TRPV4 tetramer transports calcium ions (Ca2+) from the extracellular region to the cytosol

Stable Identifier
R-BTA-9858823
Type
Reaction [transition]
Species
Bos taurus
Compartment
extracellular region, plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TRPV4 tetramer transports calcium ions (Ca2+) from the extracellular region to the cytosol
Mechanical stretching of capillary endothelial cells causes opening of TRPV4 channels and influx of calcium ions from the extracellular region to the cytosol (Thodeti et al. 2009).
Literature References
PubMed ID Title Journal Year
19359599 TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling

Thodeti, CK, Matthews, B, Ravi, A, Mammoto, A, Ghosh, K, Bracha, AL, Ingber, DE

Circ Res 2009
Participants
Input
Output
Catalyst Activity

calcium channel activity of TRPV4 tetramer [plasma membrane]

Physical Entity
TRPV4 tetramer [plasma membrane] (Bos taurus)
Activity
calcium channel activity (GO:0005262)
Orthologous Events
TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol (Homo sapiens)
Authored
May, B  (2024-01-14)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-01-14)
Cite Us!