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RASA1 [cytosol]
Stable Identifier
R-HSA-186833
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ras GTPase-activating protein 1, p120-RasGAP
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
EPHB binds p120-RasGAP (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
p-EPHBs:EFNBs:RASA1 [plasma membrane] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
Ras:GTP binds p120-RasGAP (Homo sapiens)
p-EPHBs:EFNBs:RASA1 [plasma membrane] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] (Homo sapiens)
p-EPHBs:EFNBs:RASA1 [plasma membrane] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
p-EPHBs:EFNBs:RASA1:HRAS:GDP [plasma membrane] (Homo sapiens)
p-EPHBs:EFNBs:RASA1 [plasma membrane] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] (Homo sapiens)
p-EPHBs:EFNBs:RASA1 [plasma membrane] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
RAS GAPs bind RAS:GTP (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
p21 RAS:GTP:RAS GAPs [plasma membrane] (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
RAS GAPs stimulate RAS GTPase activity (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
p21 RAS:GTP:RAS GAPs [plasma membrane] (Homo sapiens)
RAS GAPs [cytosol] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
ARHGAP35 binds RASA1 (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
p-Y1105-ARHGAP35:RASA1 [cytosol] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
RASA1 binds RAS:GTP (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
p21 RAS:GTP:RASA1 [plasma membrane] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
RASA1 stimulates RAS GTPase activity (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
p-Y1105-ARHGAP35:RASA1 [cytosol] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
p21 RAS:GTP:RASA1 [plasma membrane] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
GAP binds to PDGF-beta receptors only (Homo sapiens)
Phospho-beta receptor homodimer:GAP [plasma membrane] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
RASA1:p21 RAS:GTP:SPG [plasma membrane] (Homo sapiens)
RASA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20936 RASA1
Gene Names
RASA1, GAP, RASA
Chain
chain:1-1047
Reference Genes
BioGPS Gene:5921 RASA1
COSMIC (genes):RASA1 RASA1
CTD Gene:5921 RASA1
dbSNP Gene:5921 RASA1
ENSEMBL:ENSG00000145715 RASA1
ENSEMBL_homo_sapiens_GENE:ENSG00000145715.15 RASA1
HGNC:9871 RASA1
KEGG Gene (Homo sapiens):5921 RASA1
Monarch:5921 RASA1
NCBI Gene:5921 RASA1
OMIM:139150 RASA1
UCSC:P20936 RASA1
Reference Transcript
RefSeq:NM_022650.2 RASA1
RefSeq:NM_002890.2 RASA1
Other Identifiers
11716999_a_at
11747139_a_at
1675_at
16987008
202677_PM_at
202677_at
210621_PM_s_at
210621_s_at
238243_PM_at
238243_at
2819045
2819046
2819047
2819048
2819049
2819050
2819052
2819069
2819071
2819072
2819074
2819078
2819084
2819088
2819090
2819092
2819094
2819099
2819101
2819103
2819104
2819105
2819107
2819108
2819109
2819110
2819111
2819115
2819118
2819119
2819125
2819127
2819128
2819129
2819141
2819143
36935_at
5921
75775_at
8106784
A_14_P136747
A_23_P18939
GE57879
GE84904
GO:0000278
GO:0000281
GO:0000910
GO:0001570
GO:0001726
GO:0001784
GO:0001953
GO:0003824
GO:0003924
GO:0005096
GO:0005102
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007010
GO:0007155
GO:0007162
GO:0007165
GO:0008360
GO:0012501
GO:0016787
GO:0019870
GO:0023052
GO:0030154
GO:0030833
GO:0035556
GO:0043066
GO:0043087
GO:0043524
GO:0048013
GO:0048514
GO:0048856
GO:0050896
GO:0051020
GO:0051252
GO:0065003
GO:0098772
HMNXSV003010913
Hs.185268.0.A1_3p_at
ILMN_1725312
ILMN_1737576
ILMN_2292863
M23379_at
PH_hs_0000088
TC05000431.hg
TC05002492.hg
g182973_3p_a_at
g4506430_3p_at
Participates
as an input of
EPHB binds p120-RasGAP (Homo sapiens)
ARHGAP35 binds RASA1 (Homo sapiens)
RASA1 binds RAS:GTP (Homo sapiens)
GAP binds to PDGF-beta receptors only (Homo sapiens)
as a component of
p-EPHBs:EFNBs:RASA1 [plasma membrane] (Homo sapiens)
RASA1:p21 RAS:GTP:SPG [plasma membrane] (Homo sapiens)
p-Y1105-ARHGAP35:RASA1 [cytosol] (Homo sapiens)
p21 RAS:GTP:RASA1 [plasma membrane] (Homo sapiens)
Phospho-beta receptor homodimer:GAP [plasma membrane] (Homo sapiens)
as an output of
p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Homo sapiens)
RASA1 stimulates RAS GTPase activity (Homo sapiens)
as a member of
RAS GAPs [cytosol] (Homo sapiens)
Inferred To
rasa1 [cytosol]
(Xenopus tropicalis)
vap [cytosol]
(Drosophila melanogaster)
Ghost homologue of RASA1 [cytosol]
(Caenorhabditis elegans)
Homologues of RASA1 [cytosol]
(Dictyostelium discoideum)
Homologues of RASA1 [cytosol]
(Saccharomyces cerevisiae)
Rasa1 [cytosol]
(Mus musculus)
Rasa1 [cytosol]
(Rattus norvegicus)
IRA1 [cytosol]
(Saccharomyces cerevisiae)
IRA2 [cytosol]
(Saccharomyces cerevisiae)
BUD2 [cytosol]
(Saccharomyces cerevisiae)
RASA1 [cytosol]
(Bos taurus)
RASA1 [cytosol]
(Canis familiaris)
RASA1 [cytosol]
(Dictyostelium discoideum)
RASA1 [cytosol]
(Gallus gallus)
RASA1 [cytosol]
(Sus scrofa)
nfaA [cytosol]
(Dictyostelium discoideum)
ngap [cytosol]
(Dictyostelium discoideum)
rasa1b [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_002881.1
,
NP_072179.1
OpenTargets
ENSG00000145715
GeneCards
P20936
HPA
ENSG00000145715-RASA1
Ensembl
ENSP00000423395
,
ENST00000456692
,
ENSP00000422008
,
ENST00000515800
,
ENSG00000145715
,
ENST00000274376
,
ENST00000512763
,
ENSP00000411221
,
ENSP00000274376
PRO
P20936
Pharos - Targets
P20936
Orphanet
15189
PDB
8DGQ
,
1WQ1
,
6WAX
,
1WER
,
2J05
,
2GSB
,
8BOS
,
2GQI
,
4FSS
,
2J06
,
6PXB
,
6PXC
,
2M51
,
6WAY
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96QB1 DLC1
1
DLC1 [cytosol]
(R-HSA-195140)
0.715
7
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.672
6
UniProt:P09619 PDGFRB
3
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.643
3
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.592
8
UniProt:Q13480 GAB1
4
GAB1 [cytosol]
(R-HSA-179795)
p-5Y-GAB1 [cytosol]
(R-HSA-180344)
p-Y627,Y659-GAB1 [cytosol]
(R-HSA-180496)
p-Y-GAB1 [cytosol]
(R-HSA-8855306)
0.59
25
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.59
2
UniProt:Q96IK5 GMCL1
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P04632 CAPNS1
2
CAPNS1 [cytosol]
(R-HSA-3288229)
CAPNS1 [plasma membrane]
(R-HSA-3828034)
0.524
3
UniProt:O14543 SOCS3
1
SOCS3 [cytosol]
(R-HSA-873794)
0.462
2
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