HTR3A pentamer:5HT transports Na+,K+,Ca2+

Stable Identifier
R-HSA-9648983
Type
Reaction
Species
Homo sapiens
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The 5-hydroxytryptamine receptor (HTR3) family are members of the superfamily of ligand-gated ion channels (LGICs). Five receptors (HTR3A-E) can form a homopentamer (HTR3A) or heteropentamers (HTR3A with B, C, D or E) (Barrera et al. 2005, Niesler et al. 2007; reviews - Barnes et al. 2009, Wu et al. 2015). Binding of the neurotransmitter 5-hydroxytryptamine (5HT, serotonin) to the HTR3 pentamer opens the channel making it permeable to sodium, potassium, and calcium ions, which in turn leads to an excitatory response in neurons (Miyake et al. 1995, Davies et al. 1999).

Literature References
PubMed ID Title Journal Year
9950429 The 5-HT3B subunit is a major determinant of serotonin-receptor function

Kirkness, EF, Peters, JA, Davies, PA, Pistis, M, Hales, TG, Lambert, JJ, Hanna, MC

Nature 1999
26238288 Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery

Jiang, Y, Cheng, H, Wu, ZS, Melcher, K, Xu, HE

Acta Pharmacol. Sin. 2015
17392525 Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E

Moller, D, Walstab, J, Rietdorf, J, Kapeller, J, Niesler, B, Combrink, S, Rappold, G, Gothert, M, Bonisch, H, Bruss, M

Mol Pharmacol 2007
18761359 The 5-HT3 receptor--the relationship between structure and function

Peters, JA, Barnes, NM, Lummis, SC, Hales, TG

Neuropharmacology 2009
16116092 Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors

Henderson, RM, Herbert, P, Martin, IL, Edwardson, JM, Barrera, NP

Proc. Natl. Acad. Sci. U.S.A. 2005
7565620 Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species

Miyake, A, Akuzawa, S, Takemoto, Y, Mochizuki, S

Mol Pharmacol 1995
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Catalyst Activity

serotonin-gated cation-selective channel activity of HTR3A pentamer:5HT [plasma membrane]

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