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TSHB [extracellular region]
Stable Identifier
R-HSA-378957
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Thyrotropin subunit beta, TSHB_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Thyroxine biosynthesis (Homo sapiens)
DIT and MIT combine to form triiodothyronine (Homo sapiens)
Thyrotropin [extracellular region] (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
Two DITs combine to form thyroxine (Homo sapiens)
Thyrotropin [extracellular region] (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Peptide hormone biosynthesis (Homo sapiens)
Glycoprotein hormones (Homo sapiens)
Thyrotropin is a heterodimer (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
Thyrotropin [extracellular region] (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
Thyrotropin [extracellular region] (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
Thyrotropin [extracellular region] (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
Thyrotropin [extracellular region] (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
Thyrotropin [extracellular region] (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
Thyrotropin [extracellular region] (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
Thyrotropin [extracellular region] (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Hormone ligand-binding receptors (Homo sapiens)
Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Homo sapiens)
TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
Thyrotropin [extracellular region] (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
Thyrotropin [extracellular region] (Homo sapiens)
TSHB [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01222 TSHB
Gene Names
TSHB
Chain
signal peptide:1-20, chain:21-132, propeptide:133-138
Reference Genes
BioGPS Gene:7252 TSHB
COSMIC (genes):TSHB TSHB
CTD Gene:7252 TSHB
dbSNP Gene:7252 TSHB
ENSEMBL:ENSG00000134200 TSHB
HGNC:12372 TSHB
KEGG:hsa:7252 TSHB
Monarch:7252 TSHB
NCBI Gene:7252 TSHB
OMIM:188540 TSHB
UCSC:P01222 TSHB
Reference Transcript
RefSeq:XM_011542065.2 TSHB
RefSeq:NM_000549.4 TSHB
RefSeq:NM_001277991.1 TSHB
Other Identifiers
11741595_at
16669053
214529_PM_at
214529_at
2353068
2353071
2353072
2353073
2353074
2353075
2353076
33565_at
7252
7904203
A_14_P123161
A_23_P12128
GE60522
GO:0005179
GO:0005576
GO:0005615
GO:0005737
GO:0007186
GO:0007267
GO:0009653
GO:0023052
GO:0033189
GO:0043627
GO:0048018
GO:0051592
GO:0098772
HMNXSV003024694
Hs.53213.0.S1_3p_at
M25164_at
TC01001009.hg
Participates
as an input of
Thyrotropin is a heterodimer (Homo sapiens)
as a component of
Thyrotropin [extracellular region] (Homo sapiens)
Inferred To
tshb [extracellular region]
(Xenopus tropicalis)
Tshb [extracellular region]
(Mus musculus)
Tshb [extracellular region]
(Rattus norvegicus)
TSHB [extracellular region]
(Bos taurus)
TSHB [extracellular region]
(Canis familiaris)
TSHB [extracellular region]
(Gallus gallus)
TSHB [extracellular region]
(Sus scrofa)
Cross References
RefSeq
XP_011540367.1
,
NP_000540.2
,
NP_001264920.1
ENSEMBL
ENSP00000256592
,
ENST00000256592
OpenTargets
ENSG00000134200
HPA
ENSG00000134200-TSHB
PRO
P01222
Pharos - Targets
P01222
Orphanet
TSHB
PDB
7UTZ
,
7T9I
,
7XW5
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BZ76 CNTP3
0.527
2
UniProt:P10321 HLA-C
8
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane]
(R-HSA-1236760)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
(R-HSA-8863915)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane]
(R-HSA-1236799)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-983354)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane]
(R-HSA-983387)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane]
(R-HSA-199595)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [secretory granule membrane]
(R-HSA-6803292)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983044)
0.527
2
UniProt:Q8IUD2 RB6I2
0.527
2
UniProt:Q13509 TUBB3
6
TUBB3 [cytosol]
(R-HSA-190532)
TUBB3 [axonemal microtubule]
(R-HSA-5610436)
Polyglutamyl-TUBB3 [cytosol]
(R-HSA-8867464)
Polyglycyl-TUBB3 [cytosol]
(R-HSA-8867372)
TUBB3 unfolded [cytosol]
(R-HSA-392770)
TUBB3 folding intermediate [cytosol]
(R-HSA-392806)
0.527
2
UniProt:Q9NWM8 FKBP14 gene
1
FKBP14 [endoplasmic reticulum lumen]
(R-HSA-535607)
0.527
2
UniProt:Q9UM22 EPDR1
0.527
2
UniProt:Q9Y576 ASB1
1
ASB1 [cytosol]
(R-HSA-975428)
0.527
2
UniProt:P11021 HSPA5
6
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
0.527
2
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