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ERBB2
Stable Identifier
R-HSA-372889
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ErbB2
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
SEMA4D interacts with Plexin-B1:ErbB2 (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Plexin-B1:ErbB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Homo sapiens)
ERBB2:ERBB2IP:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Ub-ERBB2:ERBB2IP:Ub-HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
CUL5 mediates ubiquitination of ERBB2 (Homo sapiens)
ERBB2:ERBB2IP:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Ub-ERBB2:ERBB2IP:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB2IP:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
SRC family kinases phosphorylate ERBB2 (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:ERBB3:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Homo sapiens)
ERBB2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04626 ERBB2
Gene Names
ERBB2, HER2, MLN19, NEU, NGL
Chain
signal peptide:1-22, chain:23-1255
Reference Genes
BioGPS Gene:2064 ERBB2
COSMIC (genes):ERBB2 ERBB2
CTD Gene:2064 ERBB2
dbSNP Gene:2064 ERBB2
ENSEMBL:ENSG00000141736 ERBB2
HGNC:3430 ERBB2
KEGG Gene (Homo sapiens):hsa:2064 ERBB2
Monarch:2064 ERBB2
NCBI Gene:2064 ERBB2
OMIM:164870 ERBB2
UCSC:P04626 ERBB2
Reference Transcript
RefSeq:NM_001289936.1 ERBB2
RefSeq:NM_004448.3 ERBB2
RefSeq:NM_001005862.2 ERBB2
RefSeq:NM_001289938.1 ERBB2
Other Identifiers
1060
11736472_a_at
11750611_a_at
11751416_a_at
11755005_a_at
11762165_x_at
1338
1383
16833839
1802_s_at
1901_s_at
1MFG
1MFL
1MW4
1N8Z
1OVC
1QR1
1S78
20416
2064
210930_3p_s_at
210930_s_at
216836_s_at
2A91
2JWA
2KS1
2L4K
2N2A
33218_at
3720403
3720404
3720405
3720407
3720408
3720410
3720412
3720413
3720417
3720420
3720422
3720423
3720425
3720427
3720428
3720431
3720432
3720433
3720434
3720436
3720438
3720440
3720442
3720444
3720446
3720447
3720449
3720452
3720454
3720455
3720457
3720458
3720460
3720461
3720462
3720463
3720464
3720465
3720466
3720467
3720468
3720469
3BE1
3H3B
3MZW
3N85
3PP0
3RCD
3WLW
3WSQ
43
4GFU
4HRL
4HRM
4HRN
5K33
5KWG
5TQS
62555
8006906
A_14_P126019
A_23_P89249
A_24_P284420
B4DTR1
CAB000043
CAB020416
CAB062555
CCDS32642
CCDS45667
CCDS74052
ENSG00000141736
ENSP00000269571
ENSP00000385185
ENSP00000446466
ENSP00000462438
ENST00000269571
ENST00000406381
ENST00000541774
ENST00000584601
EntrezGene:2064
ERBB2
ERBB2-201
ERBB2-202
ERBB2-204
ERBB2-219
g10181232_3p_a_at
GE57810
GO:0000165
GO:0000166
GO:0001042
GO:0001934
GO:0004672
GO:0004713
GO:0004714
GO:0004716
GO:0004888
GO:0005088
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006468
GO:0007165
GO:0007166
GO:0007167
GO:0007169
GO:0007399
GO:0007422
GO:0007507
GO:0007528
GO:0008022
GO:0008045
GO:0008283
GO:0010008
GO:0010628
GO:0014065
GO:0014066
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0018108
GO:0019838
GO:0019903
GO:0023014
GO:0030307
GO:0031410
GO:0032886
GO:0033088
GO:0035556
GO:0038111
GO:0038128
GO:0042060
GO:0042552
GO:0042802
GO:0043125
GO:0043209
GO:0043235
GO:0043406
GO:0043547
GO:0045727
GO:0045765
GO:0045785
GO:0045943
GO:0045945
GO:0046777
GO:0046854
GO:0046934
GO:0046982
GO:0046983
GO:0048015
GO:0048471
GO:0048709
GO:0050679
GO:0051897
GO:0070372
GO:0071363
GO:0071364
GO:0090314
GO:1901185
GO:2000145
HGNC:3430
HPA001060
HPA001338
HPA001383
Hs.323910.2.A1_3p_a_at
Hs.446352
ILMN_1694303
ILMN_1717902
ILMN_2352131
LRG_724
LRG_724t1
LRG_724t2
LRG_724t4
MIM:137800
MIM:164870
MIM:211980
MIM:613659
NM_001005862
NM_001289936
NM_004448
NP_001005862
NP_001276865
NP_004439
PF00757
PF01030
PF07714
PF14843
PH_hs_0021933
PR00109
SM00219
SM00261
TC17000480.hg
uc002hso.4
uc060esv.1
uc060esw.1
uc060esx.1
UPI000003F55F
UPI0000200C04
UPI0001D322F0
X03363_s_at
X5DNK3
Participant Of
hasComponent
EGF:EGFR:ERBB2 [plasma membrane]
ERBB2:ERBB2IP:HSP90:CDC37 [plasma membrane]
ERBB2:ERBB4cyt1 heterodimers [plasma membrane]
ERBB2:ERBB4cyt2 heterodimer [plasma membrane]
ERBB2:p-Y-PLXNB1 [plasma membrane]
NRG1/2:ERBB3:ERBB2 [plasma membrane]
Plexin-B1:ErbB2 [plasma membrane]
Ub-ERBB2:ERBB2IP:HSP90:CDC37 [plasma membrane]
Ub-ERBB2:ERBB2IP:Ub-HSP90:CDC37 [plasma membrane]
output
TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression
Other forms of this molecule
p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
p-Y877-ERBB2 [plasma membrane]
p-Y-ERBB2 [plasma membrane]
p-Y,Y877-ERBB2 [plasma membrane]
p-6Y-ERBB2 [plasma membrane]
p-7Y-ERBB2 [plasma membrane]
p-6Y,Y1112-ERBB2 [plasma membrane]
p-7Y,Y1112-ERBB2 [plasma membrane]
Inferred To
Homologues of ERBB2 [plasma membrane] (Gallus gallus)
Homologues of ERBB2 [plasma membrane] (Rattus norvegicus)
Homologues of ERBB2 [plasma membrane] (Sus scrofa)
ERBB2 [plasma membrane] (Bos taurus)
ERBB2 [plasma membrane] (Caenorhabditis elegans)
ERBB2 [plasma membrane] (Canis familiaris)
ERBB2 [plasma membrane] (Danio rerio)
ERBB2 [plasma membrane] (Drosophila melanogaster)
ERBB2 [plasma membrane] (Gallus gallus)
ERBB2 [plasma membrane] (Mus musculus)
ERBB2 [plasma membrane] (Rattus norvegicus)
ERBB2 [plasma membrane] (Sus scrofa)
ERBB2 [plasma membrane] (Taeniopygia guttata)
ERBB2 [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_004439.2
,
NP_001276867.1
,
NP_001276865.1
,
NP_001005862.1
Brenda
2.7.10.1
ZINC - World Drugs
ERBB2_HUMAN
ZINC - FDA approved
ERBB2_HUMAN
ZINC - Substances
ERBB2_HUMAN
ZINC target
P04626
ZINC - Biogenic
ERBB2_HUMAN
PRO
P04626
PDB
1MFG
,
3RCD
,
3WLW
,
1MFL
,
1MW4
,
1N8Z
,
1OVC
,
5MY6
,
5OB4
,
3MZW
,
5TQS
,
3N85
,
3PP0
,
4HRL
,
2JWA
,
2A91
,
1S78
,
4GFU
,
1QR1
,
3WSQ
,
3H3B
,
5KWG
,
3BE1
,
5K33
,
4HRN
,
2N2A
,
2L4K
,
2KS1
,
4HRM
ZINC - Metabolites
ERBB2_HUMAN
GeneCards
P04626
DOCK Blaster
4HRL
,
3RCD
,
4HRM
,
3PP0
,
1MFL
,
3H3B
,
3WSQ
,
1QR1
,
5K33
,
4GFU
,
4HRN
,
3WLW
,
3MZW
,
1N8Z
,
1S78
,
1MFG
,
5KWG
,
2A91
,
3N85
,
3BE1
ZINC - Predictions - Purchasable
ERBB2_HUMAN
HMDB Protein
HMDBP01473
Interactors (42)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21860 ERBB3
0.974
29
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.96
25
UniProt:P04626 ERBB2
12
p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863836)
p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863841)
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864084)
p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864090)
ERBB2 [plasma membrane]
(R-HSA-372889)
p-Y877-ERBB2 [plasma membrane]
(R-HSA-1810438)
p-Y-ERBB2 [plasma membrane]
(R-HSA-1678589)
p-Y,Y877-ERBB2 [plasma membrane]
(R-HSA-1810446)
p-6Y-ERBB2 [plasma membrane]
(R-HSA-1963569)
p-7Y-ERBB2 [plasma membrane]
(R-HSA-1248698)
p-6Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864081)
p-7Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864079)
0.938
12
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.831
5
UniProt:P07900 HSP90AA1
7
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
0.825
5
UniProt:Q14451 GRB7
1
GRB7 [cytosol]
(R-HSA-204819)
0.779
5
UniProt:Q15303 ERBB4
0.778
4
UniProt:P40763 STAT3
10
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
0.775
9
UniProt:P12931 SRC
4
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.708
11
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
SHC1 [cytosol]
(R-HSA-74680)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
0.702
14
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.688
11
UniProt:Q13882 PTK6
5
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
0.656
4
UniProt:P08238 HSP90AB1
5
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
0.641
3
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.609
2
UniProt:P16885 PLCG2
9
p-Y753,Y759,Y1217-PLCG2 [plasma membrane]
(R-HSA-984816)
PLCG2 [cytosol]
(R-HSA-984806)
p-PLCG2 [plasma membrane]
(R-HSA-114602)
PLCG2 [plasma membrane]
(R-HSA-114601)
PLCG2 [plasma membrane]
(R-HSA-2023875)
p-4Y-PLCG2 [plasma membrane]
(R-HSA-2685601)
p-Y753,Y759-PLCG2 [plasma membrane]
(R-HSA-5607640)
p-Y753,Y759-PLCG2 [cytosol]
(R-HSA-5607631)
PLCG2 [cytosol]
(R-HSA-1604645)
0.609
3
UniProt:O00459 PIK3R2
2
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
0.609
7
UniProt:P42224 STAT1
5
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
0.609
3
UniProt:P46940 IQGAP1
3
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.602
5
UniProt:P20936 RASA1
1
RASA1 [cytosol]
(R-HSA-186833)
0.592
8
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.592
4
UniProt:P42679 MATK
1
MATK [cytosol]
(R-HSA-1433581)
0.59
2
IntAct:EBI-4399559 UBIQ
0.589
2
UniProt:Q05397 PTK2
10
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.589
2
UniProt:O95602 POLR1A
1
POLR1A [nucleoplasm]
(R-HSA-63494)
0.567
16
UniProt:Q15075 EEA1
1
EEA1 [endosome membrane]
(R-HSA-187893)
0.567
5
UniProt:Q14974 KPNB1
5
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
0.567
14
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.564
3
UniProt:P06241 FYN
5
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.558
2
UniProt:Q99952 PTPN18
2
PTPN18 [cytosol]
(R-HSA-8864101)
PTPN18 [nucleoplasm]
(R-HSA-9008900)
0.558
6
UniProt:O95980 RECK
2
GPI-RECK [plasma membrane]
(R-HSA-8940687)
cleaved GPI-RECK [extracellular region]
(R-HSA-8941046)
0.556
4
UniProt:O75367 H2AY
0.556
6
UniProt:P15309 ACPP
2
ACPP [azurophil granule membrane]
(R-HSA-6799214)
ACPP [plasma membrane]
(R-HSA-3229238)
0.551
3
UniProt:Q9UJM3 ERRFI
0.547
3
UniProt:P60709 ACTB
5
ACTB(1-375) [cytosol]
(R-HSA-201861)
ACTB(1-375) [plasma membrane]
(R-HSA-196016)
ACTB(1-375) [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB(1-375) [lysosomal membrane]
(R-HSA-196160)
0.537
10
UniProt:O95292 VAPB
1
VAPB [endoplasmic reticulum membrane]
(R-HSA-429718)
0.527
2
UniProt:P05023 ATP1A1
1
ATP1A1 [plasma membrane]
(R-HSA-936850)
0.527
2
UniProt:P02786 TFRC
5
TFRC(1-760) [plasma membrane]
(R-HSA-917983)
TFRC(1-760) [endosome membrane]
(R-HSA-8961829)
TFRC(1-760) [cytoplasmic vesicle membrane]
(R-HSA-434196)
TFRC(1-760) [Golgi membrane]
(R-HSA-434330)
TFRC(1-760) [clathrin-coated vesicle membrane]
(R-HSA-8869124)
0.527
2
UniProt:O00750 PIK3C2B
1
PIK3C2B [cytosol]
(R-HSA-1604619)
0.525
2
UniProt:Q99952-1 PTPN18
0.524
5
IntAct:EBI-5590949 HAS
0.524
2
UniProt:P49792 RANBP2
2
RANBP2 [nuclear envelope]
(R-HSA-2993756)
RANBP2 [cytosol]
(R-HSA-157703)
0.463
3
UniProt:P98172 EFNB1
2
EFNB1 [plasma membrane]
(R-HSA-2682327)
p-Y324,Y329,Y343-EFNB1 [plasma membrane]
(R-HSA-3928412)
0.463
11
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