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About
What is Reactome ?
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License Agreement
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Digital Preservation
Contact us
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Ca2+ [extracellular region]
Stable Identifier
R-ALL-74112
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
Calcium, calcium(2+)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Extracellular matrix organization (Bos taurus)
Degradation of the extracellular matrix (Bos taurus)
E-cadherin degradation by ADAM10, ADAM15 (Bos taurus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
E-cadherin degradation by MMP9, KLK7 (Bos taurus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
ECM proteoglycans (Bos taurus)
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Bos taurus)
PROCR:Activated protein C [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Formation of Fibrin Clot (Clotting Cascade) (Bos taurus)
Common Pathway of Fibrin Clot Formation (Bos taurus)
Activated protein C binds Protein S (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C cleaves Factor Va intermediate form for Factor Va (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C cleaves factor VIIIa (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C cleaves factor Va to factor Vi intermediate form (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Va [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C is released from PROCR (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PROCR:Activated protein C [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated protein C:PROCR binds F2R (Bos taurus)
PROCR:Activated protein C [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PROCR:Activated protein C:F2R [plasma membrane] (Bos taurus)
PROCR:Activated protein C [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Bos taurus)
PROCR:Activated protein C [plasma membrane] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor Xa inhibitors binds Xa (Bos taurus)
factor Xa:Factor Xa inhibitors [plasma membrane] (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PROCR binds Protein C (Bos taurus)
PROCR(18-?):Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
SERPINA5 binds activated protein C (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
SERPINA5:Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Soluble PROCR binds activated protein C (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PROCR(18-?):Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor V -> factor Va + factor V activation peptide (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
SERPINA5:Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Va [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Bos taurus)
factor Va [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
SERPINA5:Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Bos taurus)
Ca2+ [extracellular region]
factor XIIIa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Xa:Factor Xa inhibitors [plasma membrane] (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Bos taurus)
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Extrinsic Pathway of Fibrin Clot Formation (Bos taurus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Bos taurus)
Ca2+ [extracellular region]
factor VII -> factor VIIa (Bos taurus)
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Bos taurus)
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Bos taurus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Bos taurus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Bos taurus)
Ca2+ [extracellular region]
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Bos taurus)
Factor IIa inhibitors (compounds) binds IIa (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Bos taurus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Bos taurus)
Ca2+ [extracellular region]
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
SERPINA5:Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Bos taurus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Bos taurus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Bos taurus)
Extracellular thrombin inactivating complexes [extracellular region] (Bos taurus)
SERPINA5:Activated protein C [extracellular region] (Bos taurus)
Activated protein C [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Bos taurus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Thrombin binding to GP1b:IX:V (Bos taurus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
Exocytosis of platelet dense granule content (Bos taurus)
Platelet dense granule content [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Thrombin signalling through proteinase activated receptors (PARs) (Bos taurus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Platelet homeostasis (Bos taurus)
Platelet calcium homeostasis (Bos taurus)
Elevation of cytosolic Ca2+ levels (Bos taurus)
Cation influx mediated by TRPC3/6/7 (Bos taurus)
Cations [extracellular region]
Ca2+ [extracellular region]
P2X1-mediated entry of Ca++ from plasma (Bos taurus)
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Bos taurus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
TRPC1 translocates calcium from the extracellular region to the cytosol (Bos taurus)
Ca2+ [extracellular region]
Innate Immune System (Bos taurus)
Antimicrobial peptides (Bos taurus)
INTL1 binds bacterial glycans (Bos taurus)
INTL1:bacterial glycan [extracellular region] (Bos taurus)
ITLN1 trimer:Ca2+ [extracellular region] (Bos taurus)
ITLNY1:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
ITLN1 trimer:Ca2+ [extracellular region] (Bos taurus)
ITLNY1:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Metal sequestration by antimicrobial proteins (Bos taurus)
S100A7 or S100A7A binds Zn2+ (Bos taurus)
S100A7, S100A7A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Bos taurus)
S100A7, S100A7A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A8:S100A9 binds Mn2+ (Bos taurus)
S100A8:S100A9:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Bos taurus)
S100A8:S100A9:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A8:S100A9 binds Zn2+ (Bos taurus)
S100A8:S100A9:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A binds bacterial phospholipids (Bos taurus)
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:phospholipids [extracellular region] (Bos taurus)
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Complement cascade (Bos taurus)
Initial triggering of complement (Bos taurus)
Conversion of C2 into C2a and C2b (Bos taurus)
C4 activators [plasma membrane] (Bos taurus)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Bos taurus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Conversion of C4 into C4a and C4b (Bos taurus)
C4 activators [plasma membrane] (Bos taurus)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Bos taurus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Creation of C4 and C2 activators (Bos taurus)
Classical antibody-mediated complement activation (Bos taurus)
Activation of C1r (Bos taurus)
C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Bos taurus)
C-reactive protein pentamer:phosphocholine [plasma membrane] (Bos taurus)
C-reactive protein homopentamer [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Lectin pathway of complement activation (Bos taurus)
Activation of MASPs (Bos taurus)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Bos taurus)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Bos taurus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
CL-LK binds carbohydrates on target cell surface (Bos taurus)
Ca2+ [extracellular region]
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ficolins bind to repetitive carbohydrate structures on the target cell surface (Bos taurus)
Ficolin-1 binds to molecular patterns on the target cell surface (Bos taurus)
Ca2+ [extracellular region]
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ficolin-2 binds to molecular patterns on the target cell surface (Bos taurus)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Bos taurus)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Regulation of Complement cascade (Bos taurus)
Thrombin, ELANE cleave C5 (Bos taurus)
Activated thrombin, (ELANE) [extracellular region] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Toll-like Receptor Cascades (Bos taurus)
Regulation of TLR by endogenous ligand (Bos taurus)
S100A1 binds TLR4:LY96 (Bos taurus)
S100A1 dimer:Ca(2+) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
S100A1:TLR4:LY96 [plasma membrane] (Bos taurus)
S100A1 dimer:Ca(2+) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Metabolism (Bos taurus)
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Calcium Influx through Voltage-gated Calcium Channels (Bos taurus)
Ca2+ [extracellular region]
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Arachidonate metabolism (Bos taurus)
Synthesis of 5-eicosatetraenoic acids (Bos taurus)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Bos taurus)
PON1,2,3:2xCa2+ dimers [extracellular region] (Bos taurus)
PON1:2xCa2+ dimer [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PON2:2xCa2+ dimer [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Acyl chain remodelling of PC (Bos taurus)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Bos taurus)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Bos taurus)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Bos taurus)
PLA2(16) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Bos taurus)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Bos taurus)
PLA2(15) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Bos taurus)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Bos taurus)
PLA2(15) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Synthesis of PA (Bos taurus)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Bos taurus)
PLA2(15) [extracellular region] (Bos taurus)
PLA2G10:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Metabolism of nucleotides (Bos taurus)
Nucleotide catabolism (Bos taurus)
Phosphate bond hydrolysis by NTPDase proteins (Bos taurus)
NTPDase1 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Bos taurus)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Bos taurus)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Bos taurus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Bos taurus)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Bos taurus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Bos taurus)
Ca2+ [extracellular region]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
Acetylcholine binding and downstream events (Bos taurus)
Postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Bos taurus)
Highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Bos taurus)
Unblocking of NMDA receptors, glutamate binding and activation (Bos taurus)
Ca2+ influx into the post-synaptic cell (Bos taurus)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Bos taurus)
Ionotropic activity of kainate receptors (Bos taurus)
Activation of Ca-permeable Kainate Receptor (Bos taurus)
Activation of Ca-permeable Kainate receptors (Bos taurus)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Bos taurus)
Activation of AMPA receptors (Bos taurus)
Activation of Ca permeable AMPA receptors (Bos taurus)
Ca2+ [extracellular region]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Bos taurus)
Ca2+ [extracellular region]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Bos taurus)
Ca2+ influx through voltage gated Ca2+ channels (Bos taurus)
Ca2+ [extracellular region]
Reproduction (Bos taurus)
Fertilization (Bos taurus)
Sperm Motility And Taxes (Bos taurus)
CatSper Channel Mediated Calcium Transport (Bos taurus)
Ca2+ [extracellular region]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
The phototransduction cascade (Bos taurus)
Activation of the phototransduction cascade (Bos taurus)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Bos taurus)
Ca2+ [extracellular region]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dissociation of RAS:RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
G alpha (q) signalling events (Bos taurus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Bos taurus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Bos taurus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Bos taurus)
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Peptide ligand-binding receptors (Bos taurus)
Proteinase-activated receptors can bind thrombin (Bos taurus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Bos taurus)
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Bos taurus)
Ca2+ [extracellular region]
Class C/3 (Metabotropic glutamate/pheromone receptors) (Bos taurus)
CASR binds Ca2+ (Bos taurus)
Ca2+ [extracellular region]
CASR:Ca2+ [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases activate IQGAPs (Bos taurus)
IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Bos taurus)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Bos taurus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
CDH1 dimer:CTTNB1:CTTNA1:IQGAP1:MEN1 [plasma membrane] (Bos taurus)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Bos taurus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Bos taurus)
Ca2+ [extracellular region]
Transport of small molecules (Bos taurus)
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)
Ca2+ [extracellular region]
Stimuli-sensing channels (Bos taurus)
TRP channels (Bos taurus)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Bos taurus)
Ca2+ [extracellular region]
TRPV1 transports Ca2+ from extracellular region to cytosol (Bos taurus)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Bos taurus)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Bos taurus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Sodium/Calcium exchangers (Bos taurus)
K+-independent Li+/Ca2+ exchanger transport (Bos taurus)
Ca2+ [extracellular region]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Bos taurus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)
Ca2+ [extracellular region]
Extracellular matrix organization (Caenorhabditis elegans)
ECM proteoglycans (Caenorhabditis elegans)
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Platelet degranulation (Caenorhabditis elegans)
Exocytosis of platelet dense granule content (Caenorhabditis elegans)
Platelet dense granule content [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Platelet homeostasis (Caenorhabditis elegans)
Platelet calcium homeostasis (Caenorhabditis elegans)
Elevation of cytosolic Ca2+ levels (Caenorhabditis elegans)
Cation influx mediated by TRPC3/6/7 (Caenorhabditis elegans)
Cations [extracellular region]
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Caenorhabditis elegans)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Signaling by the B Cell Receptor (BCR) (Caenorhabditis elegans)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Caenorhabditis elegans)
TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Innate Immune System (Caenorhabditis elegans)
Antimicrobial peptides (Caenorhabditis elegans)
PLA2G2A binds bacterial phospholipids (Caenorhabditis elegans)
PLA2G2A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2A:phospholipids [extracellular region] (Caenorhabditis elegans)
PLA2G2A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Metabolism (Caenorhabditis elegans)
Integration of energy metabolism (Caenorhabditis elegans)
Regulation of insulin secretion (Caenorhabditis elegans)
Calcium Influx through Voltage-gated Calcium Channels (Caenorhabditis elegans)
Ca2+ [extracellular region]
Metabolism of lipids (Caenorhabditis elegans)
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonate metabolism (Caenorhabditis elegans)
Synthesis of 5-eicosatetraenoic acids (Caenorhabditis elegans)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Caenorhabditis elegans)
PON1,2,3:2xCa2+ dimers [extracellular region] (Caenorhabditis elegans)
PON1:2xCa2+ dimer [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PON2:2xCa2+ dimer [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
Acyl chain remodelling of PC (Caenorhabditis elegans)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Caenorhabditis elegans)
PLA2(16) [extracellular region] (Caenorhabditis elegans)
PLA2G10:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Caenorhabditis elegans)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Caenorhabditis elegans)
PLA2(16) [extracellular region] (Caenorhabditis elegans)
PLA2G10:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Caenorhabditis elegans)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Caenorhabditis elegans)
PLA2(16) [extracellular region] (Caenorhabditis elegans)
PLA2G10:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Caenorhabditis elegans)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Caenorhabditis elegans)
PLA2(16) [extracellular region] (Caenorhabditis elegans)
PLA2G10:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Caenorhabditis elegans)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Caenorhabditis elegans)
PLA2(16) [extracellular region] (Caenorhabditis elegans)
PLA2G10:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Synthesis of PA (Caenorhabditis elegans)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Caenorhabditis elegans)
PLA2(16) [extracellular region] (Caenorhabditis elegans)
PLA2G10:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide catabolism (Caenorhabditis elegans)
Phosphate bond hydrolysis by NTPDase proteins (Caenorhabditis elegans)
NTPDase5 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Caenorhabditis elegans)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Caenorhabditis elegans)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Caenorhabditis elegans)
Cardiac conduction (Caenorhabditis elegans)
Ion homeostasis (Caenorhabditis elegans)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Caenorhabditis elegans)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Caenorhabditis elegans)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
Acetylcholine binding and downstream events (Caenorhabditis elegans)
Postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Caenorhabditis elegans)
Unblocking of NMDA receptors, glutamate binding and activation (Caenorhabditis elegans)
Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Caenorhabditis elegans)
Ionotropic activity of kainate receptors (Caenorhabditis elegans)
Activation of Ca-permeable Kainate Receptor (Caenorhabditis elegans)
Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Caenorhabditis elegans)
Activation of AMPA receptors (Caenorhabditis elegans)
Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)
Ca2+ [extracellular region]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Caenorhabditis elegans)
Ca2+ influx through voltage gated Ca2+ channels (Caenorhabditis elegans)
Ca2+ [extracellular region]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
The phototransduction cascade (Caenorhabditis elegans)
Activation of the phototransduction cascade (Caenorhabditis elegans)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Caenorhabditis elegans)
Ca2+ [extracellular region]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
MAP2K and MAPK activation (Caenorhabditis elegans)
Dissociation of RAS:RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (q) signalling events (Caenorhabditis elegans)
The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Caenorhabditis elegans)
Ca2+ [extracellular region]
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Caenorhabditis elegans)
Ca2+ [extracellular region]
Stimuli-sensing channels (Caenorhabditis elegans)
TRP channels (Caenorhabditis elegans)
TRPV1 transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Sodium/Calcium exchangers (Caenorhabditis elegans)
K+-independent Li+/Ca2+ exchanger transport (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)
Ca2+ [extracellular region]
Extracellular matrix organization (Canis familiaris)
Degradation of the extracellular matrix (Canis familiaris)
E-cadherin degradation by ADAM10, ADAM15 (Canis familiaris)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin degradation by MMP9, KLK7 (Canis familiaris)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
ECM proteoglycans (Canis familiaris)
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Canis familiaris)
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Formation of Fibrin Clot (Clotting Cascade) (Canis familiaris)
Common Pathway of Fibrin Clot Formation (Canis familiaris)
Activated protein C binds Protein S (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C cleaves Factor Va intermediate form for Factor Va (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C cleaves factor Va to factor Vi intermediate form (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Va [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C is released from PROCR (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated protein C:PROCR binds F2R (Canis familiaris)
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR:Activated protein C:F2R [plasma membrane] (Canis familiaris)
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Canis familiaris)
PROCR:Activated protein C [plasma membrane] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor Xa inhibitors binds Xa (Canis familiaris)
factor Xa:Factor Xa inhibitors [plasma membrane] (Canis familiaris)
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR binds Protein C (Canis familiaris)
PROCR(18-?):Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
SERPINA5 binds activated protein C (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
SERPINA5:Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Soluble PROCR binds activated protein C (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PROCR(18-?):Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor V -> factor Va + factor V activation peptide (Canis familiaris)
Extracellular thrombin inactivating complexes [extracellular region] (Canis familiaris)
SERPINA5:Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Va [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Canis familiaris)
factor Va [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Canis familiaris)
Extracellular thrombin inactivating complexes [extracellular region] (Canis familiaris)
SERPINA5:Activated protein C [extracellular region] (Canis familiaris)
Activated protein C [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Canis familiaris)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Canis familiaris)
Ca2+ [extracellular region]
factor XIIIa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Xa:Factor Xa inhibitors [plasma membrane] (Canis familiaris)
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Canis familiaris)
thrombin:cleaved SERPINC1 [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Extrinsic Pathway of Fibrin Clot Formation (Canis familiaris)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Canis familiaris)
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Canis familiaris)
Ca2+ [extracellular region]
factor VII -> factor VIIa (Canis familiaris)
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Canis familiaris)
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Canis familiaris)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Canis familiaris)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Canis familiaris)
Ca2+ [extracellular region]
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Canis familiaris)
Factor IIa inhibitors (compounds) binds IIa (Canis familiaris)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Canis familiaris)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
Exocytosis of platelet dense granule content (Canis familiaris)
Platelet dense granule content [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Thrombin signalling through proteinase activated receptors (PARs) (Canis familiaris)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Platelet homeostasis (Canis familiaris)
Platelet calcium homeostasis (Canis familiaris)
Elevation of cytosolic Ca2+ levels (Canis familiaris)
Cation influx mediated by TRPC3/6/7 (Canis familiaris)
Cations [extracellular region]
Ca2+ [extracellular region]
P2X1-mediated entry of Ca++ from plasma (Canis familiaris)
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Canis familiaris)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
TRPC1 translocates calcium from the extracellular region to the cytosol (Canis familiaris)
Ca2+ [extracellular region]
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Metal sequestration by antimicrobial proteins (Canis familiaris)
S100A8:S100A9 binds Mn2+ (Canis familiaris)
S100A8:S100A9:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Canis familiaris)
S100A8:S100A9:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
S100A8:S100A9 binds Zn2+ (Canis familiaris)
S100A8:S100A9:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Complement cascade (Canis familiaris)
Initial triggering of complement (Canis familiaris)
Conversion of C2 into C2a and C2b (Canis familiaris)
C4 activators [plasma membrane] (Canis familiaris)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Conversion of C4 into C4a and C4b (Canis familiaris)
C4 activators [plasma membrane] (Canis familiaris)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Creation of C4 and C2 activators (Canis familiaris)
Classical antibody-mediated complement activation (Canis familiaris)
Activation of C1r (Canis familiaris)
C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Canis familiaris)
C-reactive protein pentamer:phosphocholine [plasma membrane] (Canis familiaris)
C-reactive protein homopentamer [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Lectin pathway of complement activation (Canis familiaris)
Activation of MASPs (Canis familiaris)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
CL-LK binds carbohydrates on target cell surface (Canis familiaris)
Ca2+ [extracellular region]
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ficolins bind to repetitive carbohydrate structures on the target cell surface (Canis familiaris)
Ficolin-1 binds to molecular patterns on the target cell surface (Canis familiaris)
Ca2+ [extracellular region]
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ficolin-2 binds to molecular patterns on the target cell surface (Canis familiaris)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Regulation of Complement cascade (Canis familiaris)
Thrombin, ELANE cleave C5 (Canis familiaris)
Activated thrombin, (ELANE) [extracellular region] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Toll-like Receptor Cascades (Canis familiaris)
Regulation of TLR by endogenous ligand (Canis familiaris)
S100A1 binds TLR4:LY96 (Canis familiaris)
S100A1 dimer:Ca(2+) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
S100A1:TLR4:LY96 [plasma membrane] (Canis familiaris)
S100A1 dimer:Ca(2+) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Metabolism (Canis familiaris)
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Calcium Influx through Voltage-gated Calcium Channels (Canis familiaris)
Ca2+ [extracellular region]
Metabolism of lipids (Canis familiaris)
Fatty acid metabolism (Canis familiaris)
Arachidonate metabolism (Canis familiaris)
Synthesis of 5-eicosatetraenoic acids (Canis familiaris)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Canis familiaris)
PON1,2,3:2xCa2+ dimers [extracellular region] (Canis familiaris)
PON1:2xCa2+ dimer [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PON2:2xCa2+ dimer [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Phospholipid metabolism (Canis familiaris)
Glycerophospholipid biosynthesis (Canis familiaris)
Acyl chain remodelling of PC (Canis familiaris)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Canis familiaris)
PLA2(16) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Canis familiaris)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Canis familiaris)
PLA2(16) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Canis familiaris)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Canis familiaris)
PLA2(16) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Canis familiaris)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Canis familiaris)
PLA2(15) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Canis familiaris)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Canis familiaris)
PLA2(15) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Synthesis of PA (Canis familiaris)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Canis familiaris)
PLA2(15) [extracellular region] (Canis familiaris)
PLA2G10:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Metabolism of nucleotides (Canis familiaris)
Nucleotide catabolism (Canis familiaris)
Phosphate bond hydrolysis by NTPDase proteins (Canis familiaris)
NTPDase1 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Canis familiaris)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Ion homeostasis (Canis familiaris)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Canis familiaris)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Canis familiaris)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Canis familiaris)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Ca2+ [extracellular region]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
Acetylcholine binding and downstream events (Canis familiaris)
Postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Canis familiaris)
Highly calcium permeable nicotinic acetylcholine receptors (Canis familiaris)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Canis familiaris)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Canis familiaris)
Unblocking of NMDA receptors, glutamate binding and activation (Canis familiaris)
Ca2+ influx into the post-synaptic cell (Canis familiaris)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Canis familiaris)
Ionotropic activity of kainate receptors (Canis familiaris)
Activation of Ca-permeable Kainate Receptor (Canis familiaris)
Activation of Ca-permeable Kainate receptors (Canis familiaris)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Canis familiaris)
Activation of AMPA receptors (Canis familiaris)
Activation of Ca permeable AMPA receptors (Canis familiaris)
Ca2+ [extracellular region]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Canis familiaris)
Ca2+ influx through voltage gated Ca2+ channels (Canis familiaris)
Ca2+ [extracellular region]
Reproduction (Canis familiaris)
Fertilization (Canis familiaris)
Sperm Motility And Taxes (Canis familiaris)
CatSper Channel Mediated Calcium Transport (Canis familiaris)
Ca2+ [extracellular region]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
The phototransduction cascade (Canis familiaris)
Activation of the phototransduction cascade (Canis familiaris)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Canis familiaris)
Ca2+ [extracellular region]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
Dissociation of RAS:RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
G alpha (q) signalling events (Canis familiaris)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
GPCR ligand binding (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
Peptide ligand-binding receptors (Canis familiaris)
Proteinase-activated receptors can bind thrombin (Canis familiaris)
Thrombin:Proteinase-activated receptors [plasma membrane] (Canis familiaris)
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Canis familiaris)
Ca2+ [extracellular region]
Class C/3 (Metabotropic glutamate/pheromone receptors) (Canis familiaris)
CASR binds Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
CASR:Ca2+ [plasma membrane] (Canis familiaris)
Ca2+ [extracellular region]
GPRC6A can bind L-alpha amino acids and calcium (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Canis familiaris)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Transport of small molecules (Canis familiaris)
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)
Ca2+ [extracellular region]
Stimuli-sensing channels (Canis familiaris)
TRP channels (Canis familiaris)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Ca2+ [extracellular region]
TRPV1 transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Canis familiaris)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Sodium/Calcium exchangers (Canis familiaris)
K+-independent Li+/Ca2+ exchanger transport (Canis familiaris)
Ca2+ [extracellular region]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Canis familiaris)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)
Ca2+ [extracellular region]
Extracellular matrix organization (Danio rerio)
Degradation of the extracellular matrix (Danio rerio)
E-cadherin degradation by MMP9, KLK7 (Danio rerio)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
ECM proteoglycans (Danio rerio)
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Danio rerio)
Ca2+ [extracellular region]
Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Hemostasis (Danio rerio)
Formation of Fibrin Clot (Clotting Cascade) (Danio rerio)
Common Pathway of Fibrin Clot Formation (Danio rerio)
Activated protein C binds Protein S (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C cleaves Factor Va intermediate form for Factor Va (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C cleaves factor Va to factor Vi intermediate form (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor Va [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Factor Xa inhibitors binds Xa (Danio rerio)
factor Xa:Factor Xa inhibitors [plasma membrane] (Danio rerio)
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
SERPINA5 binds activated protein C (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
SERPINA5:Activated protein C [extracellular region] (Danio rerio)
Activated protein C [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Danio rerio)
factor Va [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Danio rerio)
Ca2+ [extracellular region]
factor XIIIa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Extrinsic Pathway of Fibrin Clot Formation (Danio rerio)
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Danio rerio)
Ca2+ [extracellular region]
factor VII -> factor VIIa (Danio rerio)
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Danio rerio)
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Danio rerio)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Danio rerio)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Danio rerio)
Ca2+ [extracellular region]
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Danio rerio)
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Danio rerio)
Platelet degranulation (Danio rerio)
Exocytosis of platelet dense granule content (Danio rerio)
Platelet dense granule content [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Platelet homeostasis (Danio rerio)
Platelet calcium homeostasis (Danio rerio)
Elevation of cytosolic Ca2+ levels (Danio rerio)
Cation influx mediated by TRPC3/6/7 (Danio rerio)
Cations [extracellular region]
Ca2+ [extracellular region]
P2X1-mediated entry of Ca++ from plasma (Danio rerio)
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Danio rerio)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Danio rerio)
Ca2+ [extracellular region]
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
Antimicrobial peptides (Danio rerio)
INTL1 binds bacterial glycans (Danio rerio)
INTL1:bacterial glycan [extracellular region] (Danio rerio)
ITLN1 trimer:Ca2+ [extracellular region] (Danio rerio)
ITLNY1:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
ITLN1 trimer:Ca2+ [extracellular region] (Danio rerio)
ITLNY1:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Metal sequestration by antimicrobial proteins (Danio rerio)
S100A7 or S100A7A binds Zn2+ (Danio rerio)
S100A7, S100A7A:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Danio rerio)
S100A7, S100A7A:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
S100A8:S100A9 binds Mn2+ (Danio rerio)
S100A8:S100A9:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Danio rerio)
S100A8:S100A9:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
S100A8:S100A9 binds Zn2+ (Danio rerio)
S100A8:S100A9:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
C-type lectin receptors (CLRs) (Danio rerio)
CD209 (DC-SIGN) signaling (Danio rerio)
CD209 binds ICAM3 (Danio rerio)
Ca2+ [extracellular region]
CD209:ICAM3:Ca+2 [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Fatty acid metabolism (Danio rerio)
Arachidonate metabolism (Danio rerio)
Synthesis of 5-eicosatetraenoic acids (Danio rerio)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Danio rerio)
PON1,2,3:2xCa2+ dimers [extracellular region] (Danio rerio)
PON1:2xCa2+ dimer [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
PON2:2xCa2+ dimer [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Phospholipid metabolism (Danio rerio)
Glycerophospholipid biosynthesis (Danio rerio)
Acyl chain remodelling of PC (Danio rerio)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Danio rerio)
PLA2(16) [extracellular region] (Danio rerio)
PLA2G10:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Danio rerio)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Danio rerio)
PLA2(16) [extracellular region] (Danio rerio)
PLA2G10:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Danio rerio)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Danio rerio)
PLA2(16) [extracellular region] (Danio rerio)
PLA2G10:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Danio rerio)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Danio rerio)
PLA2(15) [extracellular region] (Danio rerio)
PLA2G10:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Danio rerio)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Danio rerio)
PLA2(15) [extracellular region] (Danio rerio)
PLA2G10:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Synthesis of PA (Danio rerio)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Danio rerio)
PLA2(15) [extracellular region] (Danio rerio)
PLA2G10:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Danio rerio)
Ca2+ [extracellular region]
Metabolism of nucleotides (Danio rerio)
Nucleotide catabolism (Danio rerio)
Phosphate bond hydrolysis by NTPDase proteins (Danio rerio)
NTPDase2 hydrolyzes nucleoside triphosphates (Danio rerio)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Danio rerio)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Danio rerio)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Danio rerio)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Danio rerio)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Danio rerio)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Danio rerio)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Danio rerio)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Danio rerio)
Cardiac conduction (Danio rerio)
Ion homeostasis (Danio rerio)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Danio rerio)
Ca2+ [extracellular region]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter receptors and postsynaptic signal transmission (Danio rerio)
Acetylcholine binding and downstream events (Danio rerio)
Postsynaptic nicotinic acetylcholine receptors (Danio rerio)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Danio rerio)
Highly calcium permeable nicotinic acetylcholine receptors (Danio rerio)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Danio rerio)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Danio rerio)
Unblocking of NMDA receptors, glutamate binding and activation (Danio rerio)
Ca2+ influx into the post-synaptic cell (Danio rerio)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Danio rerio)
Activation of AMPA receptors (Danio rerio)
Activation of Ca permeable AMPA receptors (Danio rerio)
Ca2+ [extracellular region]
Signal Transduction (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (q) signalling events (Danio rerio)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Danio rerio)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Danio rerio)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
GPCR ligand binding (Danio rerio)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Danio rerio)
GPRC6A can bind L-alpha amino acids and calcium (Danio rerio)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Danio rerio)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases activate IQGAPs (Danio rerio)
IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Danio rerio)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Danio rerio)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
CDH1 dimer:CTTNB1:CTTNA1:IQGAP1:MEN1 [plasma membrane] (Danio rerio)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Danio rerio)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Danio rerio)
Ca2+ [extracellular region]
Transport of small molecules (Danio rerio)
Ion channel transport (Danio rerio)
Ion transport by P-type ATPases (Danio rerio)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)
Ca2+ [extracellular region]
Stimuli-sensing channels (Danio rerio)
TRP channels (Danio rerio)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Danio rerio)
Ca2+ [extracellular region]
TRPV1 transports Ca2+ from extracellular region to cytosol (Danio rerio)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Danio rerio)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Danio rerio)
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
Sodium/Calcium exchangers (Danio rerio)
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Danio rerio)
Ca2+ [extracellular region]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
Response to elevated platelet cytosolic Ca2+ (Dictyostelium discoideum)
Platelet degranulation (Dictyostelium discoideum)
Exocytosis of platelet dense granule content (Dictyostelium discoideum)
Platelet dense granule content [extracellular region] (Dictyostelium discoideum)
Ca2+ [extracellular region]
Platelet homeostasis (Dictyostelium discoideum)
Platelet calcium homeostasis (Dictyostelium discoideum)
Elevation of cytosolic Ca2+ levels (Dictyostelium discoideum)
P2X1-mediated entry of Ca++ from plasma (Dictyostelium discoideum)
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Dictyostelium discoideum)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Dictyostelium discoideum)
Ca2+ [extracellular region]
Muscle contraction (Dictyostelium discoideum)
Cardiac conduction (Dictyostelium discoideum)
Ion homeostasis (Dictyostelium discoideum)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Dictyostelium discoideum)
Ca2+ [extracellular region]
Transport of small molecules (Dictyostelium discoideum)
Ion channel transport (Dictyostelium discoideum)
Ion transport by P-type ATPases (Dictyostelium discoideum)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Dictyostelium discoideum)
Ca2+ [extracellular region]
Stimuli-sensing channels (Dictyostelium discoideum)
TRP channels (Dictyostelium discoideum)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Dictyostelium discoideum)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Dictyostelium discoideum)
Ca2+ [extracellular region]
Extracellular matrix organization (Drosophila melanogaster)
Degradation of the extracellular matrix (Drosophila melanogaster)
E-cadherin degradation by ADAM10, ADAM15 (Drosophila melanogaster)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Drosophila melanogaster)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Drosophila melanogaster)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Drosophila melanogaster)
Ca2+ [extracellular region]
E-cadherin degradation by MMP9, KLK7 (Drosophila melanogaster)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Drosophila melanogaster)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Drosophila melanogaster)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Drosophila melanogaster)
Ca2+ [extracellular region]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Autophosphorylation of SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Drosophila melanogaster)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Drosophila melanogaster)
Platelet degranulation (Drosophila melanogaster)
Exocytosis of platelet dense granule content (Drosophila melanogaster)
Platelet dense granule content [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
Platelet homeostasis (Drosophila melanogaster)
Platelet calcium homeostasis (Drosophila melanogaster)
Reduction of cytosolic Ca++ levels (Drosophila melanogaster)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Drosophila melanogaster)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Drosophila melanogaster)
Ca2+ [extracellular region]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Drosophila melanogaster)
TRPC1 translocates calcium from the extracellular region to the cytosol (Drosophila melanogaster)
Ca2+ [extracellular region]
Innate Immune System (Drosophila melanogaster)
Antimicrobial peptides (Drosophila melanogaster)
PLA2G2A binds bacterial phospholipids (Drosophila melanogaster)
PLA2G2A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2A:phospholipids [extracellular region] (Drosophila melanogaster)
PLA2G2A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
Metabolism (Drosophila melanogaster)
Integration of energy metabolism (Drosophila melanogaster)
Regulation of insulin secretion (Drosophila melanogaster)
Calcium Influx through Voltage-gated Calcium Channels (Drosophila melanogaster)
Ca2+ [extracellular region]
Metabolism of lipids (Drosophila melanogaster)
Phospholipid metabolism (Drosophila melanogaster)
Glycerophospholipid biosynthesis (Drosophila melanogaster)
Acyl chain remodelling of PC (Drosophila melanogaster)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Drosophila melanogaster)
PLA2(16) [extracellular region] (Drosophila melanogaster)
PLA2G10:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Drosophila melanogaster)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Drosophila melanogaster)
PLA2(16) [extracellular region] (Drosophila melanogaster)
PLA2G10:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Drosophila melanogaster)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Drosophila melanogaster)
PLA2(16) [extracellular region] (Drosophila melanogaster)
PLA2G10:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Drosophila melanogaster)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Drosophila melanogaster)
PLA2(15) [extracellular region] (Drosophila melanogaster)
PLA2G10:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Drosophila melanogaster)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Drosophila melanogaster)
PLA2(15) [extracellular region] (Drosophila melanogaster)
PLA2G10:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
Synthesis of PA (Drosophila melanogaster)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Drosophila melanogaster)
PLA2(15) [extracellular region] (Drosophila melanogaster)
PLA2G10:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
Metabolism of nucleotides (Drosophila melanogaster)
Nucleotide catabolism (Drosophila melanogaster)
Phosphate bond hydrolysis by NTPDase proteins (Drosophila melanogaster)
NTPDase5 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Drosophila melanogaster)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Drosophila melanogaster)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Drosophila melanogaster)
Cardiac conduction (Drosophila melanogaster)
Ion homeostasis (Drosophila melanogaster)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Drosophila melanogaster)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Drosophila melanogaster)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Drosophila melanogaster)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Drosophila melanogaster)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Drosophila melanogaster)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)
Ca2+ [extracellular region]
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter receptors and postsynaptic signal transmission (Drosophila melanogaster)
Acetylcholine binding and downstream events (Drosophila melanogaster)
Postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)
Highly calcium permeable nicotinic acetylcholine receptors (Drosophila melanogaster)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Drosophila melanogaster)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Drosophila melanogaster)
Unblocking of NMDA receptors, glutamate binding and activation (Drosophila melanogaster)
Ca2+ influx into the post-synaptic cell (Drosophila melanogaster)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Drosophila melanogaster)
Ionotropic activity of kainate receptors (Drosophila melanogaster)
Activation of Ca-permeable Kainate Receptor (Drosophila melanogaster)
Activation of Ca-permeable Kainate receptors (Drosophila melanogaster)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Drosophila melanogaster)
Activation of AMPA receptors (Drosophila melanogaster)
Activation of Ca permeable AMPA receptors (Drosophila melanogaster)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Drosophila melanogaster)
Ca2+ influx through voltage gated Ca2+ channels (Drosophila melanogaster)
Ca2+ [extracellular region]
Sensory Perception (Drosophila melanogaster)
Visual phototransduction (Drosophila melanogaster)
The phototransduction cascade (Drosophila melanogaster)
Activation of the phototransduction cascade (Drosophila melanogaster)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Drosophila melanogaster)
Ca2+ [extracellular region]
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Autophosphorylation of SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Drosophila melanogaster)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dissociation of RAS:RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (q) signalling events (Drosophila melanogaster)
The Ligand:GPCR:Gq complex dissociates (Drosophila melanogaster)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Drosophila melanogaster)
Ca2+ [extracellular region]
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Transport of small molecules (Drosophila melanogaster)
Ion channel transport (Drosophila melanogaster)
Ion transport by P-type ATPases (Drosophila melanogaster)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Drosophila melanogaster)
Ca2+ [extracellular region]
Stimuli-sensing channels (Drosophila melanogaster)
TRP channels (Drosophila melanogaster)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)
Ca2+ [extracellular region]
TRPV1 transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Drosophila melanogaster)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
Sodium/Calcium exchangers (Drosophila melanogaster)
K+-independent Li+/Ca2+ exchanger transport (Drosophila melanogaster)
Ca2+ [extracellular region]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Drosophila melanogaster)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Drosophila melanogaster)
Ca2+ [extracellular region]
Extracellular matrix organization (Gallus gallus)
Degradation of the extracellular matrix (Gallus gallus)
E-cadherin degradation by ADAM10, ADAM15 (Gallus gallus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
E-cadherin degradation by MMP9, KLK7 (Gallus gallus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
ECM proteoglycans (Gallus gallus)
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Gallus gallus)
Ca2+ [extracellular region]
Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Hemostasis (Gallus gallus)
Formation of Fibrin Clot (Clotting Cascade) (Gallus gallus)
Common Pathway of Fibrin Clot Formation (Gallus gallus)
Activated protein C binds Protein S (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Activated protein C cleaves Factor Va intermediate form for Factor Va (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Activated protein C cleaves factor VIIIa (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Activated protein C cleaves factor Va to factor Vi intermediate form (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor Va [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Activated protein C is released from PROCR (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PROCR:Activated protein C [plasma membrane] (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Activated protein C:PROCR binds F2R (Gallus gallus)
PROCR:Activated protein C [plasma membrane] (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PROCR:Activated protein C:F2R [plasma membrane] (Gallus gallus)
PROCR:Activated protein C [plasma membrane] (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Factor Xa inhibitors binds Xa (Gallus gallus)
factor Xa:Factor Xa inhibitors [plasma membrane] (Gallus gallus)
factor Xa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PROCR binds Protein C (Gallus gallus)
PROCR(18-?):Activated protein C [extracellular region] (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Soluble PROCR binds activated protein C (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PROCR(18-?):Activated protein C [extracellular region] (Gallus gallus)
Activated protein C [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor V -> factor Va + factor V activation peptide (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor Va [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Gallus gallus)
factor Va [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Gallus gallus)
Ca2+ [extracellular region]
factor XIIIa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Gallus gallus)
factor XIIIa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor Xa:Factor Xa inhibitors [plasma membrane] (Gallus gallus)
factor Xa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Gallus gallus)
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Extrinsic Pathway of Fibrin Clot Formation (Gallus gallus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Gallus gallus)
factor Xa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Gallus gallus)
Ca2+ [extracellular region]
factor VII -> factor VIIa (Gallus gallus)
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Gallus gallus)
factor Xa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Gallus gallus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Gallus gallus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Gallus gallus)
Ca2+ [extracellular region]
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Gallus gallus)
Factor IIa inhibitors (compounds) binds IIa (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Gallus gallus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Gallus gallus)
Ca2+ [extracellular region]
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Gallus gallus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Gallus gallus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Gallus gallus)
Extracellular thrombin inactivating complexes [extracellular region] (Gallus gallus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Gallus gallus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Thrombin binding to GP1b:IX:V (Gallus gallus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Gallus gallus)
Platelet degranulation (Gallus gallus)
Exocytosis of platelet dense granule content (Gallus gallus)
Platelet dense granule content [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Thrombin signalling through proteinase activated receptors (PARs) (Gallus gallus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Platelet homeostasis (Gallus gallus)
Platelet calcium homeostasis (Gallus gallus)
Elevation of cytosolic Ca2+ levels (Gallus gallus)
Cation influx mediated by TRPC3/6/7 (Gallus gallus)
Cations [extracellular region]
Ca2+ [extracellular region]
P2X1-mediated entry of Ca++ from plasma (Gallus gallus)
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Gallus gallus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Gallus gallus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Gallus gallus)
Ca2+ [extracellular region]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
TRPC1 translocates calcium from the extracellular region to the cytosol (Gallus gallus)
Ca2+ [extracellular region]
Innate Immune System (Gallus gallus)
Antimicrobial peptides (Gallus gallus)
Metal sequestration by antimicrobial proteins (Gallus gallus)
S100A7 or S100A7A binds Zn2+ (Gallus gallus)
S100A7, S100A7A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Gallus gallus)
S100A7, S100A7A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
S100A8:S100A9 binds Mn2+ (Gallus gallus)
S100A8:S100A9:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Gallus gallus)
S100A8:S100A9:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
S100A8:S100A9 binds Zn2+ (Gallus gallus)
S100A8:S100A9:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2A binds bacterial phospholipids (Gallus gallus)
PLA2G2A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2A:phospholipids [extracellular region] (Gallus gallus)
PLA2G2A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Complement cascade (Gallus gallus)
Initial triggering of complement (Gallus gallus)
Conversion of C2 into C2a and C2b (Gallus gallus)
C4 activators [plasma membrane] (Gallus gallus)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Gallus gallus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Conversion of C4 into C4a and C4b (Gallus gallus)
C4 activators [plasma membrane] (Gallus gallus)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Gallus gallus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Creation of C4 and C2 activators (Gallus gallus)
Classical antibody-mediated complement activation (Gallus gallus)
Activation of C1r (Gallus gallus)
C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Gallus gallus)
C-reactive protein pentamer:phosphocholine [plasma membrane] (Gallus gallus)
C-reactive protein homopentamer [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Lectin pathway of complement activation (Gallus gallus)
Activation of MASPs (Gallus gallus)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Gallus gallus)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Gallus gallus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
CL-LK binds carbohydrates on target cell surface (Gallus gallus)
Ca2+ [extracellular region]
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Ficolins bind to repetitive carbohydrate structures on the target cell surface (Gallus gallus)
Ficolin-1 binds to molecular patterns on the target cell surface (Gallus gallus)
Ca2+ [extracellular region]
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Ficolin-2 binds to molecular patterns on the target cell surface (Gallus gallus)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Gallus gallus)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Regulation of Complement cascade (Gallus gallus)
Thrombin, ELANE cleave C5 (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Toll-like Receptor Cascades (Gallus gallus)
Regulation of TLR by endogenous ligand (Gallus gallus)
S100A1 binds TLR4:LY96 (Gallus gallus)
S100A1 dimer:Ca(2+) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
S100A1:TLR4:LY96 [plasma membrane] (Gallus gallus)
S100A1 dimer:Ca(2+) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Innate Immune System (Gallus gallus)
Complement Cascade (Gallus gallus)
Creation of classical C3 convertase (Gallus gallus)
Classical antibody-mediated complement activation (Gallus gallus)
Activation of C1r within the C1complement complex (Gallus gallus)
IgM:Antigen:C1q:C1r:pro-C1s [plasma membrane] (Gallus gallus)
C1q:activated C1r:pro-C1s [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
IgM:Antigen:C1q:pro-C1r:pro-C1s [plasma membrane] (Gallus gallus)
C1q:pro-C1r:pro-C1s [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Antigen bound antibody interacts with C1complement complex (Gallus gallus)
C1q:pro-C1r:pro-C1s [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
IgM:Antigen:C1q:pro-C1r:pro-C1s [plasma membrane] (Gallus gallus)
C1q:pro-C1r:pro-C1s [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
C1r activates C1s component within C1 complement complex (Gallus gallus)
IgM:Antigen:C1q:C1r:pro-C1s [plasma membrane] (Gallus gallus)
C1q:activated C1r:pro-C1s [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
IgM:Antigen:Cqrs(activated C1r and C1s) [plasma membrane] (Gallus gallus)
C1q:activated C1r:activated C1s [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Cleavage of factor B to form classical C3 convertase (Gallus gallus)
C4:factor B activator [plasma membrane] (Gallus gallus)
IgM:Antigen:Cqrs(activated C1r and C1s) [plasma membrane] (Gallus gallus)
C1q:activated C1r:activated C1s [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound lectin:Ca2+:activated MASPs [plasma membrane] (Gallus gallus)
surface-bound MBL:Ca2+:activated MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound ficolin:Ca2+:activated MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
IgM:Antigen:Cqrs(activated C1r and C1s) [plasma membrane] (Gallus gallus)
C1q:activated C1r:activated C1s [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound lectin:Ca2+:activated MASPs [plasma membrane] (Gallus gallus)
surface-bound MBL:Ca2+:activated MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound ficolin:Ca2+:activated MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Lectin-mediated initiation of complement cascade (Gallus gallus)
MASPs activation (Gallus gallus)
surface-bound lectin:Ca2+:activated MASPs [plasma membrane] (Gallus gallus)
surface-bound MBL:Ca2+:activated MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound ficolin:Ca2+:activated MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound lectins:Ca2+:MASPs [plasma membrane] (Gallus gallus)
surface-bound MBL:Ca2+:MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound ficolin:Ca2+:MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
MBL or ficolin binds an oligosaccharide pattern on the target cell surface (Gallus gallus)
Ca2+ [extracellular region]
surface-bound lectins:Ca2+:MASPs [plasma membrane] (Gallus gallus)
surface-bound MBL:Ca2+:MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound ficolin:Ca2+:MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Proteolytic cleavage of complement factor C4 (Gallus gallus)
C4:factor B activator [plasma membrane] (Gallus gallus)
IgM:Antigen:Cqrs(activated C1r and C1s) [plasma membrane] (Gallus gallus)
C1q:activated C1r:activated C1s [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound lectin:Ca2+:activated MASPs [plasma membrane] (Gallus gallus)
surface-bound MBL:Ca2+:activated MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound ficolin:Ca2+:activated MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
IgM:Antigen:Cqrs(activated C1r and C1s) [plasma membrane] (Gallus gallus)
C1q:activated C1r:activated C1s [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound lectin:Ca2+:activated MASPs [plasma membrane] (Gallus gallus)
surface-bound MBL:Ca2+:activated MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
surface-bound ficolin:Ca2+:activated MASP [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Metabolism (Gallus gallus)
Integration of energy metabolism (Gallus gallus)
Regulation of insulin secretion (Gallus gallus)
Calcium Influx through Voltage-gated Calcium Channels (Gallus gallus)
Ca2+ [extracellular region]
Metabolism of lipids (Gallus gallus)
Fatty acid metabolism (Gallus gallus)
Arachidonate metabolism (Gallus gallus)
Synthesis of 5-eicosatetraenoic acids (Gallus gallus)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Gallus gallus)
PON1,2,3:2xCa2+ dimers [extracellular region] (Gallus gallus)
PON1:2xCa2+ dimer [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PON2:2xCa2+ dimer [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Phospholipid metabolism (Gallus gallus)
Glycerophospholipid biosynthesis (Gallus gallus)
Acyl chain remodelling of PC (Gallus gallus)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Gallus gallus)
PLA2(16) [extracellular region] (Gallus gallus)
PLA2G10:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Gallus gallus)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Gallus gallus)
PLA2(16) [extracellular region] (Gallus gallus)
PLA2G10:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Gallus gallus)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Gallus gallus)
PLA2(16) [extracellular region] (Gallus gallus)
PLA2G10:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Gallus gallus)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Gallus gallus)
PLA2(16) [extracellular region] (Gallus gallus)
PLA2G10:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Gallus gallus)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Gallus gallus)
PLA2(16) [extracellular region] (Gallus gallus)
PLA2G10:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Synthesis of PA (Gallus gallus)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Gallus gallus)
PLA2(16) [extracellular region] (Gallus gallus)
PLA2G10:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Metabolism of nucleotides (Gallus gallus)
Nucleotide catabolism (Gallus gallus)
Phosphate bond hydrolysis by NTPDase proteins (Gallus gallus)
NTPDase1 hydrolyzes nucleoside diphosphates (Gallus gallus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Gallus gallus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Gallus gallus)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Gallus gallus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Gallus gallus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Gallus gallus)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Gallus gallus)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Gallus gallus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Gallus gallus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Gallus gallus)
Cardiac conduction (Gallus gallus)
Ion homeostasis (Gallus gallus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Gallus gallus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Gallus gallus)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Gallus gallus)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Gallus gallus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Gallus gallus)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Gallus gallus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Gallus gallus)
Ca2+ [extracellular region]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter receptors and postsynaptic signal transmission (Gallus gallus)
Acetylcholine binding and downstream events (Gallus gallus)
Postsynaptic nicotinic acetylcholine receptors (Gallus gallus)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Gallus gallus)
Highly calcium permeable nicotinic acetylcholine receptors (Gallus gallus)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Gallus gallus)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Gallus gallus)
Unblocking of NMDA receptors, glutamate binding and activation (Gallus gallus)
Ca2+ influx into the post-synaptic cell (Gallus gallus)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Gallus gallus)
Ionotropic activity of kainate receptors (Gallus gallus)
Activation of Ca-permeable Kainate Receptor (Gallus gallus)
Activation of Ca-permeable Kainate receptors (Gallus gallus)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Gallus gallus)
Activation of AMPA receptors (Gallus gallus)
Activation of Ca permeable AMPA receptors (Gallus gallus)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Gallus gallus)
Ca2+ influx through voltage gated Ca2+ channels (Gallus gallus)
Ca2+ [extracellular region]
Sensory Perception (Gallus gallus)
Visual phototransduction (Gallus gallus)
The phototransduction cascade (Gallus gallus)
Activation of the phototransduction cascade (Gallus gallus)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Gallus gallus)
Ca2+ [extracellular region]
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
G alpha (q) signalling events (Gallus gallus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Gallus gallus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Gallus gallus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Gallus gallus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Gallus gallus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Gallus gallus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Gallus gallus)
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Gallus gallus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
GPCR ligand binding (Gallus gallus)
Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
Peptide ligand-binding receptors (Gallus gallus)
Proteinase-activated receptors can bind thrombin (Gallus gallus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Gallus gallus)
Ca2+ [extracellular region]
Class C/3 (Metabotropic glutamate/pheromone receptors) (Gallus gallus)
CASR binds Ca2+ (Gallus gallus)
Ca2+ [extracellular region]
CASR:Ca2+ [plasma membrane] (Gallus gallus)
Ca2+ [extracellular region]
GPRC6A can bind L-alpha amino acids and calcium (Gallus gallus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Gallus gallus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Transport of small molecules (Gallus gallus)
Ion channel transport (Gallus gallus)
Ion transport by P-type ATPases (Gallus gallus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Gallus gallus)
Ca2+ [extracellular region]
Stimuli-sensing channels (Gallus gallus)
TRP channels (Gallus gallus)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Gallus gallus)
Ca2+ [extracellular region]
TRPV1 transports Ca2+ from extracellular region to cytosol (Gallus gallus)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Gallus gallus)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Gallus gallus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
Sodium/Calcium exchangers (Gallus gallus)
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Gallus gallus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Gallus gallus)
Ca2+ [extracellular region]
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
Regulation of CDH11 Expression and Function (Homo sapiens)
Regulation of CDH11 function (Homo sapiens)
CDH11 homotypic and heterotypic interactions (Homo sapiens)
CDH11 forms heterotypic trans dimer with CDH24 (Homo sapiens)
Ca2+ [extracellular region]
Heterotypic CDH11:CDH24 trans dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
CDH11 forms heterotypic trans dimer with CDH8 (Homo sapiens)
Ca2+ [extracellular region]
Heterotypic CDH11:CDH8 trans dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
CDH11 forms homotypic trans dimer (Homo sapiens)
Ca2+ [extracellular region]
Homotypic CDH11 trans dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes (Homo sapiens)
CaV3.2 (CACNA1H:CACNA2D1:CACNB1,2,3:CACNG7) transports calcium from the extracellular region to the cytosol (Homo sapiens)
Ca2+ [extracellular region]
P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol (Homo sapiens)
Ca2+ [extracellular region]
PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients (Homo sapiens)
Ca2+ [extracellular region]
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients (Homo sapiens)
Ca2+ [extracellular region]
TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol (Homo sapiens)
Ca2+ [extracellular region]
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients (Homo sapiens)
Ca2+ [extracellular region]
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin (Homo sapiens)
Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis (Homo sapiens)
Ca2+ [extracellular region]
Keratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis (Homo sapiens)
Ca2+ [extracellular region]
Transit-amplifying cell of basal layer differentiates into keratinocyte of spinosum layer in interfollicular epidermis (Homo sapiens)
Ca2+ [extracellular region]
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
IRAK4 deficiency (TLR2/4) (Homo sapiens)
Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
MyD88 deficiency (TLR2/4) (Homo sapiens)
Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)
MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Diseases of hemostasis (Homo sapiens)
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) (Homo sapiens)
Defective factor IX causes hemophilia B (Homo sapiens)
Defective F9 activation (Homo sapiens)
FIX(29-461) variant is not activated (factor XIa catalyst) (Homo sapiens)
Ca2+ [extracellular region]
Defective F9 variant does not activate FX (Homo sapiens)
FIXa variant:FVIIIa does not convert FX to the active FXa (Homo sapiens)
Ca2+ [extracellular region]
Defective factor IX causes thrombophilia (Homo sapiens)
Hyperactivation of factor X by FVIIIa:FIXa R384L (Homo sapiens)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Defective factor VIII causes hemophilia A (Homo sapiens)
Defective F8 cleavage by thrombin (Homo sapiens)
F8 variant is not cleaved by thrombin (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Defective cofactor function of FVIIIa variant (Homo sapiens)
FVIIIa variant:FIXa does not convert FX to the active FXa (Homo sapiens)
Ca2+ [extracellular region]
Defective factor XII causes hereditary angioedema (Homo sapiens)
Cleavage of factor XII variant by activated thrombin (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
Influx of extracellular calcium (Homo sapiens)
Ca2+ [extracellular region]
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Listeria monocytogenes entry into host cells (Homo sapiens)
InlA-mediated entry of Listeria monocytogenes into host cells (Homo sapiens)
CBLL1 binds SRC-phosphorylated CDH1 complex (Homo sapiens)
InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane] (Homo sapiens)
InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1 [plasma membrane] (Homo sapiens)
p-Y753,Y754-CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CTNND1 [plasma membrane] (Homo sapiens)
p-Y753,Y754-CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
CBLL1 ubiqutinates the InlA-bound CDH1 complex (Homo sapiens)
InlA:Ub-K,p-Y753,Y754-CDH1:Ub-K,p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane] (Homo sapiens)
InlA:Ub-K,p-Y753,Y754-CDH1:Ub-K,p-Y-CTNNB1 [plasma membrane] (Homo sapiens)
Ub-K,p-Y-753,Y754-CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane] (Homo sapiens)
InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1 [plasma membrane] (Homo sapiens)
p-Y753,Y754-CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
InlA binds CDH1 (Homo sapiens)
CDH1:CTNNB1:CTNND1 [plasma membrane] (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
InlA:CDH1:CTNNB1:CTNND1 [plasma membrane] (Homo sapiens)
CDH1:CTNNB1:CTNND1 [plasma membrane] (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
SRC autophosphorylation is positively regulated by InlA-bound CDH1 (Homo sapiens)
InlA:CDH1:CTNNB1:CTNND1 [plasma membrane] (Homo sapiens)
CDH1:CTNNB1:CTNND1 [plasma membrane] (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
SRC phosphorylates InlA-bound CDH1 and CTNNB1 (Homo sapiens)
InlA:CDH1:CTNNB1:CTNND1 [plasma membrane] (Homo sapiens)
CDH1:CTNNB1:CTNND1 [plasma membrane] (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CTNND1 [plasma membrane] (Homo sapiens)
p-Y753,Y754-CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of anthrax toxins (Homo sapiens)
pagA binds ANTXR1 (Homo sapiens)
pagA:Ca2+ [extracellular region] (Bacillus anthracis)
Ca2+ [extracellular region]
pagA binds ANTXR2 (Homo sapiens)
pagA:Ca2+ [extracellular region] (Bacillus anthracis)
Ca2+ [extracellular region]
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
NTPDase1 hydrolyzes nucleoside triphosphates (Homo sapiens)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Homo sapiens)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
E-cadherin degradation by ADAM10, ADAM15 (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin degradation by MMP3, MMP7 and plasmin (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin degradation by MMP9, KLK7 (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin degradation by PS1:NCSTN (Gamma-secretase) (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-750 [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 732-882 [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin degradation by caspase-3 and calpain-1 (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-750 [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 751-882 [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
ECM proteoglycans (Homo sapiens)
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Homo sapiens)
Ca2+ [extracellular region]
Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
Activated protein C binds Protein S (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated protein C cleaves Factor Va intermediate form for Factor Va (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated protein C cleaves factor VIIIa (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated protein C cleaves factor Va to factor Vi intermediate form (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor Va [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated protein C is released from PROCR (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated protein C:PROCR binds F2R (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PROCR:Activated protein C:F2R [plasma membrane] (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)
PROCR:Activated protein C [plasma membrane] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Factor Xa inhibitors binds Xa (Homo sapiens)
factor Xa:Factor Xa inhibitors [plasma membrane] (Homo sapiens)
factor Xa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PROCR binds Protein C (Homo sapiens)
PROCR(18-?):Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
SERPINA5 binds activated protein C (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Soluble PROCR binds activated protein C (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PROCR(18-?):Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor V -> factor Va + factor V activation peptide (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor Va [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Homo sapiens)
factor Va [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Homo sapiens)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Homo sapiens)
Ca2+ [extracellular region]
factor XIIIa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Homo sapiens)
factor XIIIa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Homo sapiens)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor Xa:Factor Xa inhibitors [plasma membrane] (Homo sapiens)
factor Xa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Homo sapiens)
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Extrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Homo sapiens)
factor Xa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Homo sapiens)
Ca2+ [extracellular region]
factor VII -> factor VIIa (Homo sapiens)
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Homo sapiens)
factor Xa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Homo sapiens)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Homo sapiens)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Homo sapiens)
Ca2+ [extracellular region]
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
Factor IIa inhibitors (compounds) binds IIa (Homo sapiens)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Homo sapiens)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Homo sapiens)
Ca2+ [extracellular region]
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Homo sapiens)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Homo sapiens)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Homo sapiens)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)
Extracellular thrombin inactivating complexes [extracellular region] (Homo sapiens)
SERPINA5:Activated protein C [extracellular region] (Homo sapiens)
Activated protein C [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Homo sapiens)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Thrombin binding to GP1b:IX:V (Homo sapiens)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet dense granule content (Homo sapiens)
Platelet dense granule content [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
Ca2+ [extracellular region]
Cation influx mediated by TRPC3/6/7 (Homo sapiens)
Cations [extracellular region]
Ca2+ [extracellular region]
P2X1-mediated entry of Ca++ from plasma (Homo sapiens)
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Homo sapiens)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Homo sapiens)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)
Ca2+ [extracellular region]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
IKKB phosphorylates SNAP23 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)
Ca2+ [extracellular region]
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
INTL1 binds bacterial glycans (Homo sapiens)
INTL1:bacterial glycan [extracellular region] (Homo sapiens)
ITLN1 trimer:Ca2+ [extracellular region] (Homo sapiens)
ITLNY1:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
ITLN1 trimer:Ca2+ [extracellular region] (Homo sapiens)
ITLNY1:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Metal sequestration by antimicrobial proteins (Homo sapiens)
S100A7 or S100A7A binds Zn2+ (Homo sapiens)
S100A7, S100A7A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
S100A7, S100A7A:Ca2+:Zn2+ [extracellular region] (Homo sapiens)
S100A7, S100A7A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
S100A8:S100A9 binds Mn2+ (Homo sapiens)
S100A8:S100A9:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Homo sapiens)
S100A8:S100A9:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
S100A8:S100A9 binds Zn2+ (Homo sapiens)
S100A8:S100A9:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2A binds bacterial phospholipids (Homo sapiens)
PLA2G2A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2A:phospholipids [extracellular region] (Homo sapiens)
PLA2G2A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
C-type lectin receptors (CLRs) (Homo sapiens)
CD209 (DC-SIGN) signaling (Homo sapiens)
CD209 binds ICAM3 (Homo sapiens)
Ca2+ [extracellular region]
CD209:ICAM3:Ca+2 [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Complement cascade (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Conversion of C2 into C2a and C2b (Homo sapiens)
C4 activators [plasma membrane] (Homo sapiens)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Conversion of C4 into C4a and C4b (Homo sapiens)
C4 activators [plasma membrane] (Homo sapiens)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Creation of C4 and C2 activators (Homo sapiens)
Classical antibody-mediated complement activation (Homo sapiens)
Activation of C1r (Homo sapiens)
C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Homo sapiens)
C-reactive protein pentamer:phosphocholine [plasma membrane] (Homo sapiens)
C-reactive protein homopentamer [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Lectin pathway of complement activation (Homo sapiens)
Activation of MASPs (Homo sapiens)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
FCN3 ligands:FCN3 multimer:MASP1 dimer:MASP2 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
CL-LK binds carbohydrates on target cell surface (Homo sapiens)
Ca2+ [extracellular region]
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ficolins bind to repetitive carbohydrate structures on the target cell surface (Homo sapiens)
Ficolin-1 binds to molecular patterns on the target cell surface (Homo sapiens)
Ca2+ [extracellular region]
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ficolin-2 binds to molecular patterns on the target cell surface (Homo sapiens)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ficolin-3 binds to molecular patterns on the target cell surface (Homo sapiens)
Ca2+ [extracellular region]
FCN3 ligands:FCN3 multimer:MASP1 dimer:MASP2 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Regulation of Complement cascade (Homo sapiens)
Thrombin, ELANE cleave C5 (Homo sapiens)
Activated thrombin, (ELANE) [extracellular region] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Toll-like Receptor Cascades (Homo sapiens)
Regulation of TLR by endogenous ligand (Homo sapiens)
S100A1 binds TLR4:LY96 (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
S100A1:TLR4:LY96 [plasma membrane] (Homo sapiens)
S100A1 dimer:Ca(2+) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Calcium Influx through Voltage-gated Calcium Channels (Homo sapiens)
Ca2+ [extracellular region]
Exocytosis of Insulin (Homo sapiens)
Ca2+ [extracellular region]
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Homo sapiens)
PON1,2,3:2xCa2+ dimers [extracellular region] (Homo sapiens)
PON1:2xCa2+ dimer [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PON2:2xCa2+ dimer [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Acyl chain remodelling of PC (Homo sapiens)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Homo sapiens)
PLA2(16) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Homo sapiens)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Homo sapiens)
PLA2(16) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Homo sapiens)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Homo sapiens)
PLA2(16) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Homo sapiens)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Homo sapiens)
PLA2(15) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Homo sapiens)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Homo sapiens)
PLA2(15) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Synthesis of PA (Homo sapiens)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Homo sapiens)
PLA2(15) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Metabolism of nucleotides (Homo sapiens)
Nucleotide catabolism (Homo sapiens)
Phosphate bond hydrolysis by NTPDase proteins (Homo sapiens)
NTPDase1 hydrolyzes nucleoside diphosphates (Homo sapiens)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Homo sapiens)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Homo sapiens)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Homo sapiens)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Homo sapiens)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Homo sapiens)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Homo sapiens)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Homo sapiens)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Homo sapiens)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Amyloid fibrils have additional components (Homo sapiens)
Amyloid fibrils [plasma membrane] (Homo sapiens)
Serum amyloid P-component homopentamer [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Serum amyloid P-component homopentamer [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Formation of serum amyloid P decamer (Homo sapiens)
Serum amyloid P decamer [extracellular region] (Homo sapiens)
Serum amyloid P-component homopentamer [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Serum amyloid P-component homopentamer [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Serum amyloid P binds DNA and chromatin (Homo sapiens)
Serum amyloid P-component homopentamer [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Serum amyloid P-component pentamer:Double-stranded DNA [extracellular region] (Homo sapiens)
Serum amyloid P-component homopentamer [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Serum amyloid P-component forms homopentamers (Homo sapiens)
Ca2+ [extracellular region]
Serum amyloid P-component homopentamer [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Homo sapiens)
Ca2+ [extracellular region]
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Homo sapiens)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Homo sapiens)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Homo sapiens)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Homo sapiens)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Homo sapiens)
Ca2+ [extracellular region]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Acetylcholine binding and downstream events (Homo sapiens)
Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
Highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
Ca2+ influx into the post-synaptic cell (Homo sapiens)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Homo sapiens)
Ionotropic activity of kainate receptors (Homo sapiens)
Activation of Ca-permeable Kainate Receptor (Homo sapiens)
Activation of Ca-permeable Kainate receptors (Homo sapiens)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
Activation of AMPA receptors (Homo sapiens)
Activation of Ca permeable AMPA receptors (Homo sapiens)
Ca2+ [extracellular region]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Homo sapiens)
Ca2+ [extracellular region]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Homo sapiens)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Homo sapiens)
Ca2+ influx through voltage gated Ca2+ channels (Homo sapiens)
Ca2+ [extracellular region]
Reproduction (Homo sapiens)
Fertilization (Homo sapiens)
Sperm Motility And Taxes (Homo sapiens)
CatSper Channel Mediated Calcium Transport (Homo sapiens)
Ca2+ [extracellular region]
Sensory Perception (Homo sapiens)
Olfactory Signaling Pathway (Homo sapiens)
cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol (Homo sapiens)
Ca2+ [extracellular region]
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)
Ca2+ [extracellular region]
ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)
Ca2+ [extracellular region]
CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell (Homo sapiens)
Ca2+ [extracellular region]
Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
Ca2+ [extracellular region]
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)
Ca2+ [extracellular region]
Acetylcholine inhibits contraction of outer hair cells (Homo sapiens)
CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol (Homo sapiens)
Ca2+ [extracellular region]
Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)
Ca2+ [extracellular region]
Visual phototransduction (Homo sapiens)
The phototransduction cascade (Homo sapiens)
Activation of the phototransduction cascade (Homo sapiens)
SLC24A1 exchanges 4Na+ for Ca2+, K+ (Homo sapiens)
Ca2+ [extracellular region]
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Homo sapiens)
Ca2+ [extracellular region]
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Proteinase-activated receptors can bind thrombin (Homo sapiens)
Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Homo sapiens)
Ca2+ [extracellular region]
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
CASR binds Ca2+ (Homo sapiens)
Ca2+ [extracellular region]
CASR:Ca2+ [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
GPRC6A can bind L-alpha amino acids and calcium (Homo sapiens)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate IQGAPs (Homo sapiens)
IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Homo sapiens)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
CDH1 dimer:CTTNB1:CTTNA1:IQGAP1:MEN1 [plasma membrane] (Homo sapiens)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Homo sapiens)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Homo sapiens)
Ca2+ [extracellular region]
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Homo sapiens)
Ca2+ [extracellular region]
Stimuli-sensing channels (Homo sapiens)
TRP channels (Homo sapiens)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Homo sapiens)
Ca2+ [extracellular region]
TRPV1 transports Ca2+ from extracellular region to cytosol (Homo sapiens)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Homo sapiens)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Sodium/Calcium exchangers (Homo sapiens)
K+-independent Li+/Ca2+ exchanger transport (Homo sapiens)
Ca2+ [extracellular region]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)
Ca2+ [extracellular region]
Extracellular matrix organization (Mus musculus)
Degradation of the extracellular matrix (Mus musculus)
E-cadherin degradation by ADAM10, ADAM15 (Mus musculus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
E-cadherin degradation by MMP9, KLK7 (Mus musculus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
ECM proteoglycans (Mus musculus)
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Mus musculus)
Ca2+ [extracellular region]
Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Hemostasis (Mus musculus)
Cell surface interactions at the vascular wall (Mus musculus)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Mus musculus)
PROCR:Activated protein C [plasma membrane] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Formation of Fibrin Clot (Clotting Cascade) (Mus musculus)
Common Pathway of Fibrin Clot Formation (Mus musculus)
Activated protein C binds Protein S (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Activated protein C cleaves Factor Va intermediate form for Factor Va (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Activated protein C cleaves factor VIIIa (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Activated protein C cleaves factor Va to factor Vi intermediate form (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor Va [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Activated protein C is released from PROCR (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PROCR:Activated protein C [plasma membrane] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Activated protein C:PROCR binds F2R (Mus musculus)
PROCR:Activated protein C [plasma membrane] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PROCR:Activated protein C:F2R [plasma membrane] (Mus musculus)
PROCR:Activated protein C [plasma membrane] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Mus musculus)
PROCR:Activated protein C [plasma membrane] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Factor Xa inhibitors binds Xa (Mus musculus)
factor Xa:Factor Xa inhibitors [plasma membrane] (Mus musculus)
factor Xa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PROCR binds Protein C (Mus musculus)
PROCR(18-?):Activated protein C [extracellular region] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
SERPINA5 binds activated protein C (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
SERPINA5:Activated protein C [extracellular region] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Soluble PROCR binds activated protein C (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PROCR(18-?):Activated protein C [extracellular region] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor V -> factor Va + factor V activation peptide (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
SERPINA5:Activated protein C [extracellular region] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor Va [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Mus musculus)
factor Va [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
SERPINA5:Activated protein C [extracellular region] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Mus musculus)
Ca2+ [extracellular region]
factor XIIIa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Mus musculus)
factor XIIIa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
SERPINA5:Activated protein C [extracellular region] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor Xa:Factor Xa inhibitors [plasma membrane] (Mus musculus)
factor Xa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Extrinsic Pathway of Fibrin Clot Formation (Mus musculus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Mus musculus)
factor Xa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Mus musculus)
Ca2+ [extracellular region]
factor VII -> factor VIIa (Mus musculus)
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Mus musculus)
factor Xa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Mus musculus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Mus musculus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Mus musculus)
Ca2+ [extracellular region]
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Mus musculus)
Factor IIa inhibitors (compounds) binds IIa (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Mus musculus)
Ca2+ [extracellular region]
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
SERPINA5:Activated protein C [extracellular region] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Mus musculus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Mus musculus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
SERPINA5:Activated protein C [extracellular region] (Mus musculus)
Activated protein C [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
Autophosphorylation of PTK2 at Y397 (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Thrombin binding to GP1b:IX:V (Mus musculus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Mus musculus)
Platelet degranulation (Mus musculus)
Exocytosis of platelet dense granule content (Mus musculus)
Platelet dense granule content [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Thrombin signalling through proteinase activated receptors (PARs) (Mus musculus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Platelet homeostasis (Mus musculus)
Platelet calcium homeostasis (Mus musculus)
Elevation of cytosolic Ca2+ levels (Mus musculus)
Cation influx mediated by TRPC3/6/7 (Mus musculus)
Cations [extracellular region]
Ca2+ [extracellular region]
P2X1-mediated entry of Ca++ from plasma (Mus musculus)
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Mus musculus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Mus musculus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Mus musculus)
Ca2+ [extracellular region]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
TRPC1 translocates calcium from the extracellular region to the cytosol (Mus musculus)
Ca2+ [extracellular region]
Innate Immune System (Mus musculus)
Antimicrobial peptides (Mus musculus)
INTL1 binds bacterial glycans (Mus musculus)
INTL1:bacterial glycan [extracellular region] (Mus musculus)
ITLN1 trimer:Ca2+ [extracellular region] (Mus musculus)
ITLNY1:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
ITLN1 trimer:Ca2+ [extracellular region] (Mus musculus)
ITLNY1:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Metal sequestration by antimicrobial proteins (Mus musculus)
S100A8:S100A9 binds Mn2+ (Mus musculus)
S100A8:S100A9:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Mus musculus)
S100A8:S100A9:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
S100A8:S100A9 binds Zn2+ (Mus musculus)
S100A8:S100A9:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2A binds bacterial phospholipids (Mus musculus)
PLA2G2A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2A:phospholipids [extracellular region] (Mus musculus)
PLA2G2A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Complement cascade (Mus musculus)
Initial triggering of complement (Mus musculus)
Conversion of C2 into C2a and C2b (Mus musculus)
C4 activators [plasma membrane] (Mus musculus)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Mus musculus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Conversion of C4 into C4a and C4b (Mus musculus)
C4 activators [plasma membrane] (Mus musculus)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Mus musculus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Creation of C4 and C2 activators (Mus musculus)
Classical antibody-mediated complement activation (Mus musculus)
Activation of C1r (Mus musculus)
C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Mus musculus)
C-reactive protein pentamer:phosphocholine [plasma membrane] (Mus musculus)
C-reactive protein homopentamer [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Lectin pathway of complement activation (Mus musculus)
Activation of MASPs (Mus musculus)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Mus musculus)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Mus musculus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
CL-LK binds carbohydrates on target cell surface (Mus musculus)
Ca2+ [extracellular region]
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Ficolins bind to repetitive carbohydrate structures on the target cell surface (Mus musculus)
Ficolin-1 binds to molecular patterns on the target cell surface (Mus musculus)
Ca2+ [extracellular region]
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Ficolin-2 binds to molecular patterns on the target cell surface (Mus musculus)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Mus musculus)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Regulation of Complement cascade (Mus musculus)
Thrombin, ELANE cleave C5 (Mus musculus)
Activated thrombin, (ELANE) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Toll-like Receptor Cascades (Mus musculus)
Regulation of TLR by endogenous ligand (Mus musculus)
S100A1 binds TLR4:LY96 (Mus musculus)
S100A1 dimer:Ca(2+) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
S100A1:TLR4:LY96 [plasma membrane] (Mus musculus)
S100A1 dimer:Ca(2+) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Metabolism (Mus musculus)
Integration of energy metabolism (Mus musculus)
Regulation of insulin secretion (Mus musculus)
Calcium Influx through Voltage-gated Calcium Channels (Mus musculus)
Ca2+ [extracellular region]
Metabolism of lipids (Mus musculus)
Fatty acid metabolism (Mus musculus)
Arachidonate metabolism (Mus musculus)
Synthesis of 5-eicosatetraenoic acids (Mus musculus)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Mus musculus)
PON1,2,3:2xCa2+ dimers [extracellular region] (Mus musculus)
PON1:2xCa2+ dimer [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PON2:2xCa2+ dimer [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Phospholipid metabolism (Mus musculus)
Glycerophospholipid biosynthesis (Mus musculus)
Acyl chain remodelling of PC (Mus musculus)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Mus musculus)
PLA2(16) [extracellular region] (Mus musculus)
PLA2G10:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Mus musculus)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Mus musculus)
PLA2(16) [extracellular region] (Mus musculus)
PLA2G10:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Mus musculus)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Mus musculus)
PLA2(16) [extracellular region] (Mus musculus)
PLA2G10:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Mus musculus)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Mus musculus)
PLA2(15) [extracellular region] (Mus musculus)
PLA2G10:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Mus musculus)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Mus musculus)
PLA2(15) [extracellular region] (Mus musculus)
PLA2G10:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Synthesis of PA (Mus musculus)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Mus musculus)
PLA2(15) [extracellular region] (Mus musculus)
PLA2G10:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2E:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Metabolism of nucleotides (Mus musculus)
Nucleotide catabolism (Mus musculus)
Phosphate bond hydrolysis by NTPDase proteins (Mus musculus)
NTPDase1 hydrolyzes nucleoside diphosphates (Mus musculus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Mus musculus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Mus musculus)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Mus musculus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Mus musculus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Mus musculus)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Mus musculus)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Mus musculus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Mus musculus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Muscle contraction (Mus musculus)
Cardiac conduction (Mus musculus)
Ion homeostasis (Mus musculus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Mus musculus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Mus musculus)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Mus musculus)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Mus musculus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Mus musculus)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Mus musculus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Mus musculus)
Ca2+ [extracellular region]
Neuronal System (Mus musculus)
Transmission across Chemical Synapses (Mus musculus)
Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
Acetylcholine binding and downstream events (Mus musculus)
Postsynaptic nicotinic acetylcholine receptors (Mus musculus)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Mus musculus)
Highly calcium permeable nicotinic acetylcholine receptors (Mus musculus)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Mus musculus)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Mus musculus)
Unblocking of NMDA receptors, glutamate binding and activation (Mus musculus)
Ca2+ influx into the post-synaptic cell (Mus musculus)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Mus musculus)
Ionotropic activity of kainate receptors (Mus musculus)
Activation of Ca-permeable Kainate Receptor (Mus musculus)
Activation of Ca-permeable Kainate receptors (Mus musculus)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Mus musculus)
Activation of AMPA receptors (Mus musculus)
Activation of Ca permeable AMPA receptors (Mus musculus)
Ca2+ [extracellular region]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Mus musculus)
Ca2+ [extracellular region]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Mus musculus)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Mus musculus)
Ca2+ influx through voltage gated Ca2+ channels (Mus musculus)
Ca2+ [extracellular region]
Reproduction (Mus musculus)
Fertilization (Mus musculus)
Sperm Motility And Taxes (Mus musculus)
CatSper Channel Mediated Calcium Transport (Mus musculus)
Ca2+ [extracellular region]
Sensory Perception (Mus musculus)
Visual phototransduction (Mus musculus)
The phototransduction cascade (Mus musculus)
Activation of the phototransduction cascade (Mus musculus)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Mus musculus)
Ca2+ [extracellular region]
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
Autophosphorylation of PTK2 at Y397 (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dissociation of RAS:RAF complex (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
The Ligand:GPCR:Gi complex dissociates (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
G alpha (q) signalling events (Mus musculus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Mus musculus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Mus musculus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Mus musculus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Mus musculus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
The Ligand:GPCR:Gq complex dissociates (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Mus musculus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Ligands of GPCRs that activate Gq/11 [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
GPCR ligand binding (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
Peptide ligand-binding receptors (Mus musculus)
Proteinase-activated receptors can bind thrombin (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Ca2+ [extracellular region]
Class C/3 (Metabotropic glutamate/pheromone receptors) (Mus musculus)
CASR binds Ca2+ (Mus musculus)
Ca2+ [extracellular region]
CASR:Ca2+ [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
GPRC6A can bind L-alpha amino acids and calcium (Mus musculus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Mus musculus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases activate IQGAPs (Mus musculus)
IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Mus musculus)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Mus musculus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
CDH1 dimer:CTTNB1:CTTNA1:IQGAP1:MEN1 [plasma membrane] (Mus musculus)
CDH1 dimer:CTNNB1:CTNNA1 [plasma membrane] (Mus musculus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Mus musculus)
Ca2+ [extracellular region]
Transport of small molecules (Mus musculus)
Ion channel transport (Mus musculus)
Ion transport by P-type ATPases (Mus musculus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Mus musculus)
Ca2+ [extracellular region]
Stimuli-sensing channels (Mus musculus)
TRP channels (Mus musculus)
TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Mus musculus)
Ca2+ [extracellular region]
TRPV1 transports Ca2+ from extracellular region to cytosol (Mus musculus)
Ca2+ [extracellular region]
TRPs transport extracellular Ca2+ to cytosol (Mus musculus)
Ca2+ [extracellular region]
SLC-mediated transmembrane transport (Mus musculus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
Sodium/Calcium exchangers (Mus musculus)
K+-independent Li+/Ca2+ exchanger transport (Mus musculus)
Ca2+ [extracellular region]
SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Mus musculus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Mus musculus)
Ca2+ [extracellular region]
Hemostasis (Plasmodium falciparum)
Platelet activation, signaling and aggregation (Plasmodium falciparum)
Response to elevated platelet cytosolic Ca2+ (Plasmodium falciparum)
Platelet degranulation (Plasmodium falciparum)
Exocytosis of platelet dense granule content (Plasmodium falciparum)
Platelet dense granule content [extracellular region] (Plasmodium falciparum)
Ca2+ [extracellular region]
Metabolism (Plasmodium falciparum)
Metabolism of nucleotides (Plasmodium falciparum)
Nucleotide catabolism (Plasmodium falciparum)
Phosphate bond hydrolysis by NTPDase proteins (Plasmodium falciparum)
NTPDase1 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Extracellular matrix organization (Rattus norvegicus)
Degradation of the extracellular matrix (Rattus norvegicus)
E-cadherin degradation by ADAM10, ADAM15 (Rattus norvegicus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
E-cadherin degradation by MMP9, KLK7 (Rattus norvegicus)
CDH1(155-882):Ca2+ dimer [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 155-700 [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
E-cadherin strand dimer fragment 701-882 [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
ECM proteoglycans (Rattus norvegicus)
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Rattus norvegicus)
Ca2+ [extracellular region]
Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Hemostasis (Rattus norvegicus)
Cell surface interactions at the vascular wall (Rattus norvegicus)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Rattus norvegicus)
PROCR:Activated protein C [plasma membrane] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Formation of Fibrin Clot (Clotting Cascade) (Rattus norvegicus)
Common Pathway of Fibrin Clot Formation (Rattus norvegicus)
Activated protein C binds Protein S (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Activated protein C cleaves factor VIIIa (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Activated protein C:Protein S [plasma membrane] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Activated protein C is released from PROCR (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PROCR:Activated protein C [plasma membrane] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Activated protein C:PROCR binds F2R (Rattus norvegicus)
PROCR:Activated protein C [plasma membrane] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PROCR:Activated protein C:F2R [plasma membrane] (Rattus norvegicus)
PROCR:Activated protein C [plasma membrane] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Rattus norvegicus)
PROCR:Activated protein C [plasma membrane] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Factor Xa inhibitors binds Xa (Rattus norvegicus)
factor Xa:Factor Xa inhibitors [plasma membrane] (Rattus norvegicus)
factor Xa [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PROCR binds Protein C (Rattus norvegicus)
PROCR(18-?):Activated protein C [extracellular region] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
SERPINA5 binds activated protein C (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
SERPINA5:Activated protein C [extracellular region] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Soluble PROCR binds activated protein C (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PROCR(18-?):Activated protein C [extracellular region] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Rattus norvegicus)
Extracellular thrombin inactivating complexes [extracellular region] (Rattus norvegicus)
SERPINA5:Activated protein C [extracellular region] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Rattus norvegicus)
Ca2+ [extracellular region]
factor XIIIa [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Rattus norvegicus)
factor XIIIa [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Rattus norvegicus)
Extracellular thrombin inactivating complexes [extracellular region] (Rattus norvegicus)
SERPINA5:Activated protein C [extracellular region] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
factor Xa:Factor Xa inhibitors [plasma membrane] (Rattus norvegicus)
factor Xa [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Rattus norvegicus)
thrombin:cleaved SERPINC1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Extrinsic Pathway of Fibrin Clot Formation (Rattus norvegicus)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Rattus norvegicus)
factor Xa [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Rattus norvegicus)
Ca2+ [extracellular region]
factor VII -> factor VIIa (Rattus norvegicus)
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Rattus norvegicus)
factor Xa [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Rattus norvegicus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Rattus norvegicus)
Ca2+ [extracellular region]
factor VIIa [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Rattus norvegicus)
Ca2+ [extracellular region]
10xCbxE-F7(61-466):Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Intrinsic Pathway of Fibrin Clot Formation (Rattus norvegicus)
Factor IIa inhibitors (compounds) binds IIa (Rattus norvegicus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide) binds IIa (Rattus norvegicus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Rattus norvegicus)
Ca2+ [extracellular region]
factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Rattus norvegicus)
Ca2+ [extracellular region]
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Rattus norvegicus)
Ca2+ [extracellular region]
factor Xa [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Rattus norvegicus)
Extracellular thrombin inactivating complexes [extracellular region] (Rattus norvegicus)
SERPINA5:Activated protein C [extracellular region] (Rattus norvegicus)
Activated protein C [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
thrombin:cleaved SERPINC1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Factor IIa inhibitors:IIa [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Factor IIa inhibitors (peptide):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Thrombin binding to GP1b:IX:V (Rattus norvegicus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Rattus norvegicus)
Platelet degranulation (Rattus norvegicus)
Exocytosis of platelet dense granule content (Rattus norvegicus)
Platelet dense granule content [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Thrombin signalling through proteinase activated receptors (PARs) (Rattus norvegicus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Platelet homeostasis (Rattus norvegicus)
Platelet calcium homeostasis (Rattus norvegicus)
Elevation of cytosolic Ca2+ levels (Rattus norvegicus)
Cation influx mediated by TRPC3/6/7 (Rattus norvegicus)
Cations [extracellular region]
Ca2+ [extracellular region]
P2X1-mediated entry of Ca++ from plasma (Rattus norvegicus)
Ca2+ [extracellular region]
Reduction of cytosolic Ca++ levels (Rattus norvegicus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Rattus norvegicus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Rattus norvegicus)
Ca2+ [extracellular region]
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
TRPC1 translocates calcium from the extracellular region to the cytosol (Rattus norvegicus)
Ca2+ [extracellular region]
Innate Immune System (Rattus norvegicus)
Antimicrobial peptides (Rattus norvegicus)
INTL1 binds bacterial glycans (Rattus norvegicus)
INTL1:bacterial glycan [extracellular region] (Rattus norvegicus)
ITLN1 trimer:Ca2+ [extracellular region] (Rattus norvegicus)
ITLNY1:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
ITLN1 trimer:Ca2+ [extracellular region] (Rattus norvegicus)
ITLNY1:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Metal sequestration by antimicrobial proteins (Rattus norvegicus)
S100A8:S100A9 binds Mn2+ (Rattus norvegicus)
S100A8:S100A9:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Rattus norvegicus)
S100A8:S100A9:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
S100A8:S100A9 binds Zn2+ (Rattus norvegicus)
S100A8:S100A9:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2A binds bacterial phospholipids (Rattus norvegicus)
PLA2G2A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2A:phospholipids [extracellular region] (Rattus norvegicus)
PLA2G2A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Complement cascade (Rattus norvegicus)
Initial triggering of complement (Rattus norvegicus)
Conversion of C2 into C2a and C2b (Rattus norvegicus)
C4 activators [plasma membrane] (Rattus norvegicus)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Rattus norvegicus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
Conversion of C4 into C4a and C4b (Rattus norvegicus)
C4 activators [plasma membrane] (Rattus norvegicus)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Rattus norvegicus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
Creation of C4 and C2 activators (Rattus norvegicus)
Classical antibody-mediated complement activation (Rattus norvegicus)
Activation of C1r (Rattus norvegicus)
C-reactive protein pentamer:phosphocholine:C1Q [extracellular region] (Rattus norvegicus)
C-reactive protein pentamer:phosphocholine [plasma membrane] (Rattus norvegicus)
C-reactive protein homopentamer [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Lectin pathway of complement activation (Rattus norvegicus)
Activation of MASPs (Rattus norvegicus)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Rattus norvegicus)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Rattus norvegicus)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
CL-LK binds carbohydrates on target cell surface (Rattus norvegicus)
Ca2+ [extracellular region]
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
Ficolins bind to repetitive carbohydrate structures on the target cell surface (Rattus norvegicus)
Ficolin-1 binds to molecular patterns on the target cell surface (Rattus norvegicus)
Ca2+ [extracellular region]
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
Ficolin-2 binds to molecular patterns on the target cell surface (Rattus norvegicus)
Ca2+ [extracellular region]
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Rattus norvegicus)
Ca2+ [extracellular region]
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
Regulation of Complement cascade (Rattus norvegicus)
Thrombin, ELANE cleave C5 (Rattus norvegicus)
Activated thrombin, (ELANE) [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Toll-like Receptor Cascades (Rattus norvegicus)
Regulation of TLR by endogenous ligand (Rattus norvegicus)
S100A1 binds TLR4:LY96 (Rattus norvegicus)
S100A1 dimer:Ca(2+) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
S100A1:TLR4:LY96 [plasma membrane] (Rattus norvegicus)
S100A1 dimer:Ca(2+) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Metabolism (Rattus norvegicus)
Integration of energy metabolism (Rattus norvegicus)
Regulation of insulin secretion (Rattus norvegicus)
Calcium Influx through Voltage-gated Calcium Channels (Rattus norvegicus)
Ca2+ [extracellular region]
Metabolism of lipids (Rattus norvegicus)
Fatty acid metabolism (Rattus norvegicus)
Arachidonate metabolism (Rattus norvegicus)
Synthesis of 5-eicosatetraenoic acids (Rattus norvegicus)
PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Rattus norvegicus)
PON1,2,3:2xCa2+ dimers [extracellular region] (Rattus norvegicus)
PON1:2xCa2+ dimer [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PON2:2xCa2+ dimer [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PON3:2xCa2+ dimer [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Phospholipid metabolism (Rattus norvegicus)
Glycerophospholipid biosynthesis (Rattus norvegicus)
Acyl chain remodelling of PC (Rattus norvegicus)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Rattus norvegicus)
PLA2(16) [extracellular region] (Rattus norvegicus)
PLA2G10:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Acyl chain remodelling of PE (Rattus norvegicus)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Rattus norvegicus)
PLA2(16) [extracellular region] (Rattus norvegicus)
PLA2G10:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Acyl chain remodelling of PG (Rattus norvegicus)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Rattus norvegicus)
PLA2(16) [extracellular region] (Rattus norvegicus)
PLA2G10:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G3:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Acyl chain remodelling of PI (Rattus norvegicus)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Rattus norvegicus)
PLA2(15) [extracellular region] (Rattus norvegicus)
PLA2G10:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Acyl chain remodelling of PS (Rattus norvegicus)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Rattus norvegicus)
PLA2(15) [extracellular region] (Rattus norvegicus)
PLA2G10:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Synthesis of PA (Rattus norvegicus)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Rattus norvegicus)
PLA2(15) [extracellular region] (Rattus norvegicus)
PLA2G10:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G12A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G1B:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2A:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2D:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G2F:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
PLA2G5:Ca2+ [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Metabolism of nucleotides (Rattus norvegicus)
Nucleotide catabolism (Rattus norvegicus)
Phosphate bond hydrolysis by NTPDase proteins (Rattus norvegicus)
NTPDase1 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Ca2+ [extracellular region]
Metabolism of proteins (Rattus norvegicus)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Rattus norvegicus)
Thrombin proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Muscle contraction (Rattus norvegicus)
Cardiac conduction (Rattus norvegicus)
Ion homeostasis (Rattus norvegicus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Rattus norvegicus)
Ca2+ [extracellular region]
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Rattus norvegicus)
Ca2+ [extracellular region]
TRPC1 translocates calcium from the extracellular region to the cytosol (Rattus norvegicus)
Ca2+ [extracellular region]
Phase 0 - rapid depolarisation (Rattus norvegicus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)
Ca2+ [extracellular region]
Phase 2 - plateau phase (Rattus norvegicus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)
Ca2+ [extracellular region]
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
Acetylcholine binding and downstream events (Rattus norvegicus)
Postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)
Ca2+ [extracellular region]
Presynaptic nicotinic acetylcholine receptors (Rattus norvegicus)
Highly calcium permeable nicotinic acetylcholine receptors (Rattus norvegicus)
Activation of highly calcium permeable nicotinic acetylcholine receptors (Rattus norvegicus)
Ca2+ [extracellular region]
Activation of NMDA receptors and postsynaptic events (Rattus norvegicus)
Unblocking of NMDA receptors, glutamate binding and activation (Rattus norvegicus)
Ca2+ influx into the post-synaptic cell (Rattus norvegicus)
Ca2+ [extracellular region]
Activation of kainate receptors upon glutamate binding (Rattus norvegicus)
Ionotropic activity of kainate receptors (Rattus norvegicus)
Activation of Ca-permeable Kainate Receptor (Rattus norvegicus)
Activation of Ca-permeable Kainate receptors (Rattus norvegicus)
Ca2+ [extracellular region]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Rattus norvegicus)
Activation of AMPA receptors (Rattus norvegicus)
Activation of Ca permeable AMPA receptors (Rattus norvegicus)
Ca2+ [extracellular region]
HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Rattus norvegicus)
Ca2+ [extracellular region]
HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Rattus norvegicus)
Ca2+ [extracellular region]
Presynaptic depolarization and calcium channel opening (Rattus norvegicus)
Ca2+ influx through voltage gated Ca2+ channels (Rattus norvegicus)
Ca2+ [extracellular region]
Reproduction (Rattus norvegicus)
Fertilization (Rattus norvegicus)
Sperm Motility And Taxes (Rattus norvegicus)
CatSper Channel Mediated Calcium Transport (Rattus norvegicus)
Ca2+ [extracellular region]
Sensory Perception (Rattus norvegicus)
Visual phototransduction (Rattus norvegicus)
The phototransduction cascade (Rattus norvegicus)
Activation of the phototransduction cascade (Rattus norvegicus)
cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Rattus norvegicus)
Ca2+ [extracellular region]
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Autophosphorylation of SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Release of CSK from SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK activation by SRC (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dissociation of RAS:RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Ca2+ [extracellular region]
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
CASR:Ca2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
CASR:Ca2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
G alpha (q) signalling events (Rattus norvegicus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
CASR:Ca2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Rattus norvegicus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
CASR:Ca2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Rattus norvegicus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Thrombin:Proteinase-activated receptors [plasma membrane] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
GPCR ligand binding (Rattus norvegicus)
Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
Peptide ligand-binding receptors (Rattus norvegicus)
Proteinase-activated receptors can bind thrombin (Rattus norvegicus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Ca2+ [extracellular region]
Class C/3 (Metabotropic glutamate/pheromone receptors) (Rattus norvegicus)
CASR binds Ca2+ (Rattus norvegicus)
Ca2+ [extracellular region]
CASR:Ca2+ [plasma membrane] (Rattus norvegicus)
Ca2+ [extracellular region]
GPRC6A can bind L-alpha amino acids and calcium (Rattus norvegicus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Rattus norvegicus)
GPRC6A ligands [extracellular region]
Ca2+ [extracellular region]
Transport of small molecules (Rattus norvegicus)
Ion channel transport (Rattus norvegicus)
Ion transport by P-type ATPases (Rattus norvegicus)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Rattus norvegicus)
Ca2+ [extracellular region]
Stimuli-sensing channels (Rattus norvegicus)