P2rx7 trimer translocates cations from the extracellular region to the cytosol

Stable Identifier
R-RNO-9907601
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
General
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P2rx7 trimer translocates cations from the extracellular region to the cytosol
The P2rx7 trimer is an ATP-gated cation channel that passively transports calcium and sodium ions (Ca2+ and Na+) along the concentration gradient from the extracellular region to the cytosol (Surprenant et al. 1999, Egan and Khakh 2004).
Literature References
PubMed ID Title Journal Year
8614837 The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

Surprenant, A, Rassendren, F, Kawashima, E, North, RA, Buell, G

Science 1996
15056721 Contribution of calcium ions to P2X channel responses

Egan, TM, Khakh, BS

J Neurosci 2004
Participants
Input
Output
Catalyst Activity

extracellularly ATP-gated monoatomic cation channel activity of ATP:p2x7 oligomer [plasma membrane]

Physical Entity
ATP:p2x7 oligomer [plasma membrane] (Rattus norvegicus)
Activity
extracellularly ATP-gated monoatomic cation channel activity (GO:0004931)
Orthologous Events
P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol (Homo sapiens)
Authored
May, B  (2024-04-10)
Reviewed
Farach-Carson, MC  (2024-10-27)
Wu, D  (2024-10-27)
Created
May, B  (2024-04-13)
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