Reactome | ERBB2 [plasma membrane]

ERBB2

Stable Identifier

R-HSA-372889

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ErbB2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P04626 ERBB2

Gene Names

ERBB2, HER2, MLN19, NEU, NGL

Chain

signal peptide:1-22, chain:23-1255

Reference Genes

BioGPS Gene:2064 ERBB2

COSMIC (genes):ERBB2 ERBB2

CTD Gene:2064 ERBB2

dbSNP Gene:2064 ERBB2

ENSEMBL:ENSG00000141736 ERBB2

HGNC:3430 ERBB2

KEGG Gene (Homo sapiens):hsa:2064 ERBB2

Monarch:2064 ERBB2

NCBI Gene:2064 ERBB2

OMIM:164870 ERBB2

UCSC:P04626 ERBB2

Reference Transcript

Other Identifiers

1060

11736472_a_at

11750611_a_at

11751416_a_at

11755005_a_at

11762165_x_at

1338

1383

16833839

1802_s_at

1901_s_at

1MFG

1MFL

1MW4

1N8Z

1OVC

1QR1

1S78

20416

2064

210930_3p_s_at

210930_s_at

216836_s_at

2A91

2JWA

2KS1

2L4K

2N2A

33218_at

3720403

3720404

3720405

3720407

3720408

3720410

3720412

3720413

3720417

3720420

3720422

3720423

3720425

3720427

3720428

3720431

3720432

3720433

3720434

3720436

3720438

3720440

3720442

3720444

3720446

3720447

3720449

3720452

3720454

3720455

3720457

3720458

3720460

3720461

3720462

3720463

3720464

3720465

3720466

3720467

3720468

3720469

3BE1

3H3B

3MZW

3N85

3PP0

3RCD

3WLW

3WSQ

4GFU

4HRL

4HRM

4HRN

5K33

5KWG

5TQS

62555

8006906

A_14_P126019

A_23_P89249

A_24_P284420

B4DTR1

CAB000043

CAB020416

CAB062555

CCDS32642

CCDS45667

CCDS74052

ENSG00000141736

ENSP00000269571

ENSP00000385185

ENSP00000446466

ENSP00000462438

ENST00000269571

ENST00000406381

ENST00000541774

ENST00000584601

EntrezGene:2064

ERBB2

ERBB2-201

ERBB2-202

ERBB2-204

ERBB2-219

g10181232_3p_a_at

GE57810

GO:0000165

GO:0000166

GO:0001042

GO:0001934

GO:0004672

GO:0004713

GO:0004714

GO:0004716

GO:0004888

GO:0005088

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006357

GO:0006468

GO:0007165

GO:0007166

GO:0007167

GO:0007169

GO:0007399

GO:0007422

GO:0007507

GO:0007528

GO:0008022

GO:0008045

GO:0008283

GO:0010008

GO:0010628

GO:0014065

GO:0014066

GO:0016020

GO:0016021

GO:0016301

GO:0016310

GO:0016323

GO:0016324

GO:0016740

GO:0018108

GO:0019838

GO:0019903

GO:0023014

GO:0030307

GO:0031410

GO:0032886

GO:0033088

GO:0035556

GO:0038111

GO:0038128

GO:0042060

GO:0042552

GO:0042802

GO:0043125

GO:0043209

GO:0043235

GO:0043406

GO:0043547

GO:0045727

GO:0045765

GO:0045785

GO:0045943

GO:0045945

GO:0046777

GO:0046854

GO:0046934

GO:0046982

GO:0046983

GO:0048015

GO:0048471

GO:0048709

GO:0050679

GO:0051897

GO:0070372

GO:0071363

GO:0071364

GO:0090314

GO:1901185

GO:2000145

HGNC:3430

HPA001060

HPA001338

HPA001383

Hs.323910.2.A1_3p_a_at

Hs.446352

ILMN_1694303

ILMN_1717902

ILMN_2352131

LRG_724

LRG_724t1

LRG_724t2

LRG_724t4

MIM:137800

MIM:164870

MIM:211980

MIM:613659

NM_001005862

NM_001289936

NM_004448

NP_001005862

NP_001276865

NP_004439

PF00757

PF01030

PF07714

PF14843

PH_hs_0021933

PR00109

SM00219

SM00261

TC17000480.hg

uc002hso.4

uc060esv.1

uc060esw.1

uc060esx.1

UPI000003F55F

UPI0000200C04

UPI0001D322F0

X03363_s_at

X5DNK3

Participant Of

hasComponent

output

TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression

Other forms of this molecule

p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y877-ERBB2 [plasma membrane]

p-Y-ERBB2 [plasma membrane]

p-Y,Y877-ERBB2 [plasma membrane]

p-6Y-ERBB2 [plasma membrane]

p-7Y-ERBB2 [plasma membrane]

p-6Y,Y1112-ERBB2 [plasma membrane]

p-7Y,Y1112-ERBB2 [plasma membrane]

Inferred To

Homologues of ERBB2 [plasma membrane] (Gallus gallus)

Homologues of ERBB2 [plasma membrane] (Rattus norvegicus)

Homologues of ERBB2 [plasma membrane] (Sus scrofa)

ERBB2 [plasma membrane] (Bos taurus)

ERBB2 [plasma membrane] (Caenorhabditis elegans)

ERBB2 [plasma membrane] (Canis familiaris)

ERBB2 [plasma membrane] (Danio rerio)

ERBB2 [plasma membrane] (Drosophila melanogaster)

ERBB2 [plasma membrane] (Gallus gallus)

ERBB2 [plasma membrane] (Mus musculus)

ERBB2 [plasma membrane] (Rattus norvegicus)

ERBB2 [plasma membrane] (Sus scrofa)

ERBB2 [plasma membrane] (Taeniopygia guttata)

ERBB2 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_004439.2, NP_001276867.1, NP_001276865.1, NP_001005862.1

Brenda

2.7.10.1

ZINC - World Drugs

ERBB2_HUMAN

ZINC - FDA approved

ERBB2_HUMAN

ZINC - Substances

ERBB2_HUMAN

ZINC target

P04626

ZINC - Biogenic

ERBB2_HUMAN

PRO

P04626

PDB

1MFG, 3RCD, 3WLW, 1MFL, 1MW4, 1N8Z, 1OVC, 5MY6, 5OB4, 3MZW, 5TQS, 3N85, 3PP0, 4HRL, 2JWA, 2A91, 1S78, 4GFU, 1QR1, 3WSQ, 3H3B, 5KWG, 3BE1, 5K33, 4HRN, 2N2A, 2L4K, 2KS1, 4HRM

ZINC - Metabolites

ERBB2_HUMAN

GeneCards

P04626

DOCK Blaster

4HRL, 3RCD, 4HRM, 3PP0, 1MFL, 3H3B, 3WSQ, 1QR1, 5K33, 4GFU, 4HRN, 3WLW, 3MZW, 1N8Z, 1S78, 1MFG, 5KWG, 2A91, 3N85, 3BE1

ZINC - Predictions - Purchasable

ERBB2_HUMAN

HMDB Protein

HMDBP01473

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21860 ERBB3			0.974	29
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.96	25
UniProt:P04626 ERBB2	12	p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079)	0.938	12
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.831	5
UniProt:P07900 HSP90AA1	7	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864)	0.825	5
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.779	5
UniProt:Q15303 ERBB4			0.778	4
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048)	0.775	9
UniProt:P12931 SRC	4	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.708	11
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276)	0.702	14
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.688	11
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937)	0.656	4
UniProt:P08238 HSP90AB1	5	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399)	0.641	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.609	2
UniProt:P16885 PLCG2	9	p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) PLCG2 [plasma membrane] (R-HSA-2023875) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) PLCG2 [cytosol] (R-HSA-1604645)	0.609	3
UniProt:O00459 PIK3R2	2	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554)	0.609	7
UniProt:P42224 STAT1	5	p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.609	3
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.602	5
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.592	8
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.592	4
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.59	2
IntAct:EBI-4399559 UBIQ			0.589	2
UniProt:Q05397 PTK2	10	p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.589	2
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.567	16
UniProt:Q15075 EEA1	1	EEA1 [endosome membrane] (R-HSA-187893)	0.567	5
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.567	14
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.564	3
UniProt:P06241 FYN	5	p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.558	2
UniProt:Q99952 PTPN18	2	PTPN18 [cytosol] (R-HSA-8864101) PTPN18 [nucleoplasm] (R-HSA-9008900)	0.558	6
UniProt:O95980 RECK	2	GPI-RECK [plasma membrane] (R-HSA-8940687) cleaved GPI-RECK [extracellular region] (R-HSA-8941046)	0.556	4
UniProt:O75367 H2AY			0.556	6
UniProt:P15309 ACPP	2	ACPP [azurophil granule membrane] (R-HSA-6799214) ACPP [plasma membrane] (R-HSA-3229238)	0.551	3
UniProt:Q9UJM3 ERRFI			0.547	3
UniProt:P60709 ACTB	5	ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [plasma membrane] (R-HSA-196016) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [lysosomal membrane] (R-HSA-196160)	0.537	10
UniProt:O95292 VAPB	1	VAPB [endoplasmic reticulum membrane] (R-HSA-429718)	0.527	2
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.527	2
UniProt:P02786 TFRC	5	TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [clathrin-coated vesicle membrane] (R-HSA-8869124)	0.527	2
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.525	2
UniProt:Q99952-1 PTPN18			0.524	5
IntAct:EBI-5590949 HAS			0.524	2
UniProt:P49792 RANBP2	2	RANBP2 [nuclear envelope] (R-HSA-2993756) RANBP2 [cytosol] (R-HSA-157703)	0.463	3
UniProt:P98172 EFNB1	2	EFNB1 [plasma membrane] (R-HSA-2682327) p-Y324,Y329,Y343-EFNB1 [plasma membrane] (R-HSA-3928412)	0.463	11