factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)

Stable Identifier
R-HSA-158164
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
activation of factor X by VIIIa:IXa
Locations in the PathwayBrowser
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Factor IXa, in a complex with factor VIIIa on the surfaces of activated platelets (the "intrinsic tenase complex"), catalyzes the formation of activated factor X with high efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)

Literature References
PubMed ID Title Journal Year
2110473 Kinetics of coagulation factor X activation by platelet-bound factor IXa

Rawala-Sheikh, R, Ahmad, SS, Ashby, B, Walsh, PN

Biochemistry 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of factor VIIIa:factor IXa [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created