Reactome | TSHB [extracellular region]

TSHB [extracellular region]

Stable Identifier

R-HSA-378957

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Thyrotropin subunit beta, TSHB_HUMAN

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrotropin [extracellular region] (Homo sapiens)
        
        TSHB [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrotropin [extracellular region] (Homo sapiens)
        
        TSHB [extracellular region] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrotropin [extracellular region] (Homo sapiens)
        
        TSHB [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrotropin [extracellular region] (Homo sapiens)
        
        TSHB [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrotropin [extracellular region] (Homo sapiens)
        
        TSHB [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
        
        Thyrotropin [extracellular region] (Homo sapiens)
        
        TSHB [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Hormone ligand-binding receptors (Homo sapiens)
        
        Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrotropin [extracellular region] (Homo sapiens)
        
        TSHB [extracellular region] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrotropin [extracellular region] (Homo sapiens)
        
        TSHB [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01222 TSHB

Gene Names

TSHB

Chain

signal peptide:1-20, chain:21-132, propeptide:133-138

Reference Genes

BioGPS Gene:7252 TSHB

COSMIC (genes):TSHB TSHB

CTD Gene:7252 TSHB

dbSNP Gene:7252 TSHB

ENSEMBL:ENSG00000134200 TSHB

ENSEMBL:ENSG00000134200.4 TSHB

HGNC:12372 TSHB

KEGG Gene (Homo sapiens):7252 TSHB

Monarch:7252 TSHB

NCBI Gene:7252 TSHB

OMIM:188540 TSHB

UCSC:P01222 TSHB

Reference Transcript

Other Identifiers

11741595_at

16669053

214529_PM_at

214529_at

2353068

2353071

2353072

2353073

2353074

2353075

2353076

33565_at

7252

7904203

A_14_P123161

A_23_P12128

GE60522

GO:0005102

GO:0005179

GO:0005576

GO:0005615

GO:0005737

GO:0007186

GO:0007267

GO:0009653

GO:0023052

GO:0033189

GO:0043627

GO:0048018

GO:0048856

GO:0051592

GO:0051716

GO:0098772

HMNXSV003024694

Hs.53213.0.S1_3p_at

M25164_at

TC01001009.hg

Participates

as an input of

Thyrotropin is a heterodimer (Homo sapiens)

as a component of

Thyrotropin [extracellular region] (Homo sapiens)

Inferred To

Homologues of TSHB [extracellular region] (Sus scrofa)

tshb [extracellular region] (Xenopus tropicalis)

Tshb [extracellular region] (Mus musculus)

Tshb [extracellular region] (Rattus norvegicus)

TSHB [extracellular region] (Bos taurus)

TSHB [extracellular region] (Canis familiaris)

TSHB [extracellular region] (Danio rerio)

TSHB [extracellular region] (Gallus gallus)

TSHB [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_000540.2, NP_001264920.1, XP_011540367.1

OpenTargets

ENSG00000134200

HPA

ENSG00000134200-TSHB

GeneCards

P01222

Ensembl

ENSG00000134200, ENST00000256592, ENSP00000256592

PRO

P01222

Pharos - Targets

P01222

Orphanet

17670

PDB

7UTZ, 7T9I, 7XW5