CDH11 forms heterotypic trans dimer with CDH8

Stable Identifier
R-HSA-9833672
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CDH11 forms heterotypic trans dimer with CDH8
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on surface plasmon resonance (SPR) experiments using mouse recombinant proteins, CDH11 forms heterotypic trans dimers with CDH8 (Brasch et al. 2018). This finding is supported by the mixed cell-aggregation assay in which mouse L-fibroblasts expressing recombinant human CDH11 were shown to aggregate with mouse L-fibroblasts expressing recombinant human CDH8 (Shimoyama et al. 2000).
Literature References
PubMed ID Title Journal Year
10861224 Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins

Tsujimoto, G, Shimoyama, Y, Natori, M, Kitajima, M

Biochem J 2000
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Inferred From
Cdh11 forms heterotypic trans dimer with Cdh8 (Mus musculus)
Authored
Orlic-Milacic, M  (2023-05-02)
Reviewed
Brasch, J  (2023-05-16)
Created
Orlic-Milacic, M  (2023-05-02)
Cite Us!