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ERBB2 [plasma membrane]
Stable Identifier
R-HSA-372889
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ErbB2
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
SEMA4D interacts with Plexin-B1:ErbB2 (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Plexin-B1:ErbB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
ERBB2 binds TKIs (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 binds trastuzumab (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 homodimerization (Homo sapiens)
ERBB2 homodimer [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)
ERBB2 homodimer [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
CUL5 mediates ubiquitination of ERBB2 (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Drug-mediated inhibition of ERBB2 signaling (Homo sapiens)
ERBB2 binds TKIs (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 binds pertuzumab (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:pertuzumab [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 binds trastuzumab (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:pertuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:pertuzumab [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
SRC family kinases phosphorylate ERBB2 (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04626 ERBB2
Gene Names
ERBB2, HER2, MLN19, NEU, NGL
Chain
signal peptide:1-22, chain:23-1255
Reference Genes
BioGPS Gene:2064 ERBB2
COSMIC (genes):ERBB2 ERBB2
CTD Gene:2064 ERBB2
dbSNP Gene:2064 ERBB2
ENSEMBL:ENSG00000141736 ERBB2
ENSEMBL:ENSG00000141736.14 ERBB2
HGNC:3430 ERBB2
KEGG Gene (Homo sapiens):2064 ERBB2
Monarch:2064 ERBB2
NCBI Gene:2064 ERBB2
OMIM:164870 ERBB2
UCSC:P04626 ERBB2
Reference Transcript
RefSeq:NM_004448.3 ERBB2
RefSeq:NM_001289938.1 ERBB2
RefSeq:NM_001289936.1 ERBB2
RefSeq:NM_001005862.2 ERBB2
Other Identifiers
11736472_a_at
11750611_a_at
11751416_a_at
11755005_a_at
11762165_x_at
16833839
1802_s_at
1901_s_at
2064
210930_3p_s_at
210930_PM_s_at
210930_s_at
216836_PM_s_at
216836_s_at
33218_at
3720403
3720404
3720405
3720406
3720407
3720408
3720410
3720411
3720412
3720413
3720417
3720420
3720422
3720423
3720425
3720427
3720428
3720431
3720432
3720433
3720434
3720436
3720438
3720440
3720442
3720444
3720446
3720447
3720449
3720452
3720454
3720455
3720457
3720458
3720460
3720461
3720462
3720463
3720464
3720465
3720466
3720467
3720468
3720469
3720470
3720471
8006906
A_14_P101724
A_14_P126019
A_23_P89249
A_24_P284420
A_33_P3292596
GE57810
GO:0000166
GO:0001042
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0004888
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006886
GO:0007155
GO:0007165
GO:0007166
GO:0007167
GO:0007169
GO:0007399
GO:0007422
GO:0007507
GO:0007528
GO:0008045
GO:0008284
GO:0009925
GO:0010008
GO:0010628
GO:0012501
GO:0014065
GO:0016020
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0018108
GO:0019838
GO:0022008
GO:0023052
GO:0030154
GO:0030182
GO:0030307
GO:0031410
GO:0031594
GO:0032587
GO:0032886
GO:0033080
GO:0033088
GO:0033674
GO:0034330
GO:0035556
GO:0036211
GO:0038127
GO:0038133
GO:0038134
GO:0038135
GO:0038143
GO:0042060
GO:0042127
GO:0042552
GO:0042734
GO:0042802
GO:0042995
GO:0043066
GO:0043125
GO:0043209
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043547
GO:0045727
GO:0045765
GO:0045785
GO:0045943
GO:0046777
GO:0046982
GO:0048471
GO:0048709
GO:0048856
GO:0050679
GO:0050790
GO:0060089
GO:0070372
GO:0071363
GO:0071364
GO:0090314
GO:0098590
GO:0099645
GO:0140096
HMNXSV003015366
HMNXSV003026104
HMNXSV003035749
Hs.323910.2.A1_3p_a_at
ILMN_1717902
ILMN_1728761
ILMN_2352131
PH_hs_0021933
TC17000480.hg
X03363_s_at
g10181232_3p_a_at
Participates
as a component of
ERBB2 homodimer [plasma membrane] (Homo sapiens)
Plexin-B1:ErbB2 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
ERBB2:trastuzumab [plasma membrane] (Homo sapiens)
ERBB2:pertuzumab [plasma membrane] (Homo sapiens)
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:ERBB2 [plasma membrane] (Homo sapiens)
as an output of
TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression (Homo sapiens)
Other forms of this molecule
ERBB2 G309E [plasma membrane]
ERBB2 G309A [plasma membrane]
ERBB2 S310F [plasma membrane]
ERBB2 S310Y [plasma membrane]
p-6Y-ERBB2 G309A [plasma membrane]
p-6Y-ERBB2 G309E [plasma membrane]
p-6Y-ERBB2 S310F [plasma membrane]
p-6Y-ERBB2 S310Y [plasma membrane]
p-Y-ERBB2 L755P [plasma membrane]
p-Y-ERBB2 I767M [plasma membrane]
p-Y-ERBB2 T798I [plasma membrane]
p-Y-ERBB2 Y772_A775dup [plasma membrane]
p-Y-ERBB2 T862A [plasma membrane]
p-Y-ERBB2 T798M [plasma membrane]
p-Y-ERBB2 H878Y [plasma membrane]
p-Y-ERBB2 V777L [plasma membrane]
p-Y-ERBB2 L755S [plasma membrane]
p-Y-ERBB2 V777E [plasma membrane]
p-Y-ERBB2 V777M [plasma membrane]
p-Y-ERBB2 L755M [plasma membrane]
p-Y-ERBB2 L755W [plasma membrane]
p-Y-ERBB2 T733I [plasma membrane]
p-Y-ERBB2 H878R [plasma membrane]
p-Y-ERBB2 L869R [plasma membrane]
p-Y-ERBB2 G776S [plasma membrane]
p-Y-ERBB2 L869Q [plasma membrane]
p-Y-ERBB2 G776L [plasma membrane]
p-Y-ERBB2 G776V [plasma membrane]
p-Y-ERBB2 G776C [plasma membrane]
ERBB2 D769Y [plasma membrane]
ERBB2 L755P [plasma membrane]
ERBB2 V842I [plasma membrane]
ERBB2 H878Y [plasma membrane]
ERBB2 T798M [plasma membrane]
ERBB2 D769H [plasma membrane]
ERBB2 T862A [plasma membrane]
ERBB2 Y772_A775dup [plasma membrane]
ERBB2 L755S [plasma membrane]
ERBB2 I767M [plasma membrane]
ERBB2 V777L [plasma membrane]
ERBB2 D769N [plasma membrane]
ERBB2 T733I [plasma membrane]
ERBB2 V777M [plasma membrane]
ERBB2 V777E [plasma membrane]
ERBB2 L755W [plasma membrane]
ERBB2 L755M [plasma membrane]
ERBB2 H878R [plasma membrane]
ERBB2 V842E [plasma membrane]
ERBB2 T798I [plasma membrane]
ERBB2 R896C [plasma membrane]
ERBB2 G778_P780dup [plasma membrane]
ERBB2 R896H [plasma membrane]
ERBB2 G776S [plasma membrane]
ERBB2 L869R [plasma membrane]
ERBB2 L869Q [plasma membrane]
ERBB2 G776C [plasma membrane]
ERBB2 G776L [plasma membrane]
ERBB2 G776V [plasma membrane]
p-6Y-ERBB2 Y772_A775dup [plasma membrane]
p-6Y-ERBB2 V777L [plasma membrane]
p-6Y-ERBB2 H878Y [plasma membrane]
ERBB2 L755_T759del [plasma membrane]
p-6Y-ERBB2 R896C [plasma membrane]
p-6Y-ERBB2 V842I [plasma membrane]
p-6Y-ERBB2 I767M [plasma membrane]
p-6Y-ERBB2 T862A [plasma membrane]
p-6Y-ERBB2 D769H [plasma membrane]
p-6Y-ERBB2 T798I [plasma membrane]
p-6Y-ERBB2 L755P [plasma membrane]
p-6Y-ERBB2 G778_P780dup [plasma membrane]
p-6Y-ERBB2 L755S [plasma membrane]
p-6Y-ERBB2 T798M [plasma membrane]
p-6Y-ERBB2 D769Y [plasma membrane]
p-6Y-ERBB2 V777E [plasma membrane]
p-6Y-ERBB2 T733I [plasma membrane]
p-6Y-ERBB2 L755M [plasma membrane]
p-6Y-ERBB2 V777M [plasma membrane]
p-6Y-ERBB2 V842E [plasma membrane]
p-6Y-ERBB2 D769N [plasma membrane]
p-6Y-ERBB2 R896H [plasma membrane]
p-6Y-ERBB2 L755W [plasma membrane]
p-6Y-ERBB2 H878R [plasma membrane]
p-6Y-ERBB2 E693K [plasma membrane]
p-6Y-ERBB2 R677L [plasma membrane]
p-6Y-ERBB2 Q709L [plasma membrane]
p-6Y-ERBB2 G660D [plasma membrane]
p-6Y-ERBB2 G660R [plasma membrane]
p-6Y-ERBB2 V659K [plasma membrane]
p-6Y-ERBB2 V659E [plasma membrane]
ERBB2 R678Q [plasma membrane]
ERBB2 S653C [plasma membrane]
ERBB2 R677L [plasma membrane]
ERBB2 G660R [plasma membrane]
ERBB2 V659E [plasma membrane]
ERBB2 G660D [plasma membrane]
ERBB2 V659K [plasma membrane]
ERBB2 Q709L [plasma membrane]
ERBB2 E693K [plasma membrane]
p-6Y-ERBB2 R678Q [plasma membrane]
p-6Y-ERBB2 S653C [plasma membrane]
p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
p-Y877-ERBB2 [plasma membrane]
p-Y-ERBB2 [plasma membrane]
p-Y,Y877-ERBB2 [plasma membrane]
p-6Y-ERBB2 [plasma membrane]
p-7Y-ERBB2 [plasma membrane]
p-6Y,Y1112-ERBB2 [plasma membrane]
p-7Y,Y1112-ERBB2 [plasma membrane]
Inferred To
ERBB2 [plasma membrane]
(Bos taurus)
ERBB2 [plasma membrane]
(Caenorhabditis elegans)
ERBB2 [plasma membrane]
(Canis familiaris)
ERBB2 [plasma membrane]
(Danio rerio)
ERBB2 [plasma membrane]
(Drosophila melanogaster)
ERBB2 [plasma membrane]
(Gallus gallus)
ERBB2 [plasma membrane]
(Mus musculus)
ERBB2 [plasma membrane]
(Rattus norvegicus)
ERBB2 [plasma membrane]
(Sus scrofa)
ERBB2 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001276865.1
,
NP_001005862.1
,
NP_001276867.1
,
NP_004439.2
ZINC - World Drugs
ERBB2_HUMAN
Guide to Pharmacology - Targets
2019
OpenTargets
ENSG00000141736
ZINC - FDA approved
ERBB2_HUMAN
ZINC - Substances
ERBB2_HUMAN
ZINC target
P04626
ZINC - Biogenic
ERBB2_HUMAN
PRO
P04626
PDB
3WLW
,
3H3B
,
2N2A
,
6ATT
,
3PP0
,
7QVK
,
1N8Z
,
4HRM
,
4HRL
,
5MY6
,
3RCD
,
8HGP
,
3BE1
,
5TQS
,
1QR1
,
3WSQ
,
3MZW
,
8HGO
,
5OB4
,
1S78
,
2JWA
,
7JXH
,
4NND
,
1MFG
,
4GFU
,
4HRN
,
8FFJ
,
7PCD
,
5KWG
,
3N85
,
2KS1
,
7MN6
,
1MW4
,
5K33
,
6J71
,
6LBX
,
1MFL
,
2A91
,
7MN5
,
5O4G
,
6BGT
,
6OGE
,
2L4K
,
7MN8
ZINC - Investigational
ERBB2_HUMAN
ZINC - Metabolites
ERBB2_HUMAN
HPA
ENSG00000141736-ERBB2
GeneCards
P04626
Ensembl
ENSP00000446466
,
ENST00000406381
,
ENST00000541774
,
ENST00000269571
,
ENSP00000385185
,
ENSP00000269571
,
ENSP00000462438
,
ENSG00000141736
,
ENST00000584601
Pharos - Targets
P04626
ZINC - Predictions - Purchasable
ERBB2_HUMAN
HMDB Protein
HMDBP01473
Interactors (72)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21860 ERBB3
0.972
29
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.954
25
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.926
12
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.916
8
UniProt:P07900 HSP90AA1
8
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.856
6
UniProt:P29353 SHC1
5
SHC1 [cytosol]
(R-HSA-74680)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
0.821
16
UniProt:Q15303 ERBB4
0.816
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.793
5
UniProt:Q14451 GRB7
1
GRB7 [cytosol]
(R-HSA-204819)
0.779
5
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.775
9
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.759
12
UniProt:Q96JA1 LRIG1
2
Ub-LRIG1 [plasma membrane]
(R-HSA-8875434)
LRIG1 [plasma membrane]
(R-HSA-197745)
0.748
7
UniProt:P12931 SRC
6
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.708
11
UniProt:O00459 PIK3R2
2
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
PIK3R2 [cytosol]
(R-HSA-74791)
0.702
8
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.695
5
UniProt:O95292 VAPB
2
VAPB [Golgi membrane]
(R-HSA-9715115)
VAPB [endoplasmic reticulum membrane]
(R-HSA-429718)
0.671
4
UniProt:P02786 TFRC
5
TFRC(1-760) [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869124)
TFRC(1-760) [Golgi membrane]
(R-HSA-434330)
TFRC(1-760) [cytoplasmic vesicle membrane]
(R-HSA-434196)
TFRC(1-760) [endosome membrane]
(R-HSA-8961829)
TFRC(1-760) [plasma membrane]
(R-HSA-917983)
0.671
4
UniProt:Q9UJM3 ERRFI
0.659
4
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.659
3
UniProt:P05023 ATP1A1
1
ATP1A1 [plasma membrane]
(R-HSA-936850)
0.643
3
UniProt:P0DTD8 NS7B
0.643
3
UniProt:Q13882 PTK6
5
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
PTK6 [cytosol]
(R-HSA-8848000)
0.628
4
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.602
5
IntAct:EBI-11820565 HSPA1A
0.594
3
UniProt:Q9UQF2 JIP1
0.592
4
UniProt:P20936 RASA1
1
RASA1 [cytosol]
(R-HSA-186833)
0.592
8
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.592
4
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.592
3
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.59
10
UniProt:P42679 MATK
1
MATK [cytosol]
(R-HSA-1433581)
0.59
2
IntAct:EBI-4399559 UBIQ
0.589
2
UniProt:Q9HB71 CYBP
0.573
2
UniProt:P31948 STIP1
1
STIP1 [cytosol]
(R-HSA-443857)
0.573
2
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.571
2
UniProt:P42224 STAT1
7
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.571
3
UniProt:P16885 PLCG2
8
p-PLCG2 [plasma membrane]
(R-HSA-114602)
PLCG2 [plasma membrane]
(R-HSA-114601)
p-Y753,Y759,Y1217-PLCG2 [plasma membrane]
(R-HSA-984816)
PLCG2 [cytosol]
(R-HSA-984806)
p-4Y-PLCG2 [plasma membrane]
(R-HSA-2685601)
p-Y753,Y759-PLCG2 [plasma membrane]
(R-HSA-5607640)
p-Y753,Y759-PLCG2 [cytosol]
(R-HSA-5607631)
p-Y-PLCG2 [cytosol]
(R-HSA-9029105)
0.571
3
UniProt:O60884 DNAJA2
1
DNAJA2 [cytosol]
(R-HSA-3371555)
0.569
3
UniProt:P27824 CANX
2
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.569
3
UniProt:Q15075 EEA1
1
EEA1 [endosome membrane]
(R-HSA-187893)
0.567
5
UniProt:Q14974 KPNB1
5
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [nucleoplasm]
(R-HSA-180714)
0.567
14
UniProt:O95602 POLR1A
1
POLR1A [nucleoplasm]
(R-HSA-63494)
0.567
16
UniProt:O14980 XPO1
2
XPO1 [nucleoplasm]
(R-HSA-165529)
XPO1 [cytosol]
(R-HSA-165539)
0.564
3
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.558
2
UniProt:Q99952 PTPN18
2
PTPN18 [nucleoplasm]
(R-HSA-9008900)
PTPN18 [cytosol]
(R-HSA-8864101)
0.558
6
UniProt:O95980 RECK
2
cleaved GPI-RECK [extracellular region]
(R-HSA-8941046)
GPI-RECK [plasma membrane]
(R-HSA-8940687)
0.556
4
UniProt:O75367 H2AY
0.556
6
UniProt:Q9P2T1 GMPR2
1
GMPR2 [cytosol]
(R-HSA-514631)
0.553
2
UniProt:P04406 GAPDH
1
GAPDH [cytosol]
(R-HSA-70428)
0.553
2
UniProt:Q9UBN7 HDAC6
4
HDAC6 [nucleoplasm]
(R-HSA-351589)
HDAC6 [late endosome lumen]
(R-HSA-9659980)
HDAC6 [cytosol]
(R-HSA-5324660)
HDAC6 [lysosomal lumen]
(R-HSA-9660002)
0.553
2
UniProt:Q9P0L0 VAPA
4
VAPA [endoplasmic reticulum membrane]
(R-HSA-429677)
VAPA [azurophil granule membrane]
(R-HSA-6799364)
VAPA [plasma membrane]
(R-HSA-6806269)
VAPA [cytosol]
(R-HSA-9609920)
0.547
2
UniProt:Q14318 FKBP8
2
PolyUb-FKBP8 [mitochondrial outer membrane]
(R-HSA-6783001)
FKBP8 [mitochondrial outer membrane]
(R-HSA-5696928)
0.547
2
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB(1-375) [nucleoplasm]
(R-HSA-3321990)
ACTB(1-375) [cytosol]
(R-HSA-201861)
ACTB(1-375) [lysosomal membrane]
(R-HSA-196160)
ACTB(1-375) [plasma membrane]
(R-HSA-196016)
0.537
10
UniProt:Q05397 PTK2
11
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
pY-PTK2 [cytosol]
(R-HSA-9632393)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.536
2
UniProt:P31689 DNAJA1
1
DNAJA1 [cytosol]
(R-HSA-3371544)
0.527
2
UniProt:P61619 SEC61A1
2
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
0.527
2
UniProt:P36542 ATP5F1C
1
ATP5C1 [mitochondrial matrix]
(R-HSA-164577)
0.527
2
UniProt:O00483 NDUFA4
1
NDUFA4 [mitochondrial inner membrane]
(R-HSA-60617)
0.527
2
UniProt:O95573 ACSL3
2
ACSL3 [endoplasmic reticulum membrane]
(R-HSA-548787)
ACSL3 [mitochondrial outer membrane]
(R-HSA-9632656)
0.527
2
UniProt:Q8WUY1 THEM6
0.527
2
UniProt:Q9NVI7 ATD3A
0.527
2
UniProt:P42704 LRPPRC
1
LRPPRC [mitochondrial matrix]
(R-HSA-5336174)
0.527
2
UniProt:Q00325 MPCP
0.527
2
UniProt:Q9BVV7 TIMM21
1
TIMM21 [mitochondrial inner membrane]
(R-HSA-1252042)
0.527
2
UniProt:Q92504 SLC39A7
1
SLC39A7 [endoplasmic reticulum membrane]
(R-HSA-442363)
0.527
2
UniProt:Q3ZCQ8 TIMM50
1
TIMM50 [mitochondrial inner membrane]
(R-HSA-1252070)
0.527
2
UniProt:O00750 PIK3C2B
1
PIK3C2B [cytosol]
(R-HSA-1604619)
0.525
2
UniProt:Q99952-1 PTPN18
0.524
5
IntAct:EBI-5590949 HAS
0.524
2
UniProt:Q15256 PTPRR
0.508
2
UniProt:P15309 ACP3
2
ACPP [plasma membrane]
(R-HSA-3229238)
ACPP [azurophil granule membrane]
(R-HSA-6799214)
0.472
2
UniProt:P98172 EFNB1
2
p-Y324,Y329,Y343-EFNB1 [plasma membrane]
(R-HSA-3928412)
EFNB1 [plasma membrane]
(R-HSA-2682327)
0.463
11
UniProt:P49792 RANBP2
6
polySUMO2-K2652,K2725-RANBP2 [nuclear envelope]
(R-HSA-4551720)
monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope]
(R-HSA-4551599)
RANBP2 [nuclear envelope]
(R-HSA-2993756)
RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9718443)
RANBP2(1-867)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9702002)
RANBP2 [cytosol]
(R-HSA-157703)
0.463
3
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