Reactome | O-fuc-ADAMTS18 [endoplasmic reticulum lumen]

O-fuc-ADAMTS18 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-5173143

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

ADAMTS18, A disintegrin and metalloproteinase with thrombospondin motifs 18, ATS18_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TE60 ADAMTS18

Gene Names

ADAMTS18, ADAMTS21

Chain

signal peptide:1-47, propeptide:48-284, chain:285-1221

Reference Genes

BioGPS Gene:170692 ADAMTS18

COSMIC (genes):ADAMTS18 ADAMTS18

CTD Gene:170692 ADAMTS18

dbSNP Gene:170692 ADAMTS18

ENSEMBL:ENSG00000140873 ADAMTS18

HGNC:17110 ADAMTS18

Monarch:170692 ADAMTS18

NCBI Gene:170692 ADAMTS18

OMIM:607512 ADAMTS18

UCSC:Q8TE60 ADAMTS18

Reference Transcript

RefSeq:NM_199355.3 ADAMTS18

Other Identifiers

11729918_at

11729919_a_at

11752704_a_at

11754754_s_at

1553234_PM_at

1553234_at

16828550

170692

230040_PM_at

230040_at

3700161

3700164

3700165

3700166

3700170

3700171

3700174

3700175

3700176

3700177

3700178

3700180

3700181

3700182

3700183

3700187

3700189

3700192

3700193

3700195

3700196

3700197

3700198

3700200

3700201

3700202

3700216

3700220

3700221

3700222

3700223

3700224

42200_at

77629_at

8002941

A_23_P15004

A_32_P34844

GE884997

GO:0001654

GO:0003824

GO:0004222

GO:0005576

GO:0006508

GO:0007229

GO:0008237

GO:0016787

GO:0030198

GO:0030312

GO:0031012

GO:0046872

GO:0048856

GO:0090331

GO:0140096

HMNXSV003020971

Hs.188746.0.A1_3p_at

ILMN_1739872

ILMN_1770152

PH_hs_0022901

TC16001288.hg

Participates

as a candidate of

O-fuc-proteins [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

ADAMTS18 [extracellular region]

ADAMTS18 [endoplasmic reticulum lumen]

glc-fuc-ADAMTS18 [endoplasmic reticulum lumen]

Inferred To

rsc22 [endoplasmic reticulum lumen] (Dictyostelium discoideum)

O-fuc-ADAMTS18 [endoplasmic reticulum lumen] (Bos taurus)

O-fuc-ADAMTS18 [endoplasmic reticulum lumen] (Canis familiaris)

O-fuc-ADAMTS18 [endoplasmic reticulum lumen] (Drosophila melanogaster)

O-fuc-ADAMTS18 [endoplasmic reticulum lumen] (Gallus gallus)

O-fuc-ADAMTS18 [endoplasmic reticulum lumen] (Mus musculus)

O-fuc-ADAMTS18 [endoplasmic reticulum lumen] (Rattus norvegicus)

O-fuc-ADAMTS18 [endoplasmic reticulum lumen] (Sus scrofa)

O-fuc-ADAMTS18 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Modified Residues

Name

O-fucosyl-L-serine at unknown position

PsiMod Name

O-fucosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to an O-fucosylserine.

Cross References

Guide to Pharmacology - Targets

1690

ENSEMBL

ENSP00000282849, ENST00000282849

OpenTargets

ENSG00000140873

HPA

ENSG00000140873-ADAMTS18

PRO

Q8TE60

Pharos - Targets

Q8TE60

GlyGen

Q8TE60

Orphanet

ADAMTS18

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6Y288 B3GLCT	2	B3GALTL G393E [endoplasmic reticulum membrane] (R-HSA-9632239) B3GALTL [endoplasmic reticulum membrane] (R-HSA-5173226)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2
UniProt:P02768 ALB	7	ALB(19-609) [extracellular region] (R-HSA-114609) ALB [platelet alpha granule lumen] (R-HSA-49865) salicyl-ALB [extracellular region] (R-HSA-9750694) acetyl-ALB [extracellular region] (R-HSA-9749660) ALB [extracellular region] (R-HSA-194115) p-ALB [endoplasmic reticulum lumen] (R-HSA-8956930) ALB [endoplasmic reticulum lumen] (R-HSA-8956690)	0.527	2