Reactome | HTR3A pentamer:5HT transports Na+,K+,Ca2+

HTR3A pentamer:5HT transports Na+,K+,Ca2+

Stable Identifier

R-HSA-9648983

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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HTR3A pentamer:5HT transports Na+,K+,Ca2+

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The 5-hydroxytryptamine receptor (HTR3) family are members of the superfamily of ligand-gated ion channels (LGICs). Five receptors (HTR3A-E) can form a homopentamer (HTR3A) or heteropentamers (HTR3A with B, C, D or E) (Barrera et al. 2005, Niesler et al. 2007; reviews - Barnes et al. 2009, Wu et al. 2015). Binding of the neurotransmitter 5-hydroxytryptamine (5HT, serotonin) to the HTR3 pentamer opens the channel making it permeable to sodium, potassium, and calcium ions, which in turn leads to an excitatory response in neurons (Miyake et al. 1995, Davies et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9950429	The 5-HT3B subunit is a major determinant of serotonin-receptor function Davies, PA, Pistis, M, Hanna, MC, Peters, JA, Lambert, JJ, Hales, TG, Kirkness, EF	Nature	1999
26238288	Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery Wu, ZS, Cheng, H, Jiang, Y, Melcher, K, Xu, HE	Acta Pharmacol. Sin.	2015
17392525	Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E Niesler, B, Walstab, J, Combrink, S, Moller, D, Kapeller, J, Rietdorf, J, Bonisch, H, Gothert, M, Rappold, G, Bruss, M	Mol Pharmacol	2007
18761359	The 5-HT3 receptor--the relationship between structure and function Barnes, NM, Hales, TG, Lummis, SC, Peters, JA	Neuropharmacology	2009
16116092	Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors Barrera, NP, Herbert, P, Henderson, RM, Martin, IL, Edwardson, JM	Proc. Natl. Acad. Sci. U.S.A.	2005
7565620	Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species Miyake, A, Mochizuki, S, Takemoto, Y, Akuzawa, S	Mol Pharmacol	1995