Reactome | EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol]

EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9713454

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Eukaryotic translation initiation factor 2-alpha kinase 3 ecNumber2.7.11.1/ecNumber, E2AK3_HUMAN

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        EIF2AK3(30-144)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
        
        EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
27245569	Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization Ganesan, S, Hensing, T, Nowak, J, Ou, SH, Allen, J, Ross, JS, Wakelee, H, Schrock, AB, He, J, Zakowski, M, Frampton, GM, Gowen, K, Miller, VA, Menon, S, Chmielecki, J, Ladanyi, M, Molina, JR, Zauderer, M, Klempner, SJ, Peled, N, Firozvi, K, Ali, SM, Stephens, PJ, Fischbach, N, MacMahon, H, Lipson, D, Suh, JH, Sanford, E, Salgia, R, Elvin, JA, Chalmers, Z, Brahmer, JR, Yelensky, R, Kulkarni, A	Oncologist	2016

External Reference Information

External Reference

UniProt:Q9NZJ5 EIF2AK3

Gene Names

EIF2AK3, PEK, PERK

Chain

signal peptide:1-29, chain:30-1116

Reference Genes

BioGPS Gene:9451 EIF2AK3

COSMIC (genes):EIF2AK3 EIF2AK3

CTD Gene:9451 EIF2AK3

dbSNP Gene:9451 EIF2AK3

ENSEMBL:ENSG00000172071 EIF2AK3

HGNC:3255 EIF2AK3

KEGG:hsa:9451 EIF2AK3

Monarch:9451 EIF2AK3

NCBI Gene:9451 EIF2AK3

OMIM:604032 EIF2AK3

UCSC:Q9NZJ5 EIF2AK3

Reference Transcript

RefSeq:NM_004836.6 EIF2AK3

Other Identifiers

11722150_a_at

11722151_a_at

11722152_s_at

16900053

16900080

218696_PM_at

218696_at

2563660

2563661

2563662

2563663

2563664

2563665

2563666

2563667

2563668

2563669

2563670

2563674

2563675

2563676

2563678

2563679

2563682

2563683

2563684

2563685

2563686

2563687

2563688

2563689

2563690

2563695

2563703

2563704

2563705

2563706

2563707

2563708

2563709

2563726

2563727

2563728

2563729

2563730

2563731

2563732

2563733

2563734

2563735

2563736

48034_at

53491_at

71344_at

8053668

9451

A_21_P0002471

A_21_P0002669

A_21_P0002670

A_23_P135857

GE54955

GE835661

GO:0001501

GO:0001503

GO:0001525

GO:0002063

GO:0003824

GO:0004672

GO:0004674

GO:0004694

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0006355

GO:0006417

GO:0006468

GO:0006919

GO:0006983

GO:0006986

GO:0007029

GO:0010575

GO:0010628

GO:0010998

GO:0016020

GO:0016740

GO:0017148

GO:0018105

GO:0019722

GO:0019899

GO:0019903

GO:0030282

GO:0030968

GO:0031018

GO:0031642

GO:0032055

GO:0032057

GO:0034198

GO:0034976

GO:0036492

GO:0036499

GO:0042149

GO:0042802

GO:0043226

GO:0045943

GO:0045947

GO:0046777

GO:0048009

GO:0048471

GO:0048856

GO:0051879

GO:0060734

GO:0070417

GO:0106310

GO:0140096

GO:1900182

GO:1902235

GO:1990737

HMNXSV003004600

HMNXSV003007031

HMNXSV003009727

HMNXSV003025810

ILMN_1724984

ILMN_1874735

PH_hs_0005684

TC02002074.hg

TC02004394.hg

g4758891_3p_at

p20882

p20883

p20884

Participates

as a component of

EIF2AK3(30-144)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

EIF2AK3 [endoplasmic reticulum membrane]

EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 145 from UniProt:Q9UM73 ALK

Coordinate

145

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1358

Coordinate

1358

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
non-small cell lung carcinoma	DOID:3908	Non-small cell lung cancer (disorder), NSCLC, NSCLC

Cross References

Guide to Pharmacology - Targets

2017

OpenTargets

ENSG00000172071

ENSEMBL

ENSP00000307235, ENST00000303236

ZINC - Substances

E2AK3_HUMAN

ZINC target

Q9NZJ5

PRO

Q9NZJ5

GlyGen

Q9NZJ5

PDB

5SV7, 4X7N, 8EQ9, 4X7O, 4X7H, 4YZS, 4X7J, 4G31, 4M7I, 4X7K, 4G34, 4X7L, 8EQE, 8EQD, 7MF0

HPA

ENSG00000172071-EIF2AK3

Pharos - Targets

Q9NZJ5

Orphanet

EIF2AK3

ZINC - Predictions - Purchasable

E2AK3_HUMAN

HMDB Protein

HMDBP09502

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04844 RPN2	1	RPN2 [endoplasmic reticulum membrane] (R-HSA-264937)	0.643	3
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.589	4
UniProt:P01911 HLA-DRB1	9	HLA class II histocompatibility antigen, DRB1-15 beta chain [plasma membrane] (R-HSA-197644) HLA class II histocompatibility antigen, DRB1-15 beta chain [lysosomal membrane] (R-HSA-2130363) HLA class II histocompatibility antigen, DRB1-15 beta chain [endocytic vesicle membrane] (R-HSA-2130448) HLA class II histocompatibility antigen, DRB1-15 beta chain [clathrin-coated endocytic vesicle membrane] (R-HSA-2130587) HLA class II histocompatibility antigen, DRB1-15 beta chain [transport vesicle membrane] (R-HSA-2130626) HLA class II histocompatibility antigen, DRB1-15 beta chain [trans-Golgi network membrane] (R-HSA-2130737) HLA class II histocompatibility antigen, DRB1-15 beta chain [Golgi membrane] (R-HSA-2214371) HLA class II histocompatibility antigen, DRB1-15 beta chain [ER to Golgi transport vesicle membrane] (R-HSA-2130344) HLA class II histocompatibility antigen, DRB1-15 beta chain [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130328)	0.527	2
UniProt:Q9UGM1 CHRNA9	1	CHRNA9 [plasma membrane] (R-HSA-507827)	0.527	2
UniProt:P01903 HLA-DRA	9	HLA class II histocompatibility antigen, DR alpha chain precursor [plasma membrane] (R-HSA-197588) HLA class II histocompatibility antigen, DR alpha chain precursor [lysosomal membrane] (R-HSA-2130677) HLA class II histocompatibility antigen, DR alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130463) HLA class II histocompatibility antigen, DR alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130442) HLA class II histocompatibility antigen, DR alpha chain precursor [transport vesicle membrane] (R-HSA-2130530) HLA class II histocompatibility antigen, DR alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130586) HLA class II histocompatibility antigen, DR alpha chain precursor [Golgi membrane] (R-HSA-2214390) HLA class II histocompatibility antigen, DR alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130480) HLA class II histocompatibility antigen, DR alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130665)	0.527	2
UniProt:O43505 B4GAT1	1	B4GAT1 [Golgi membrane] (R-HSA-916821)	0.527	3
UniProt:Q07001 CHRND	1	CHRND [plasma membrane] (R-HSA-507847)	0.527	2
UniProt:Q9H1C3 GL8D2			0.527	2
UniProt:P13747 HLA-E	7	HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (R-HSA-197643) HLA class I histocompatibility antigen, E alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983090) HLA class I histocompatibility antigen, E alpha chain precursor [Golgi membrane] (R-HSA-983339) HLA class I histocompatibility antigen, E alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983407) HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane] (R-HSA-1236744) HLA class I histocompatibility antigen, E alpha chain precursor [recycling endosome membrane] (R-HSA-8863974) HLA class I histocompatibility antigen, E alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236793)	0.527	2
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.527	2
UniProt:Q8IUE0 TF2LY			0.527	2
UniProt:Q8N6Y1 PCD20			0.527	2
UniProt:Q9NZJ5 EIF2AK3	3	EIF2AK3 [endoplasmic reticulum membrane] (R-HSA-381046) EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713456) EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713454)	0.524	2