Reactome | NPB(25-48) [extracellular region]

NPB(25-48) [extracellular region]

Stable Identifier

R-HSA-374794

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Neuropeptide B-23, NPB_HUMAN, NPB

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        GPCR neuropeptide receptor binds neuropeptides B and W (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W [extracellular region] (Homo sapiens)
        
        NPB(25-48) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NG41 NPB

Gene Names

NPB, PPL7, PPNPB

Chain

signal peptide:1-24, peptide:25-53, peptide:25-48, propeptide:56-125

Reference Genes

BioGPS Gene:256933 NPB

COSMIC (genes):NPB NPB

CTD Gene:256933 NPB

dbSNP Gene:256933 NPB

ENSEMBL:ENSG00000183979 NPB

ENSEMBL_homo_sapiens_GENE:ENSG00000183979.8 NPB

HGNC:30099 NPB

KEGG Gene (Homo sapiens):256933 NPB

Monarch:256933 NPB

NCBI Gene:256933 NPB

OMIM:607996 NPB

UCSC:Q8NG41 NPB

Reference Transcript

RefSeq:NM_148896.4 NPB

Other Identifiers

11741838_a_at

1553663_PM_a_at

1553663_a_at

16838926

256933

3738308

3738309

3738310

3738312

3738313

4040534

4040535

4040536

4040538

4040539

8010696

8019693

A_23_P300740

A_33_P3419970

GO:0001664

GO:0005515

GO:0005576

GO:0007186

GO:0007218

GO:0007631

GO:0023052

HMNXSV003042468

Hs2.345721.1.S1_3p_a_at

ILMN_1777453

TC17000939.hg

Participates

as a member of

Neuropeptides B/W [extracellular region] (Homo sapiens)

Other forms of this molecule

NPB(25-53) [extracellular region]

Inferred To

Npb [extracellular region] (Mus musculus)

Npb [extracellular region] (Rattus norvegicus)

NPB [extracellular region] (Bos taurus)

NPB [extracellular region] (Canis familiaris)

NPB [extracellular region] (Sus scrofa)

npb [extracellular region] (Xenopus tropicalis)

NPB(25-48) [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_683694.1

OpenTargets

ENSG00000183979

HPA

ENSG00000183979-NPB

GeneCards

Q8NG41

Ensembl

ENSG00000183979, ENSP00000332766, ENST00000333383

PRO

Q8NG41

Pharos - Targets

Q8NG41

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.527	2
UniProt:P62736 ACTA2	1	ACTA2 [cytosol] (R-HSA-445792)	0.527	2
UniProt:P04070 PROC	13	8xCbxE-3D-PROC(43-197) [Golgi lumen] (R-HSA-159756) PROC(33-42) [Golgi lumen] (R-HSA-159779) 3D-PROC(33-197) [endoplasmic reticulum lumen] (R-HSA-159768) PROC(200-461) [Golgi lumen] (R-HSA-159827) 8xCbxE-3D-PROC(33-197) [Golgi lumen] (R-HSA-159747) PROC(200-461) [endoplasmic reticulum lumen] (R-HSA-159780) 8xCbxE-3D-PROC(33-197) [endoplasmic reticulum lumen] (R-HSA-159730) PROC(200-211) [extracellular region] (R-HSA-141051) PROC(212-461) [extracellular region] (R-HSA-141048) 8xCbxE-3D-PROC(43-197) [extracellular region] (R-HSA-141041) PROC [endoplasmic reticulum lumen] (R-HSA-8956772) p-PROC [endoplasmic reticulum lumen] (R-HSA-8957067) PROC(200-461) [extracellular region] (R-HSA-141042)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.527	2
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108)	0.527	2
UniProt:Q9BTV6 DPH7	1	DPH7 [cytosol] (R-HSA-5358480)	0.527	2