Cacna1d:Cacna2d2:Cacnb2 (Cav1.3 channel) transports calcium into the cytosol of an inner hair cell

Stable Identifier
R-MMU-9659489
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cacna1d:Cacna2d2:Cacnb2 (Cav1.3 channel) transports calcium into the cytosol of an inner hair cell
Voltage-gated L-type Cav1.3 calcium channels comprising Cacna1d:Cacna2d2:Cacnb2 open in response to depolarization of the inner hair cell caused by an influx of cations (calcium and potassium) through mechanoelectrical transduction (MET) channels in the apical stereocilia (Nemzou et al. 2006, Neef et al. 2009, Fell et al. 2016, Vincent et al. 2017). The calcium channels are located on the basolateral surface of the inner hair cells in close proximity to cytoplasmic ribbon structures that temporarily anchor and cluster glutamate vesicles near the inner face of the plasma membrane (Brandt et al. 2005, Nemzou et al. 2006). The proximity between the Cav1.3 calcium channels and the ribbon structures allows a small number (about 10) of calcium channels to produce high localized concentrations of Ca2+ near the site of glutamate release (Brandt et al. 2005, Frank et al. 2009, Vincent et al. 2014).
Literature References
PubMed ID Title Journal Year
16354915 Few CaV1.3 channels regulate the exocytosis of a synaptic vesicle at the hair cell ribbon synapse

Brandt, A, Khimich, D, Moser, T

J. Neurosci. 2005
27798183 α2δ2 Controls the Function and Trans-Synaptic Coupling of Cav1.3 Channels in Mouse Inner Hair Cells and Is Essential for Normal Hearing

Fell, B, Eckrich, S, Blum, K, Eckrich, T, Hecker, D, Obermair, GJ, Münkner, S, Flockerzi, V, Schick, B, Engel, J

J. Neurosci. 2016
25122888 Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels

Vincent, PF, Bouleau, Y, Safieddine, S, Petit, C, Dulon, D

J. Neurosci. 2014
19246382 Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells

Frank, T, Khimich, D, Neef, A, Moser, T

Proc. Natl. Acad. Sci. U.S.A. 2009
16828974 Synaptic organization in cochlear inner hair cells deficient for the CaV1.3 (alpha1D) subunit of L-type Ca2+ channels

Nemzou N, RM, Bulankina, AV, Khimich, D, Giese, A, Moser, T

Neuroscience 2006
19710324 The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing

Neef, J, Gehrt, A, Bulankina, AV, Meyer, AC, Riedel, D, Gregg, RG, Strenzke, N, Moser, T

J. Neurosci. 2009
28193694 Different CaV1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells

Vincent, PF, Bouleau, Y, Charpentier, G, Emptoz, A, Safieddine, S, Petit, C, Dulon, D

J. Neurosci. 2017
Participants
Input
Output
Catalyst Activity

voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels of Cacna1d:Cacnb2:Cacna2d2 [plasma membrane]

Physical Entity
Cacna1d:Cacnb2:Cacna2d2 [plasma membrane] (Mus musculus)
Activity
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels (GO:0099635)
This event is regulated
Positively by
Regulator
K+ [cytosol]
Orthologous Events
CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell (Homo sapiens)
Authored
May, B  (2019-08-27)
Reviewed
Furness, DN  (2020-09-14)
Created
May, B  (2019-08-27)
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