Reactome | Activation of highly calcium permeable nicotinic acetylcholine receptors

Activation of highly calcium permeable nicotinic acetylcholine receptors

Stable Identifier

R-HSA-622326

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
        
        Activation of highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)

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Activation of highly calcium permeable nicotinic acetylcholine receptors

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Nicotinic acetylcholine receptors are activated upon ligand binding which opens the acetylcholine channels and permits Ca2+ and Na+ ion influx depending on the subunit composition and stoichiometry of the subunits. The ratio of Ca2+ to Na+ ion influx varies making the receptors either highly Na+ permeable or Ca2+ permeable.

Literature References

PubMed ID	Title	Journal	Year
10945867	Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine Grottick, AJ, Trube, G, Corrigall, WA, Huwyler, J, Malherbe, P, Wyler, R, Higgins, GA	J Pharmacol Exp Ther	2000
12810063	Fractional Ca(2+) current through human neuronal alpha7 nicotinic acetylcholine receptors Fucile, S, Renzi, M, Lax, P, Eusebi, F	Cell Calcium	2003