Reactome | SLC7A8 [plasma membrane]

SLC7A8 [plasma membrane]

Stable Identifier

R-HSA-352156

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Large neutral amino acids transporter small subunit 2, LAT2, L-type amino acid transporter 2

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - Basigin interactions (Homo sapiens)
    - Basigin binds CD98 complex (Homo sapiens)
      - Basigin:CD98hc complex [plasma membrane] (Homo sapiens)
        
        CD98hc complex [plasma membrane] (Homo sapiens)
        
        SLC7A8:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
        
        SLC7A8 [plasma membrane] (Homo sapiens)
      - CD98hc complex [plasma membrane] (Homo sapiens)
        
        SLC7A8:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
        
        SLC7A8 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UHI5 SLC7A8

Gene Names

SLC7A8, LAT2

Chain

chain:1-535

Reference Genes

BioGPS Gene:23428 SLC7A8

COSMIC (genes):SLC7A8 SLC7A8

CTD Gene:23428 SLC7A8

dbSNP Gene:23428 SLC7A8

ENSEMBL:ENSG00000092068 SLC7A8

ENSEMBL_homo_sapiens_GENE:ENSG00000092068.21 SLC7A8

HGNC:11066 SLC7A8

KEGG Gene (Homo sapiens):23428 SLC7A8

Monarch:23428 SLC7A8

NCBI Gene:23428 SLC7A8

OMIM:604235 SLC7A8

UCSC:Q9UHI5 SLC7A8

Reference Transcript

Other Identifiers

11722158_a_at

11722159_a_at

11746410_a_at

11748623_x_at

16790744

202752_PM_x_at

202752_x_at

216092_PM_s_at

216092_s_at

217248_PM_s_at

217248_s_at

23428

3557210

3557211

3557212

3557213

3557214

3557216

3557219

3557222

3557225

3557226

3557227

3557232

3557233

3557238

3557239

3557240

3557249

3557250

3557251

3557259

3557260

3557261

3858920

41271_at

57010_f_at

7977933

A_23_P205489

A_33_P3310301

GE60345

GO:0003013

GO:0003333

GO:0005215

GO:0005515

GO:0005886

GO:0006865

GO:0009925

GO:0015101

GO:0015171

GO:0015175

GO:0015179

GO:0015180

GO:0015187

GO:0015190

GO:0015297

GO:0015349

GO:0015695

GO:0015804

GO:0015807

GO:0015816

GO:0015820

GO:0015827

GO:0015829

GO:0016020

GO:0016323

GO:0016324

GO:0019534

GO:0022857

GO:0031528

GO:0035524

GO:0042605

GO:0046982

GO:0055085

GO:0070327

GO:0089718

GO:0098713

GO:0150104

GO:1901998

GO:1902475

GO:1903801

GO:1904273

HMNXSV003046976

Hs.22891.3.S1_3p_a_at

ILMN_1695093

ILMN_1747397

ILMN_1807894

PH_hs_0002004

TC14000951.hg

g6912669_3p_a_at

Participates

as a component of

SLC7A8:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)

Inferred To

slc7a8 [plasma membrane] (Xenopus tropicalis)

SLC7A8 [plasma membrane] (Bos taurus)

SLC7A8 [plasma membrane] (Canis familiaris)

SLC7A8 [plasma membrane] (Mus musculus)

SLC7A8 [plasma membrane] (Rattus norvegicus)

SLC7A8 [plasma membrane] (Sus scrofa)

JhI-21 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_036376.2, NP_877392.1, NP_001253965.1, NP_001253966.1

Guide to Pharmacology - Targets

897

OpenTargets

ENSG00000092068

HPA

ENSG00000092068-SLC7A8

GeneCards

Q9UHI5

Ensembl

ENSP00000416398, ENST00000529705, ENST00000316902, ENST00000422941, ENSP00000391577, ENST00000453702, ENSP00000434345, ENSG00000092068, ENSP00000320378

PRO

Q9UHI5

Pharos - Targets

Q9UHI5

Orphanet

29103

PDB

7CMI, 7CMH, 7B00, 8A6L

HMDB Protein

HMDBP02392

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.556	3
UniProt:P21964 COMT	2	COMT [plasma membrane] (R-HSA-379386) COMT [cytosol] (R-HSA-175974)	0.556	3
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:O60906 SMPD2	1	SMPD2 [plasma membrane] (R-HSA-194337)	0.556	3