Reactome | ERBB2 I767M [plasma membrane]

ERBB2 I767M [plasma membrane]

Stable Identifier

R-HSA-9646737

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

HER2 I767M, ERBB2 Ile767Met, HER2 Ile767Met

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ERBB2 in Cancer (Homo sapiens)
    - Drug resistance in ERBB2 KD mutants (Homo sapiens)
      - Resistance of ERBB2 KD mutants to lapatinib (Homo sapiens)
        
        Resistant ERBB2 KD mutants do not bind lapatinib (Homo sapiens)
        
        ERBB2 KD mutants (lapatinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (lapatinib resistant) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
      - Resistance of ERBB2 KD mutants to trastuzumab (Homo sapiens)
        
        Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)
        
        ERBB2 KD mutants (trastuzumab resistant):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
    - Signaling by ERBB2 KD Mutants (Homo sapiens)
      - ERBB2 KD mutants bind TKIs (Homo sapiens)
        
        ERBB2 KD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (TKI sensitive) [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (neratinib) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (osimertinib) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (sapitinib) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:TKIs [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:neratinib [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (neratinib) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:osimertinib [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (osimertinib) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:sapitinib [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (sapitinib) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
      - ERBB2 KD mutants heterodimerize (Homo sapiens)
        
        ERBB2 KD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
        
        Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
      - ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
        
        ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:TKIs [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:neratinib [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (neratinib) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:osimertinib [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (osimertinib) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:sapitinib [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (sapitinib) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)
        
        Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] (Homo sapiens)
        
        ERBB2 I767M [plasma membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
25994018	Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification Geyer, FC, Wai, P, Wilkerson, PM, Penault-Llorca, F, Arnould, L, Ng, CK, Gauthier, A, Norton, L, Reis-Filho, JS, Cowell, CF, Weigelt, B, Martelotto, LG, Sastre-Garau, X, Wen, HC, Giard, S, Lacroix-Triki, M, Cottu, PH, Lim, RS, Natrajan, R, Bromberg, SE, Piscuoglio, S, Rodrigues, DN, Vincent-Salomon, A	Genome Biol.	2015
23220880	Activating HER2 mutations in HER2 gene amplification negative breast cancer Bose, R, Shen, W, Aronson, AB, Goel, N, Koboldt, DC, Li, S, Searleman, AC, Ma, CX, Ellis, MJ, Shen, D, Ding, L, Monsey, J, Mardis, ER, Kavuri, SM	Cancer Discov	2013

External Reference Information

External Reference

UniProt:P04626 ERBB2

Gene Names

ERBB2, HER2, MLN19, NEU, NGL

Chain

signal peptide:1-22, chain:23-1255

Reference Genes

BioGPS Gene:2064 ERBB2

COSMIC (genes):ERBB2 ERBB2

CTD Gene:2064 ERBB2

dbSNP Gene:2064 ERBB2

ENSEMBL:ENSG00000141736 ERBB2

ENSEMBL_homo_sapiens_GENE:ENSG00000141736.14 ERBB2

HGNC:3430 ERBB2

KEGG Gene (Homo sapiens):2064 ERBB2

Monarch:2064 ERBB2

NCBI Gene:2064 ERBB2

OMIM:164870 ERBB2

UCSC:P04626 ERBB2

Reference Transcript

Other Identifiers

11736472_a_at

11750611_a_at

11751416_a_at

11755005_a_at

11762165_x_at

16833839

1802_s_at

1901_s_at

2064

210930_3p_s_at

210930_PM_s_at

210930_s_at

216836_PM_s_at

216836_s_at

33218_at

3720403

3720404

3720405

3720406

3720407

3720408

3720410

3720411

3720412

3720413

3720417

3720420

3720422

3720423

3720425

3720427

3720428

3720431

3720432

3720433

3720434

3720436

3720438

3720440

3720442

3720444

3720446

3720447

3720449

3720452

3720454

3720455

3720457

3720458

3720460

3720461

3720462

3720463

3720464

3720465

3720466

3720467

3720468

3720469

3720470

3720471

8006906

A_14_P101724

A_14_P126019

A_23_P89249

A_24_P284420

A_33_P3292596

GE57810

GO:0000166

GO:0001042

GO:0001934

GO:0002116

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0004888

GO:0005102

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006886

GO:0007155

GO:0007165

GO:0007166

GO:0007167

GO:0007169

GO:0007399

GO:0007422

GO:0007507

GO:0007528

GO:0008045

GO:0008284

GO:0009925

GO:0010008

GO:0010628

GO:0012501

GO:0014044

GO:0015026

GO:0016020

GO:0016301

GO:0016310

GO:0016323

GO:0016324

GO:0016740

GO:0018108

GO:0019838

GO:0022008

GO:0023052

GO:0030154

GO:0030182

GO:0030307

GO:0030971

GO:0031410

GO:0031594

GO:0032587

GO:0032886

GO:0033080

GO:0033088

GO:0034330

GO:0035025

GO:0035556

GO:0036211

GO:0038127

GO:0038133

GO:0038134

GO:0038135

GO:0038143

GO:0042060

GO:0042127

GO:0042552

GO:0042734

GO:0042802

GO:0042995

GO:0043066

GO:0043125

GO:0043209

GO:0043226

GO:0043235

GO:0043406

GO:0043410

GO:0043491

GO:0045727

GO:0045765

GO:0045785

GO:0045943

GO:0046982

GO:0048471

GO:0048709

GO:0048856

GO:0050679

GO:0060089

GO:0070372

GO:0071363

GO:0071364

GO:0071526

GO:0090314

GO:0098590

GO:0099645

GO:0140096

HMNXSV003015366

HMNXSV003026104

HMNXSV003035749

Hs.323910.2.A1_3p_a_at

ILMN_1717902

ILMN_1728761

ILMN_2352131

PH_hs_0021933

TC17000480.hg

X03363_s_at

g10181232_3p_a_at

Participates

as a member of

as a candidate of

Other forms of this molecule

ERBB2 G309E [plasma membrane]

ERBB2 G309A [plasma membrane]

ERBB2 S310F [plasma membrane]

ERBB2 S310Y [plasma membrane]

p-6Y-ERBB2 G309A [plasma membrane]

p-6Y-ERBB2 G309E [plasma membrane]

p-6Y-ERBB2 S310F [plasma membrane]

p-6Y-ERBB2 S310Y [plasma membrane]

p-Y-ERBB2 L755P [plasma membrane]

p-Y-ERBB2 I767M [plasma membrane]

p-Y-ERBB2 T798I [plasma membrane]

p-Y-ERBB2 Y772_A775dup [plasma membrane]

p-Y-ERBB2 T862A [plasma membrane]

p-Y-ERBB2 T798M [plasma membrane]

p-Y-ERBB2 H878Y [plasma membrane]

p-Y-ERBB2 V777L [plasma membrane]

p-Y-ERBB2 L755S [plasma membrane]

p-Y-ERBB2 V777E [plasma membrane]

p-Y-ERBB2 V777M [plasma membrane]

p-Y-ERBB2 L755M [plasma membrane]

p-Y-ERBB2 L755W [plasma membrane]

p-Y-ERBB2 T733I [plasma membrane]

p-Y-ERBB2 H878R [plasma membrane]

p-Y-ERBB2 L869R [plasma membrane]

p-Y-ERBB2 G776S [plasma membrane]

p-Y-ERBB2 L869Q [plasma membrane]

p-Y-ERBB2 G776L [plasma membrane]

p-Y-ERBB2 G776V [plasma membrane]

p-Y-ERBB2 G776C [plasma membrane]

ERBB2 D769Y [plasma membrane]

ERBB2 L755P [plasma membrane]

ERBB2 V842I [plasma membrane]

ERBB2 H878Y [plasma membrane]

ERBB2 T798M [plasma membrane]

ERBB2 D769H [plasma membrane]

ERBB2 T862A [plasma membrane]

ERBB2 Y772_A775dup [plasma membrane]

ERBB2 L755S [plasma membrane]

ERBB2 V777L [plasma membrane]

ERBB2 D769N [plasma membrane]

ERBB2 T733I [plasma membrane]

ERBB2 V777M [plasma membrane]

ERBB2 V777E [plasma membrane]

ERBB2 L755W [plasma membrane]

ERBB2 L755M [plasma membrane]

ERBB2 H878R [plasma membrane]

ERBB2 V842E [plasma membrane]

ERBB2 T798I [plasma membrane]

ERBB2 R896C [plasma membrane]

ERBB2 G778_P780dup [plasma membrane]

ERBB2 R896H [plasma membrane]

ERBB2 G776S [plasma membrane]

ERBB2 L869R [plasma membrane]

ERBB2 L869Q [plasma membrane]

ERBB2 G776C [plasma membrane]

ERBB2 G776L [plasma membrane]

ERBB2 G776V [plasma membrane]

p-6Y-ERBB2 Y772_A775dup [plasma membrane]

p-6Y-ERBB2 V777L [plasma membrane]

p-6Y-ERBB2 H878Y [plasma membrane]

ERBB2 L755_T759del [plasma membrane]

p-6Y-ERBB2 R896C [plasma membrane]

p-6Y-ERBB2 V842I [plasma membrane]

p-6Y-ERBB2 I767M [plasma membrane]

p-6Y-ERBB2 T862A [plasma membrane]

p-6Y-ERBB2 D769H [plasma membrane]

p-6Y-ERBB2 T798I [plasma membrane]

p-6Y-ERBB2 L755P [plasma membrane]

p-6Y-ERBB2 G778_P780dup [plasma membrane]

p-6Y-ERBB2 L755S [plasma membrane]

p-6Y-ERBB2 T798M [plasma membrane]

p-6Y-ERBB2 D769Y [plasma membrane]

p-6Y-ERBB2 V777E [plasma membrane]

p-6Y-ERBB2 T733I [plasma membrane]

p-6Y-ERBB2 L755M [plasma membrane]

p-6Y-ERBB2 V777M [plasma membrane]

p-6Y-ERBB2 V842E [plasma membrane]

p-6Y-ERBB2 D769N [plasma membrane]

p-6Y-ERBB2 R896H [plasma membrane]

p-6Y-ERBB2 L755W [plasma membrane]

p-6Y-ERBB2 H878R [plasma membrane]

p-6Y-ERBB2 E693K [plasma membrane]

p-6Y-ERBB2 R677L [plasma membrane]

p-6Y-ERBB2 Q709L [plasma membrane]

p-6Y-ERBB2 G660D [plasma membrane]

p-6Y-ERBB2 G660R [plasma membrane]

p-6Y-ERBB2 V659K [plasma membrane]

p-6Y-ERBB2 V659E [plasma membrane]

ERBB2 R678Q [plasma membrane]

ERBB2 S653C [plasma membrane]

ERBB2 R677L [plasma membrane]

ERBB2 G660R [plasma membrane]

ERBB2 V659E [plasma membrane]

ERBB2 G660D [plasma membrane]

ERBB2 V659K [plasma membrane]

ERBB2 Q709L [plasma membrane]

ERBB2 E693K [plasma membrane]

p-6Y-ERBB2 R678Q [plasma membrane]

p-6Y-ERBB2 S653C [plasma membrane]

p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]

ERBB2 [plasma membrane]

p-Y877-ERBB2 [plasma membrane]

p-Y-ERBB2 [plasma membrane]

p-Y,Y877-ERBB2 [plasma membrane]

p-6Y-ERBB2 [plasma membrane]

p-7Y-ERBB2 [plasma membrane]

p-6Y,Y1112-ERBB2 [plasma membrane]

p-7Y,Y1112-ERBB2 [plasma membrane]

Modified Residues

Name

L-isoleucine 767 replaced with L-methionine

Coordinate

767

PsiMod

L-methionine residue [MOD:00022]

A protein modification that effectively converts a source amino acid residue to L-methionine.

L-isoleucine removal [MOD:01640]

A protein modification that effectively removes or replaces an L-isoleucine.

Disease

Name	Identifier	Synonyms
esophagus squamous cell carcinoma	DOID:3748	SCC of esophagus, squamous cell carcinoma of esophagus
bladder carcinoma	DOID:4007	carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
ovarian cancer	DOID:2394	ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
nasopharynx carcinoma	DOID:9261	malignant neoplasm of nasopharynx, malignant neoplasm of anterior wall of nasopharynx, malignant neoplasm of lateral wall of nasopharynx, malignant tumor of lateral wall of nasopharynx, Nasopharyngeal carcinoma, carcinoma of nasopharynx, malignant tumor of posterior wall of nasopharynx, malignant Nasopharyngeal tumor, malignant neoplasm of posterior wall of nasopharynx, malignant neoplasm of nasopharyngeal wall, malignant neoplasm of other specified sites of nasopharynx, primary malignant neoplasm of anterior wall of nasopharynx, malignant tumor of anterior wall of nasopharynx, malignant neoplasm of roof of nasopharynx, malignant neoplasm of superior wall of nasopharynx, nasopharynx cancer
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
skin melanoma	DOID:8923	malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma
breast cancer	DOID:1612	malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
salivary gland cancer	DOID:8850	malignant neoplasm of salivary gland NOS, malignant tumor of the Salivary gland, malignant neoplasm of salivary gland duct, malignant neoplasm of major salivary gland, NOS, malignant neoplasm of major salivary gland NOS (disorder), malignant neoplasm of major salivary gland NOS, malignant neoplasm of salivary gland, malignant neoplasm of salivary gland, unspecified, malignant tumor of salivary gland (disorder), malignant tumor of major salivary gland (disorder), malignant tumor of the Major Salivary gland, malignant neoplasm of major salivary gland, malignant neoplasm of other major salivary glands (disorder), malignant neoplasm of other major salivary glands
large intestine cancer	DOID:5672	malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS

Cross References

RefSeq

NP_001005862.1, NP_001276865.1, NP_001276867.1, NP_004439.2

ZINC - World Drugs

ERBB2_HUMAN

Guide to Pharmacology - Targets

2019

OpenTargets

ENSG00000141736

ZINC - FDA approved

ERBB2_HUMAN

ZINC - Substances

ERBB2_HUMAN

ZINC - Biogenic

ERBB2_HUMAN

ZINC target

P04626

PRO

P04626

PDB

4HRM, 7MN5, 4HRL, 7JXH, 7MN6, 2L4K, 8FFJ, 7MN8, 5TQS, 2N2A, 3H3B, 1MFL, 2A91, 2JWA, 7QVK, 1S78, 6BGT, 8JYR, 4NND, 6LBX, 4HRN, 3MZW, 3WSQ, 1N8Z, 8Q6J, 3BE1, 3RCD, 8U4K, 5MY6, 3PP0, 5OB4, 8U4L, 7PCD, 3WLW, 6ATT, 1MFG, 1MW4, 6OGE, 5O4G, 5K33, 2KS1, 1QR1, 3N85, 8PWH, 6J71, 4GFU, 8HGO, 5KWG, 8HGP

ZINC - Investigational

ERBB2_HUMAN

ZINC - Metabolites

ERBB2_HUMAN

COSMIC

COSV54064925, COSM4422821

GeneCards

P04626

HPA

ENSG00000141736-ERBB2

Ensembl

ENSP00000269571, ENSP00000385185, ENST00000269571, ENST00000541774, ENST00000406381, ENSP00000446466, ENSG00000141736, ENST00000584601, ENSP00000462438

Pharos - Targets

P04626

ZINC - Predictions - Purchasable

ERBB2_HUMAN

HMDB Protein

HMDBP01473

Interactors (73)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21860 ERBB3			0.973	30
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.954	25
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.926	12
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.916	8
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.856	6
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.821	16
UniProt:Q15303 ERBB4			0.816	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.793	5
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.779	5
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.775	9
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.759	12
UniProt:Q96JA1 LRIG1	2	Ub-LRIG1 [plasma membrane] (R-HSA-8875434) LRIG1 [plasma membrane] (R-HSA-197745)	0.748	7
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.708	11
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.702	8
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.695	5
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.671	4
UniProt:P02786 TFRC	5	TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829)	0.671	4
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.659	3
UniProt:Q9UJM3 ERRFI			0.659	4
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.643	3
UniProt:P0DTD8 NS7B			0.643	3
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y351-PTK6 [cytosol] (R-HSA-8857570) PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007)	0.628	4
UniProt:P98172 EFNB1	2	p-Y324,Y329,Y343-EFNB1 [plasma membrane] (R-HSA-3928412) EFNB1 [plasma membrane] (R-HSA-2682327)	0.602	12
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.602	5
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.594	3
UniProt:Q9UQF2 JIP1			0.592	4
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.592	8
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.592	3
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.592	4
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.59	10
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.59	2
IntAct:EBI-4399559 UBIQ			0.589	2
UniProt:Q9HB71 CYBP			0.573	2
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.573	2
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.571	3
UniProt:P42224 STAT1	8	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.571	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.571	2
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.569	3
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.569	3
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.567	16
UniProt:Q15075 EEA1	1	EEA1 [endosome membrane] (R-HSA-187893)	0.567	5
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733)	0.567	14
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.564	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.558	2
UniProt:Q99952 PTPN18	2	PTPN18 [nucleoplasm] (R-HSA-9008900) PTPN18 [cytosol] (R-HSA-8864101)	0.558	6
UniProt:O95980 RECK	2	cleaved GPI-RECK [extracellular region] (R-HSA-8941046) GPI-RECK [plasma membrane] (R-HSA-8940687)	0.556	4
UniProt:O75367 H2AY			0.556	6
UniProt:Q9P2T1 GMPR2	1	GMPR2 [cytosol] (R-HSA-514631)	0.553	2
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.553	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.553	2
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.547	2
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.547	2
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB [nucleoplasm] (R-HSA-3321990) ACTB [cytosol] (R-HSA-201861) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [plasma membrane] (R-HSA-196016)	0.537	10
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.536	2
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.527	2
UniProt:P36542 ATP5F1C	1	ATP5F1C [mitochondrial matrix] (R-HSA-164577)	0.527	2
UniProt:O00483 NDUFA4	1	NDUFA4 [mitochondrial inner membrane] (R-HSA-60617)	0.527	2
UniProt:O95573 ACSL3	2	ACSL3 [mitochondrial outer membrane] (R-HSA-9632656) ACSL3 [endoplasmic reticulum membrane] (R-HSA-548787)	0.527	2
UniProt:Q8WUY1 THEM6			0.527	2
UniProt:Q9NVI7 ATD3A			0.527	2
UniProt:P42704 LRPPRC	1	LRPPRC [mitochondrial matrix] (R-HSA-5336174)	0.527	2
UniProt:Q00325 S25A3			0.527	2
UniProt:Q9BVV7 TIMM21	2	TIMM21 [mitochondrial intermembrane space] (R-HSA-9865416) TIMM21 [mitochondrial inner membrane] (R-HSA-1252042)	0.527	2
UniProt:Q92504 SLC39A7	1	SLC39A7 [endoplasmic reticulum membrane] (R-HSA-442363)	0.527	2
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.527	3
UniProt:Q3ZCQ8 TIMM50	1	TIMM50 [mitochondrial inner membrane] (R-HSA-1252070)	0.527	2
UniProt:P31689 DNAJA1	2	SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072) DNAJA1 [cytosol] (R-HSA-3371544)	0.527	2
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.525	2
UniProt:Q99952-1 PTPN18			0.524	5
IntAct:EBI-5590949 HAS			0.524	2
UniProt:Q15256 PTPRR			0.508	2
UniProt:P15309 ACP3	2	ACPP [azurophil granule membrane] (R-HSA-6799214) ACPP [plasma membrane] (R-HSA-3229238)	0.472	2
UniProt:P49792 RANBP2	6	polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) RANBP2 [nuclear envelope] (R-HSA-2993756) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2 [cytosol] (R-HSA-157703)	0.463	3

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