P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol

Stable Identifier
R-HSA-9905964
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
ReviewStatus
5/5
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P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol
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ATP activates the P2RX7 (P2X7, P2Z) trimer to passively transport cations, notably calcium (Wiley et al. 1993, Humphreys et al. 1998, Wiley et al. 1998, Riedel et al. 2007, and inferred from the rat homologue, reviewed in Volonté et al. 2012, Di Virgilio et al. 2018). Calcium and sodium ions follow their concentration gradients from the extracellular region to the cytosol. In mouse osteocytes, P2rx7 is located at the plasma membrane in a complex with the Pannexin1 (Panx1) anion channel (Seref-Ferlengez et al. 2016).
Literature References
PubMed ID Title Journal Year
9658186 Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues

Humphreys, BD, Virginio, C, Surprenant, A, Rice, J, Dubyak, GR

Mol Pharmacol 1998
9814970 Partial agonists and antagonists reveal a second permeability state of human lymphocyte P2Z/P2X7 channel

Wiley, JS, Gargett, CE, Zhang, W, Snook, MB, Jamieson, GP

Am J Physiol 1998
9038151 The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

Rassendren, F, Buell, GN, Virginio, C, Collo, G, North, RA, Surprenant, A

J Biol Chem 1997
7688203 The ATP4- receptor-operated channel (P2Z class) of human lymphocytes allows Ba2+ and ethidium+ uptake: inhibition of fluxes by suramin

Wiley, JS, Chen, R, Jamieson, GP

Arch Biochem Biophys 1993
17483156 Influence of extracellular monovalent cations on pore and gating properties of P2X7 receptor-operated single-channel currents

Riedel, T, Schmalzing, G, Markwardt, F

Biophys J 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

extracellularly ATP-gated monoatomic cation channel activity of ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane]

Physical Entity
ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane] (Homo sapiens)
Activity
extracellularly ATP-gated monoatomic cation channel activity (GO:0004931)
Inferred From
P2rx7 trimer translocates cations from the extracellular region to the cytosol (Rattus norvegicus)
P2rx7 in ATP:P2rx7:Panx1 transports cations from the extracellular region to the cytosol (Mus musculus)
Cross References
RHEA
Authored
May, B  (2024-03-28)
Reviewed
Farach-Carson, MC  (2024-10-27)
Wu, D  (2024-10-27)
Created
May, B  (2024-03-29)
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