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EPHA8 [plasma membrane]
Stable Identifier
R-HSA-2682321
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ephrin type-A receptor 8 ecNumber2.7.10.1/ecNumber, EPHA8_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH receptors autophosphorylate (Homo sapiens)
EPH-ephrin oligomers [plasma membrane] (Homo sapiens)
EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EPHAs [plasma membrane] (Homo sapiens)
EPHA8 [plasma membrane] (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
ADAM10 cleaves EFNAs (Homo sapiens)
EPHAs [plasma membrane] (Homo sapiens)
EPHA8 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs:ADAM10 [plasma membrane] (Homo sapiens)
EPHAs [plasma membrane] (Homo sapiens)
EPHA8 [plasma membrane] (Homo sapiens)
EPH:EFN dimers tetramerise (Homo sapiens)
EPH-EFN dimers [plasma membrane] (Homo sapiens)
EPHA:EFNA dimers [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EPHAs [plasma membrane] (Homo sapiens)
EPHA8 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EPHAs [plasma membrane] (Homo sapiens)
EPHA8 [plasma membrane] (Homo sapiens)
EPH:EFN tetramers oligomerise (Homo sapiens)
EPH-EFN dimers [plasma membrane] (Homo sapiens)
EPHA:EFNA dimers [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EPHAs [plasma membrane] (Homo sapiens)
EPHA8 [plasma membrane] (Homo sapiens)
EPH-ephrin oligomers [plasma membrane] (Homo sapiens)
EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EPHAs [plasma membrane] (Homo sapiens)
EPHA8 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EPHAs [plasma membrane] (Homo sapiens)
EPHA8 [plasma membrane] (Homo sapiens)
EPHAs bind EFNAs (Homo sapiens)
EPHAs [plasma membrane] (Homo sapiens)
EPHA8 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs [plasma membrane] (Homo sapiens)
EPHAs [plasma membrane] (Homo sapiens)
EPHA8 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29322 EPHA8
Gene Names
EPHA8, EEK, HEK3, KIAA1459
Chain
signal peptide:1-27, chain:28-1005
Reference Genes
BioGPS Gene:2046 EPHA8
COSMIC (genes):EPHA8 EPHA8
CTD Gene:2046 EPHA8
dbSNP Gene:2046 EPHA8
ENSEMBL:ENSG00000070886 EPHA8
HGNC:3391 EPHA8
KEGG:hsa:2046 EPHA8
Monarch:2046 EPHA8
NCBI Gene:2046 EPHA8
OMIM:176945 EPHA8
UCSC:P29322 EPHA8
Reference Transcript
RefSeq:NM_020526.4 EPHA8
RefSeq:NM_001006943.2 EPHA8
Other Identifiers
11731250_a_at
11731251_at
11734494_at
1554069_PM_at
1554069_at
16660555
2046
231796_PM_at
231796_at
2324825
2324826
2324829
2324830
2324833
2324835
2324836
2324837
2324838
2324839
2324840
2324841
2324842
2324843
2324844
2324845
2324846
2324848
2324850
2324851
2324852
2324853
52688_at
7898773
A_14_P104676
A_23_P318464
A_24_P419239
A_33_P3408852
GE85538
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005003
GO:0005004
GO:0005005
GO:0005515
GO:0005524
GO:0005768
GO:0005886
GO:0006468
GO:0006929
GO:0007155
GO:0007169
GO:0007399
GO:0007411
GO:0016020
GO:0016322
GO:0016740
GO:0019838
GO:0030155
GO:0030425
GO:0031175
GO:0031410
GO:0031901
GO:0033628
GO:0042995
GO:0043005
GO:0043226
GO:0043410
GO:0048013
GO:0048856
GO:0048870
GO:0051897
GO:0060089
GO:0071372
GO:0140096
HMNXSV003041997
Hs.283613.0.S2_3p_at
Hs2.283613.2.A1_3p_at
Hs2.283613.2.A1_3p_s_at
ILMN_1756989
ILMN_2340599
PH_hs_0014651
TC01000284.hg
Participates
as a member of
EPHAs [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y610,Y616-EPHA8 [plasma membrane]
Inferred To
EPHA8 [plasma membrane]
(Canis familiaris)
EPHA8 [plasma membrane]
(Gallus gallus)
EPHA8 [plasma membrane]
(Mus musculus)
EPHA8 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001006944.1
,
NP_065387.1
ZINC - World Drugs
EPHA8_HUMAN
Guide to Pharmacology - Targets
1828
ENSEMBL
ENSP00000166244
,
ENSP00000363775
,
ENST00000166244
,
ENST00000374644
OpenTargets
ENSG00000070886
ZINC - FDA approved
EPHA8_HUMAN
ZINC - Substances
EPHA8_HUMAN
ZINC - Biogenic
EPHA8_HUMAN
ZINC target
P29322
PRO
P29322
GlyGen
P29322
PDB
1X5L
,
1UCV
,
3KUL
ZINC - Investigational
EPHA8_HUMAN
IntEnz
2.7.10.1
HPA
ENSG00000070886-EPHA8
Pharos - Targets
P29322
ZINC - Predictions - Purchasable
EPHA8_HUMAN
HMDB Protein
HMDBP09444
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11021 HSPA5
6
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
0.569
3
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