Ficolin-3 binds to molecular patterns on the target cell surface

Stable Identifier
Reaction [binding]
Homo sapiens
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Ficolin-3 (H-ficolin, FCN3, Hakata antigen) consists of a collagen-like strand and three C-terminal recognition domains, which bind to carbohydrates on the target surface. Circulating FCN3 is associated with mannan-binding lectin-associated serine proteases (MASP). Upon ligand binding the FCN3:MASP complex triggers activation of the lectin pathway (Matsushita et al. 2002, Teillet et al. 2008, Zacho et al. 2012). FCN3 can specifically recognize Aerococcus viridans (Tsujimura et al. 2002, Zacho et al. 2012) and binds patterns of bacterial polysaccharides such as d-fucose and galactose (Garlatti et al. 2007). In adition to pathogenic ligands, FCN3 was reported to bind apoptotic Jurkat cells (Kuraya et al. 2005).
Literature References
PubMed ID Title Journal Year
15804047 Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation

Liu, X, Matsushita, M, Kuraya, M, Ming, Z, Fujita, T

Immunobiology 2005
18596036 Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins

Martin, L, Teillet, F, Arlaud, GJ, Lacroix, M, Gaboriaud, C, Thielens, NM

J Biol Chem 2008
20375619 Structural insights into the recognition properties of human ficolins

Martin, L, Thielens, NM, Garlatti, V, Lacroix, M, Gaboriaud, C, Arlaud, GJ, Gout, E

J Innate Immun 2010
22238349 Studies of the pattern recognition molecule H-ficolin: specificity and purification

Terp, R, Jensen, L, Jensenius, JC, Thiel, S, Zacho, RM

J. Biol. Chem. 2012
11907111 Activation of the lectin complement pathway by H-ficolin (Hakata antigen)

Kuraya, M, Matsushita, M, Tsujimura, M, Hamasaki, N, Shiraki, H, Fujita, T

J. Immunol. 2002
17215869 Structural insights into the innate immune recognition specificities of L- and H-ficolins

Endo, Y, Martin, L, Fontecilla-Camps, JC, Matsushita, M, Thielens, NM, Garlatti, V, Lacroix, M, Gaboriaud, C, Belloy, N, Arlaud, GJ, Fujita, T

EMBO J. 2007
12367778 Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth

Sagara, Y, Kojima, E, Miyazaki, T, Tsujimura, M, Okochi, K, Maeda, Y, Shiraki, H

Clin. Chim. Acta 2002
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