Reactome | NPB(25-48) [extracellular region]

NPB(25-48) [extracellular region]

Stable Identifier

R-HSA-374794

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Neuropeptide B-23, NPB_HUMAN, NPB

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        GPCR neuropeptide receptor binds neuropeptides B and W (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NG41 NPB

Gene Names

NPB, PPL7, PPNPB

Chain

signal peptide:1-24, peptide:25-53, peptide:25-48, propeptide:56-125

Reference Genes

BioGPS Gene:256933 NPB

COSMIC (genes):NPB NPB

CTD Gene:256933 NPB

dbSNP Gene:256933 NPB

ENSEMBL:ENSG00000183979 NPB

HGNC:30099 NPB

KEGG Gene (Homo sapiens):256933 NPB

Monarch:256933 NPB

NCBI Gene:256933 NPB

OMIM:607996 NPB

UCSC:Q8NG41 NPB

Reference Transcript

RefSeq:NM_148896.4 NPB

Other Identifiers

0005340452

11741838_a_at

1553663_PM_a_at

1553663_a_at

16838926

3738308

3738309

3738310

3738312

3738313

4040534

4040535

4040536

4040538

4040539

8010696

8019693

A_23_P300740

A_33_P3419970

GO:0001664

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0007165

GO:0007186

GO:0007218

GO:0007631

GO:0008150

HMNXSV003042468

Hs2.345721.1.S1_3p_a_at

ILMN_1777453

TC17000939.hg

Participates

as a member of

Neuropeptides B/W [extracellular region] (Homo sapiens)

Other forms of this molecule

NPB(25-53) [extracellular region]

Inferred To

Npb [extracellular region] (Mus musculus)

Npb [extracellular region] (Rattus norvegicus)

NPB [extracellular region] (Bos taurus)

NPB [extracellular region] (Canis familiaris)

NPB [extracellular region] (Gallus gallus)

NPB [extracellular region] (Sus scrofa)

npb [extracellular region] (Danio rerio)

npb [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_683694.1

OpenTargets

ENSG00000183979

HPA

ENSG00000183979-NPB

GeneCards

Q8NG41

Ensembl

ENST00000333383, ENSP00000332766, ENSG00000183979

PRO

Q8NG41

Pharos - Targets

Q8NG41