factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)

Stable Identifier
R-HSA-158164
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
activation of factor X by VIIIa:IXa
ReviewStatus
5/5
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factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)
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Factor IXa, in a complex with factor VIIIa on the surfaces of activated platelets (the "intrinsic tenase complex"), catalyzes the formation of activated factor X with high efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)
Literature References
PubMed ID Title Journal Year
2110473 Kinetics of coagulation factor X activation by platelet-bound factor IXa

Ahmad, SS, Ashby, B, Walsh, PN, Rawala-Sheikh, R

Biochemistry 1990
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of factor VIIIa:factor IXa [plasma membrane]

Physical Entity
factor VIIIa:factor IXa [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
This event is regulated
Negatively by
Regulator
FVIIIa:FIXa:PROS1 [plasma membrane] (Homo sapiens)
Active Unit
11xCbxE-PROS1 [extracellular region]
Orthologous Events
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Bos taurus)
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Gallus gallus)
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Mus musculus)
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Rattus norvegicus)
Authored
D'Eustachio, P  (2005-01-20)
Created
D'Eustachio, P  (2005-01-20)
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