Reactome | UBE2V1 [cytosol]

UBE2V1 [cytosol]

Stable Identifier

R-HSA-205753

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
        
        Activated TAK complexes [cytosol] (Homo sapiens)
        
        hp-IRAK1:K63polyUboligo-TRAF6:Activated TAK1 complex [cytosol] (Homo sapiens)
        
        hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 [cytosol] (Homo sapiens)
        
        UBE2N:UBE2V1 [cytosol] (Homo sapiens)
        
        UBE2V1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13404 UBE2V1

Gene Names

UBE2V1, CROC1, UBE2V, UEV1, P/OKcl.19

Chain

initiator methionine:1, chain:2-147

Reference Genes

BioGPS Gene:7335 UBE2V1

COSMIC - genes:UBE2V1 UBE2V1

CTD Gene:7335 UBE2V1

dbSNP Gene:7335 UBE2V1

ENSEMBL:ENSG00000244687 UBE2V1

HGNC:12494 UBE2V1

KEGG:hsa:387522 UBE2V1

KEGG:hsa:7335 UBE2V1

Monarch:7335 UBE2V1

NCBI Gene:7335 UBE2V1

OMIM:602995 UBE2V1

UCSC:Q13404 UBE2V1

Reference Transcript

Participates

as a component of

as a candidate of

E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)

Inferred To

UBE2V1 [cytosol] (Bos taurus)

UBE2V1 [cytosol] (Canis familiaris)

UBE2V1 [cytosol] (Plasmodium falciparum)

UBE2V1 [cytosol] (Rattus norvegicus)

UBE2V1 [cytosol] (Sus scrofa)

Uev1A [cytosol] (Drosophila melanogaster)

mms2 [cytosol] (Schizosaccharomyces pombe)

MMS2 [cytosol] (Saccharomyces cerevisiae)

Ube2v1 [cytosol] (Mus musculus)

uev-1 [cytosol] (Caenorhabditis elegans)

ube2v1 [cytosol] (Danio rerio)

ube2v [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_068823.2, NP_954595.1, NP_954673.2, NP_001244325.1, NP_001244323.1, NP_071887.1, NP_001027459.1, NP_001244322.1

OpenTargets

ENSG00000244687

ENSEMBL

ENSP00000360739, ENSP00000407770, ENST00000371674, ENST00000340309, ENSP00000360742, ENSP00000360720, ENSP00000340305, ENST00000371677, ENST00000371657, ENSG00000244687, ENST00000415862

HPA

ENSG00000244687-UBE2V1

GeneCards

UBE2V1

PRO

Q13404

Pharos - Targets

Q13404

GlyGen

Q13404

PDB

2HLW, 6D6I, 2C2V, 2A4D

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61088 UBE2N	5	UBE2N [cytosol] (R-HSA-206072) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) UBE2N [nucleoplasm] (R-HSA-5682541) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013)	0.91	22
UniProt:P98170 XIAP	4	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366) XIAP [cytosol] (R-HSA-114444)	0.667	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.656	3
UniProt:Q6ZNA4 RNF111	2	RNF111 [nucleoplasm] (R-HSA-2186765) RNF111 [cytosol] (R-HSA-975981)	0.592	2
UniProt:P11021 HSPA5	7	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [plasma membrane] (R-HSA-9922467)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3

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