Reactome | N4GlycoAsn-PalmS WNT7A [extracellular region]

N4GlycoAsn-PalmS WNT7A [extracellular region]

Stable Identifier

R-HSA-3247774

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

N4GlycoAsn-O-palmitoleyl-L-serine-WNT7A, palmitoleyl-N-glycosyl WNT7A, palmitoleoyl-N-glycosyl WNT7A

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00755 WNT7A

Gene Names

WNT7A

Chain

signal peptide:1-31, chain:32-349

Reference Genes

BioGPS Gene:7476 WNT7A

COSMIC (genes):WNT7A WNT7A

CTD Gene:7476 WNT7A

dbSNP Gene:7476 WNT7A

ENSEMBL:ENSG00000154764 WNT7A

ENSEMBL_homo_sapiens_GENE:ENSG00000154764.6 WNT7A

HGNC:12786 WNT7A

KEGG Gene (Homo sapiens):7476 WNT7A

Monarch:7476 WNT7A

NCBI Gene:7476 WNT7A

OMIM:601570 WNT7A

UCSC:O00755 WNT7A

Reference Transcript

RefSeq:NM_004625.3 WNT7A

Other Identifiers

11728161_at

16950989

1886_at

1887_g_at

210248_PM_at

210248_at

2663718

2663719

2663720

2663721

2663722

2663723

2663724

2663725

2663730

2663736

2663741

2663742

2663748

2663749

2663751

36763_at

7476

8085475

A_23_P258410

GE62528

GO:0000578

GO:0001502

GO:0001525

GO:0002062

GO:0005102

GO:0005109

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005788

GO:0005794

GO:0005796

GO:0005886

GO:0006351

GO:0006355

GO:0006915

GO:0007163

GO:0007269

GO:0007275

GO:0007409

GO:0007416

GO:0007548

GO:0008284

GO:0009888

GO:0009953

GO:0009986

GO:0010595

GO:0010628

GO:0012501

GO:0014719

GO:0014834

GO:0016055

GO:0016192

GO:0021707

GO:0021846

GO:0022009

GO:0022414

GO:0023052

GO:0030010

GO:0030154

GO:0030182

GO:0030312

GO:0030326

GO:0030666

GO:0031012

GO:0031133

GO:0031410

GO:0032355

GO:0034330

GO:0035019

GO:0035115

GO:0035116

GO:0035313

GO:0035567

GO:0036465

GO:0042060

GO:0042127

GO:0042733

GO:0043066

GO:0043226

GO:0043627

GO:0045165

GO:0045167

GO:0045893

GO:0045944

GO:0046330

GO:0048018

GO:0048103

GO:0048731

GO:0048856

GO:0048864

GO:0048870

GO:0050678

GO:0050768

GO:0050770

GO:0050808

GO:0050877

GO:0051216

GO:0051247

GO:0051965

GO:0060054

GO:0060065

GO:0060066

GO:0060070

GO:0060071

GO:0060173

GO:0060856

GO:0060997

GO:0061038

GO:0062009

GO:0070062

GO:0070307

GO:0071560

GO:0098685

GO:0098772

GO:0098793

GO:0098978

GO:0099054

GO:0099068

GO:0099175

GO:1904861

GO:1904891

GO:1905386

GO:1905606

GO:2000300

GO:2000463

HMNXSV003004511

ILMN_1778575

PH_hs_0004166

PH_hs_0020727

TC03001192.hg

TC03002816.hg

U53476_at

g5509900_3p_at

Participates

as a member of

WNTs [extracellular region] (Homo sapiens)

Other forms of this molecule

WNT7A [extracellular region]

N4GlycoAsn-PalmS WNT7A [extracellular exosome]

N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane]

WNT7A [endoplasmic reticulum lumen]

N4GlycoAsn-WNT7A [endoplasmic reticulum lumen]

N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen]

N4GlycoAsn-PalmS WNT7A [Golgi lumen]

N4GlycoAsn-PalmS WNT7A [plasma membrane]

Inferred To

Wnt2 [extracellular region] (Drosophila melanogaster)

wntD [extracellular region] (Drosophila melanogaster)

Wnt7a [extracellular region] (Mus musculus)

Wnt7a [extracellular region] (Rattus norvegicus)

WNT7A [extracellular region] (Bos taurus)

WNT7A [extracellular region] (Canis familiaris)

WNT7A [extracellular region] (Gallus gallus)

WNT7A [extracellular region] (Sus scrofa)

wnt7a [extracellular region] (Xenopus tropicalis)

Homologues of N4GlycoAsn-PalmS WNT7A [extracellular region] (Drosophila melanogaster)

Modified Residues

Name

N4-glycosyl-L-asparagine at unknown position

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Name

O-palmitoleyl-L-serine at 206

Coordinate

206

PsiMod Name

O-palmitoleyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine.

Cross References

RefSeq

NP_004616.2

OpenTargets

ENSG00000154764

HPA

ENSG00000154764-WNT7A

GeneCards

O00755

Ensembl

ENST00000285018, ENSG00000154764, ENSP00000285018

PRO

O00755

Pharos - Targets

O00755

Orphanet

15729

PDB

8TZP, 4UZQ, 8TZO

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5W5 WIF1	1	WIF1 [extracellular region] (R-HSA-3769320)	0.623	3
UniProt:Q5T9L3 WLS	5	WLS [extracellular exosome] (R-HSA-3781960) WLS [endocytic vesicle membrane] (R-HSA-3781954) WLS [early endosome membrane] (R-HSA-3247745) WLS [Golgi membrane] (R-HSA-3247747) WLS [plasma membrane] (R-HSA-3247746)	0.564	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:P01130 LDLR	4	LDLR [endolysosome membrane] (R-HSA-6784818) LDLR [endosome membrane] (R-HSA-171127) LDLR [clathrin-coated endocytic vesicle membrane] (R-HSA-171105) LDLR [plasma membrane] (R-HSA-171053)	0.527	2
UniProt:Q6ZUJ8 PIK3AP1	1	p-4Y-PIK3AP1 [plasma membrane] (R-HSA-984814)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.527	2
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.527	2
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.527	2

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