Factors VIIIa and IXa associate on cell surfaces to form a complex that very efficiently catalyzes the activation of factor X, the so-called "intrinsic tenase complex". In vitro, negatively charged phospholipids can provide an appropriate surface. In the body, the surface is provided by the plasma membranes of activated platelets (Gilbert and Arena 1996).
Gilbert, GE, Arena, AA
© 2023 Reactome
