000631
4000632
4000633
4000634
4000635
4000636
4000637
4000638
4000640
51620_at
54498_at
59272
8171449
A_23_P252981
GE56434
GO:0001618
GO:0001817
GO:0002003
GO:0003012
GO:0003013
GO:0003051
GO:0003081
GO:0003824
GO:0004175
GO:0004180
GO:0004181
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005783
GO:0005788
GO:0005886
GO:0005929
GO:0006508
GO:0006954
GO:0008233
GO:0008237
GO:0008241
GO:0008270
GO:0009986
GO:0015827
GO:0016020
GO:0016192
GO:0016324
GO:0016787
GO:0019058
GO:0019065
GO:0019229
GO:0022414
GO:0022898
GO:0023052
GO:0030666
GO:0031410
GO:0031526
GO:0034330
GO:0042127
GO:0042802
GO:0042995
GO:0043226
GO:0045121
GO:0046718
GO:0046813
GO:0046872
GO:0048662
GO:0050727
GO:0050877
GO:0050886
GO:0051604
GO:0051957
GO:0055085
GO:0060135
GO:0060452
GO:0061024
GO:0061025
GO:0070062
GO:0070373
GO:0097746
GO:0098670
GO:0140096
GO:1903598
GO:1903779
GO:1905737
GO:2000272
GO:2000379
HMNXSV003041042
Hs.290585.0.A1_3p_s_at
Hs.299056.0.A1_3p_at
ILMN_1667018
PH_hs_0010582
TC0X000878.hg
g11225608_3p_a_at
Participates
as a component of
ACE2(18-805):Zn2+ [plasma membrane] (Homo sapiens)
Other forms of this molecule
ACE2 [endoplasmic reticulum lumen]
glycosylated-ACE2 [endocytic vesicle membrane]
ACE2 [endocytic vesicle membrane]
glycosylated-ACE2 [plasma membrane]
Inferred To
ace2 [plasma membrane]
(Xenopus tropicalis)
ACE2 [plasma membrane]
(Bos taurus)
ACE2 [plasma membrane]
(Canis familiaris)
ACE2 [plasma membrane]
(Sus scrofa)
ACE2(18-805) [plasma membrane]
(Gallus gallus)
ACE2(18-805) [plasma membrane]
(Mus musculus)
ACE2(18-805) [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_068576.1
Guide to Pharmacology - Targets
1614
OpenTargets
ENSG00000130234
ZINC - Substances
ACE2_HUMAN
ZINC target
Q9BYF1
PRO
Q9BYF1
PDB
8I9F
,
7R12
,
7KNI
,
8I92
,
8DV1
,
7V85
,
7SY0
,
7YJ3
,
7W9C
,
8H06
,
7WPA
,
7VXD
,
7A98
,
7TF0
,
6M0J
,
7A96
,
7TN0
,
7YR4
,
7TEW
,
7A94
,
7SY6
,
7XCI
,
8DLK
,
6M18
,
7Y1Z
,
7V88
,
3KBH
,
7EKF
,
7VX5
,
7WBP
,
8DLN
,
7L7F
,
7W98
,
7VXF
,
6LZG
,
6VW1
,
8HRK
,
7EFR
,
6ACK
,
7WGB
,
7YA1
,
7MJN
,
8DLU
,
7WPB
,
6ACG
,
8WRL
,
7EDJ
,
7Y76
,
7V7Z
,
7XO9
,
7XCH
,
8HRU
,
8FXB
,
7UFK
,
7NXC
,
7KJ3
,
8WTJ
,
7ZF7
,
7YEG
,
7KMB
,
3D0H
,
7V87
,
7FDG
,
7SY2
,
7E7E
,
8TOQ
,
7R0Z
,
7YR2
,
7SXZ
,
8I91
,
8TOR
,
7KNB
,
7DDP
,
7XB1
,
7TEZ
,
7EFP
,
8WGW
,
7RPV
,
7V82
,
7P19
,
8TOU
,
7VXA
,
7LO4
,
7T9L
,
7V8A
,
7V61
,
7XBF
,
7Y1Y
,
7KJ4
,
7Y21
,
7P8J
,
7SN0
,
1R4L
,
7VXM
,
8I9E
,
8WRM
,
8ASY
,
7EKC
,
8H5C
,
7DQA
,
7Y9Z
,
7FEM
,
7WHH
,
8DLQ
,
7SXX
,
7DX8
,
7WK4
,
8I9H
,
7WSA
,
7KMZ
,
7Y75
,
7WK5
,
7MJM
,
7T9K
,
7DX6
,
8HRN
,
8JYP
,
7EKH
,
7P55
,
8BFW
,
7DX4
,
8I9B
,
7XWA
,
8VKP
,
7JVO
,
8JJE
,
8DM5
,
7W9B
,
3SCJ
,
7KJ2
,
3SCL
,
7KNH
,
7CT5
,
8S9G
,
7R11
,
6M17
,
7SY1
,
7DRV
,
7VIB
,
7A97
,
7V84
,
8DV2
,
7YR3
,
1R42
,
7VXC
,
7W9I
,
7A92
,
7V81
,
6M1D
,
7A95
,
8DLJ
,
7DWX
,
7YHW
,
7SY5
,
8E7M
,
7Y20
,
7EKG
,
7P8I
,
7VX9
,
7XCP
,
7V89
,
7EKE
,
7WS8
,
7VX4
,
7VXK
,
7XBH
,
7WVP
,
7ZDQ
,
8SPH
,
8IF2
,
8I93
,
8B9P
,
7YA0
,
7YDI
,
7WNM
,
7XO8
,
7WPC
,
7SY8
,
7A91
,
7V80
,
8DLV
,
8SPI
,
8WRH
,
6ACJ
,
7KMS
,
8I9D
,
7SY4
,
8WTD
,
7BH9
,
8BYJ
,
7FDI
,
3D0G
,
7W99
,
8BN1
,
8WGV
,
7V86
,
6CS2
,
3SCI
,
7KNE
,
7SXY
,
7XB0
,
8IOU
,
7WVQ
,
8TOS
,
7XAZ
,
7R10
,
8IOV
,
7V83
,
7U0N
,
7TEX
,
8DF5
,
7DDO
,
7V8B
,
7VXB
,
3D0I
,
7SY7
,
7XID
,
8TOT
,
8WRO
,
2AJF
,
7FDH
,
8DLM
,
7XBG
,
8VKO
,
7WBL
,
7WS9
,
7WBQ
,
8I9G
,
8DLP
,
7L0N
,
8JYN
,
7DX9
,
7XO7
,
8JYO
,
7DX7
,
8HRL
,
7WGC
,
7DX5
,
7WK6
,
7PKI
,
8I9C
,
7DF4
,
7UFL
,
8FXC
,
7R1A
,
3SCK
,
8DM6
,
8AQS
,
7DMU
,
7SY3
ZINC - Investigational
ACE2_HUMAN
HPA
ENSG00000130234-ACE2
GeneCards
Q9BYF1
Ensembl
ENSP00000505992
,
ENSP00000504747
,
ENST00000678073
,
ENSG00000130234
,
ENST00000677282
,
ENST00000427411
,
ENSP00000252519
,
ENSP00000504103
,
ENST00000252519
,
ENSP00000389326
,
ENST00000680121
Pharos - Targets
Q9BYF1
ZINC - Predictions - Purchasable
ACE2_HUMAN
HMDB Protein
HMDBP08177
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.997
242
UniProt:P59594 S
12
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9682868)
N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683594)
trimmed unfolded N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683716)
trimmed N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683608)
trimmed N-glycan-PALM-Spike [endoplasmic reticulum lumen]
(R-COV-9683638)
trimmed N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9683657)
complex N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9683617)
complex N-glycan-PALM-Spike [virion membrane]
(R-COV-9685469)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9686730)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9686693)
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
(R-COV-9686706)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9686724)
0.988
56
UniProt:Q6Q1S2 SPIKE
0.862
9
UniProt:Q9BYF1 ACE2
5
ACE2(18-805) [plasma membrane]
(R-HSA-2022344)
ACE2 [endoplasmic reticulum lumen]
(R-HSA-9683474)
glycosylated-ACE2 [endocytic vesicle membrane]
(R-HSA-9686721)
ACE2 [endocytic vesicle membrane]
(R-HSA-9698958)
glycosylated-ACE2 [plasma membrane]
(R-HSA-9683480)
0.797
5
UniProt:P01042-PRO_0000006688 KNG1
0.73
5
IntAct:EBI-25504301 PEPTIDE-MCA-YVADAPK-DNP
0.73
16
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.722
6
UniProt:P59594-PRO_0000037209 S
0.713
3
UniProt:Q5T2W1 NHRF3
0.713
3
UniProt:P52293 Kpna2
2
Kpna2 [nucleoplasm]
(R-MMU-9619124)
Kpna2 [cytosol]
(R-MMU-9619128)
0.655
4
UniProt:Q695T7 SLC6A19
6
SLC6A19 V295Afs*57 [plasma membrane]
(R-HSA-5659736)
SLC6A19 D173N [plasma membrane]
(R-HSA-5659723)
SLC6A19 I596Hfs*73 [plasma membrane]
(R-HSA-5659728)
SLC6A19 S303L [plasma membrane]
(R-HSA-5659746)
SLC6A19 R240* [plasma membrane]
(R-HSA-5659732)
SLC6A19 [plasma membrane]
(R-HSA-375483)
0.635
4
UniProt:A0A6M3G9R1 A0A6M3G9R1
0.632
4
UniProt:A0A6G6A1M4 A0A6G6A1M4
0.632
4
UniProt:O14745 NHRF1
0.628
7
ChEBI:166834 MLN-4760
0.623
9
UniProt:P30990-PRO_0000019524 NTS
0.623
2
UniProt:P01019-PRO_0000032457 AGT
0.623
2
UniProt:P01019-PRO_0000032458 AGT
0.623
5
ChEBI:82721 DALBAVANCIN
0.618
3
UniProt:Q9Y566 SHANK1
1
SHANK1 [cytosol]
(R-HSA-6794274)
0.609
2
UniProt:Q96L92 SNX27
0.609
2
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.599
4
UniProt:Q9H2X3 CLEC4M
1
CLEC4M [plasma membrane]
(R-HSA-1472862)
0.591
3
UniProt:S A0A6B9WHD3
0.589
2
UniProt:P05556 ITGB1
2
ITGB1 [endosome membrane]
(R-HSA-9611157)
ITGB1 [plasma membrane]
(R-HSA-57596)
0.57
4
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.557
19
ChEBI:16393 SPHINGOSINE
0.544
4
UniProt:Q13685 AAMP
1
AAMP [cytosol]
(R-HSA-9674636)
0.527
2
UniProt:Q5GDB5 Q5GDB5
0.524
2
UniProt:Q14416 GRM2
1
GRM2 [plasma membrane]
(R-HSA-420468)
0.524
2
UniProt:P05067-PRO_0000000092 APP
0.489
3
UniProt:O15393 TMPRSS2
2
TMPRSS2 [extracellular region]
(R-HSA-9681528)
TMPRSS2 [plasma membrane]
(R-HSA-9686707)
0.463
3
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.463
2
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